Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
Identifieur interne : 000B43 ( Istex/Corpus ); précédent : 000B42; suivant : 000B44Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
Auteurs : Ken Nakamura ; Chadwick W. Christine ; Philip A. Starr ; William J. Marks Jr.Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
English descriptors
Abstract
Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21300
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ISTEX:D5C245E4CA6BCBF43155D8245133C39974569F22Le document en format XML
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The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ken Nakamura MD, PhD</name><affiliations><json:string>Department of Neurology, University of California, San Francisco, California, USA</json:string><json:string>Parkinson's Disease Research, Education Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA</json:string></affiliations></json:item><json:item><name>Chadwick W. Christine MD</name><affiliations><json:string>Department of Neurology, University of California, San Francisco, California, USA</json:string></affiliations></json:item><json:item><name>Philip A. 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Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>Parkinson's disease</term></item><item><term>subthalamic nucleus</term></item><item><term>globus pallidus</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-08-28">Received</change><change when="2006-09-14">Registration</change><change when="2007-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D5C245E4CA6BCBF43155D8245133C39974569F22/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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The CME form can be found on page 755 and is available online at <url href="http://www.movementdisorders.org/education/activities.html"> http://www.movementdisorders.org/education/activities.html </url> . </p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the <i>off</i> medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DBS and Fine Motor Function</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Ken</namePart><namePart type="family">Nakamura</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University of California, San Francisco, California, USA</affiliation><affiliation>Parkinson's Disease Research, Education Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA</affiliation><description>Correspondence: Center for Parkinson's Disease and Movement Disorders, San Francisco VA Medical Center (127P), 4150 Clement Street, San Francisco, CA 94121</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chadwick W.</namePart><namePart type="family">Christine</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of California, San Francisco, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philip A.</namePart><namePart type="family">Starr</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Parkinson's Disease Research, Education Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA</affiliation><affiliation>Department of Neurological Surgery, University of California, San Francisco, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William J.</namePart><namePart type="family">Marks Jr.</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of California, San Francisco, California, USA</affiliation><affiliation>Parkinson's Disease Research, Education Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-04-15</dateIssued><dateCaptured encoding="w3cdtf">2005-08-28</dateCaptured><dateValid encoding="w3cdtf">2006-09-14</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">25</extent><extent unit="words">5507</extent></physicalDescription><abstract lang="en">Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>Parkinson's disease</topic><topic>subthalamic nucleus</topic><topic>globus pallidus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> This article is part of the journal's CME program. The CME form can be found on page 755 and is available online at http://www.movementdisorders.org/education/activities.html .</note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>619</start><end>626</end><total>8</total></extent></part></relatedItem><identifier type="istex">D5C245E4CA6BCBF43155D8245133C39974569F22</identifier><identifier type="DOI">10.1002/mds.21300</identifier><identifier type="ArticleID">MDS21300</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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