Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
Identifieur interne : 002E67 ( Main/Exploration ); précédent : 002E66; suivant : 002E68Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
Auteurs : Ken Nakamura [États-Unis] ; Chadwick W. Christine [États-Unis] ; Philip A. Starr [États-Unis] ; William J. Marks Jr. [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents (administration & dosage), Combined Modality Therapy, Deep Brain Stimulation, Deep brain stimulation, Dominance, Cerebral (physiology), Female, Humans, Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Nervous system diseases, Neurologic Examination (drug effects), Parkinson disease, Parkinson's disease, Prognosis, Prospective Studies, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Reaction Time (drug effects), Reaction Time (physiology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, Treatment Outcome, deep brain stimulation, globus pallidus, subthalamic nucleus.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- drug effects : Motor Skills, Neurologic Examination, Psychomotor Performance, Reaction Time, Subthalamic Nucleus.
- physiology : Dominance, Cerebral, Motor Skills, Psychomotor Performance, Reaction Time.
- physiopathology : Subthalamic Nucleus.
- Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21300
Affiliations:
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Le document en format XML
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Starr</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Research, Education Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Marks Jr, William J" sort="Marks Jr, William J" uniqKey="Marks Jr W" first="William J." last="Marks Jr.">William J. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="619">619</biblScope><biblScope unit="page" to="626">626</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D5C245E4CA6BCBF43155D8245133C39974569F22</idno><idno type="DOI">10.1002/mds.21300</idno><idno type="ArticleID">MDS21300</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (administration & dosage)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Deep brain stimulation</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Motor Skills (physiology)</term><term>Nervous system diseases</term><term>Neurologic Examination (drug effects)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prognosis</term><term>Prospective Studies</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic nucleus</term><term>Treatment Outcome</term><term>deep brain stimulation</term><term>globus pallidus</term><term>subthalamic nucleus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Skills</term><term>Neurologic Examination</term><term>Psychomotor Performance</term><term>Reaction Time</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Motor Skills</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Noyau sousthalamique</term><term>Parkinson maladie</term><term>Stimulation cérébrale profonde</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name></region><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W." last="Christine">Chadwick W. Christine</name><name sortKey="Marks Jr, William J" sort="Marks Jr, William J" uniqKey="Marks Jr W" first="William J." last="Marks Jr.">William J. Marks Jr.</name><name sortKey="Marks Jr, William J" sort="Marks Jr, William J" uniqKey="Marks Jr W" first="William J." last="Marks Jr.">William J. Marks Jr.</name><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A." last="Starr">Philip A. Starr</name><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A." last="Starr">Philip A. Starr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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