Morphometric changes of sensorimotor structures in focal dystonia
Identifieur interne : 004172 ( Main/Merge ); précédent : 004171; suivant : 004173Morphometric changes of sensorimotor structures in focal dystonia
Auteurs : Mark Obermann [Allemagne] ; Ozguer Yaldizli [Allemagne] ; Armin De Greiff [Allemagne] ; Martin Lenard Lachenmayer [Allemagne] ; Anna Rebecca Buhl [Allemagne] ; Felicitus Tumczak [Allemagne] ; Elke Ruth Gizewski [Allemagne] ; Hans-Christoph Diener [Allemagne] ; Matthias Maschke [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BED) are the most common forms of local dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel-based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this study was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age- and gender-matched controls. High-resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001644
- to stream PascalFrancis, to step Curation: 001677
- to stream PascalFrancis, to step Checkpoint: 001582
Links to Exploration step
Pascal:07-0349115Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Morphometric changes of sensorimotor structures in focal dystonia</title><author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Lenard Lachenmayer, Martin" sort="Lenard Lachenmayer, Martin" uniqKey="Lenard Lachenmayer M" first="Martin" last="Lenard Lachenmayer">Martin Lenard Lachenmayer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier</s1><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bruederkrankenhaus Trier</wicri:noRegion><wicri:noRegion>Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0349115</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0349115 INIST</idno><idno type="RBID">Pascal:07-0349115</idno><idno type="wicri:Area/PascalFrancis/Corpus">001644</idno><idno type="wicri:Area/PascalFrancis/Curation">001677</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001582</idno><idno type="wicri:doubleKey">0885-3185:2007:Obermann M:morphometric:changes:of</idno><idno type="wicri:Area/Main/Merge">004172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Morphometric changes of sensorimotor structures in focal dystonia</title><author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Lenard Lachenmayer, Martin" sort="Lenard Lachenmayer, Martin" uniqKey="Lenard Lachenmayer M" first="Martin" last="Lenard Lachenmayer">Martin Lenard Lachenmayer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Duisburg<sub>¯</sub>Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier</s1><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bruederkrankenhaus Trier</wicri:noRegion><wicri:noRegion>Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Blepharospasm</term><term>Dystonia</term><term>Integration</term><term>Morphometry</term><term>Nervous system diseases</term><term>Torticollis</term><term>Voxel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Dystonie</term><term>Blépharospasme</term><term>Torticolis</term><term>Morphométrie</term><term>Voxel</term><term>Intégration</term><term>Noyau gris central</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BED) are the most common forms of local dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel-based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this study was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age- and gender-matched controls. High-resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name></noRegion><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name><name sortKey="Lenard Lachenmayer, Martin" sort="Lenard Lachenmayer, Martin" uniqKey="Lenard Lachenmayer M" first="Martin" last="Lenard Lachenmayer">Martin Lenard Lachenmayer</name><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004172 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004172 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:07-0349115
|texte= Morphometric changes of sensorimotor structures in focal dystonia
}}
| This area was generated with Dilib version V0.6.23. |  |