Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.
Identifieur interne : 001A53 ( Ncbi/Curation ); précédent : 001A52; suivant : 001A54Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.
Auteurs : Ken Nakamura [États-Unis] ; Chadwick W. Christine ; Philip A. Starr ; William J. MarksSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents (administration & dosage), Combined Modality Therapy, Deep Brain Stimulation, Dominance, Cerebral (physiology), Female, Humans, Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Neurologic Examination (drug effects), Prognosis, Prospective Studies, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Reaction Time (drug effects), Reaction Time (physiology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- drug effects : Motor Skills, Neurologic Examination, Psychomotor Performance, Reaction Time, Subthalamic Nucleus.
- physiology : Dominance, Cerebral, Motor Skills, Psychomotor Performance, Reaction Time.
- physiopathology : Subthalamic Nucleus.
- Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short-term follow-up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks.
DOI: 10.1002/mds.21300
PubMed: 17230483
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pubmed:17230483Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.</title><author><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of California, San Francisco, CA, USA. ken.nakamura@ucsf.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name></author><author><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A" last="Starr">Philip A. Starr</name></author><author><name sortKey="Marks, William J" sort="Marks, William J" uniqKey="Marks W" first="William J" last="Marks">William J. Marks</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21300</idno><idno type="RBID">pubmed:17230483</idno><idno type="pmid">17230483</idno><idno type="wicri:Area/PubMed/Corpus">002886</idno><idno type="wicri:Area/PubMed/Curation">002886</idno><idno type="wicri:Area/PubMed/Checkpoint">002839</idno><idno type="wicri:Area/Ncbi/Merge">001A53</idno><idno type="wicri:Area/Ncbi/Curation">001A53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.</title><author><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of California, San Francisco, CA, USA. ken.nakamura@ucsf.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name></author><author><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A" last="Starr">Philip A. Starr</name></author><author><name sortKey="Marks, William J" sort="Marks, William J" uniqKey="Marks W" first="William J" last="Marks">William J. Marks</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (administration & dosage)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Motor Skills (physiology)</term><term>Neurologic Examination (drug effects)</term><term>Prognosis</term><term>Prospective Studies</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Skills</term><term>Neurologic Examination</term><term>Psychomotor Performance</term><term>Reaction Time</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Motor Skills</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short-term follow-up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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