Morphometric changes of sensorimotor structures in focal dystonia.
Identifieur interne : 001B74 ( Ncbi/Checkpoint ); précédent : 001B73; suivant : 001B75Morphometric changes of sensorimotor structures in focal dystonia.
Auteurs : Mark Obermann [Allemagne] ; Ozguer Yaldizli ; Armin De Greiff ; Martin Lenard Lachenmayer ; Anna Rebecca Buhl ; Felicitus Tumczak ; Elke Ruth Gizewski ; Hans-Christoph Diener ; Matthias MaschkeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (pathology), Basal Ganglia (physiopathology), Blepharospasm (drug therapy), Blepharospasm (epidemiology), Blepharospasm (physiopathology), Botulinum Toxins, Type A (therapeutic use), Caudate Nucleus (pathology), Caudate Nucleus (physiopathology), Dystonic Disorders (drug therapy), Dystonic Disorders (epidemiology), Dystonic Disorders (physiopathology), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuromuscular Agents (therapeutic use), Psychomotor Disorders (drug therapy), Psychomotor Disorders (epidemiology), Severity of Illness Index, Torticollis (drug therapy), Torticollis (epidemiology), Torticollis (physiopathology).
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- epidemiology : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- pathology : Basal Ganglia, Caudate Nucleus.
- physiopathology : Basal Ganglia, Blepharospasm, Caudate Nucleus, Dystonic Disorders, Torticollis.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index.
Abstract
Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel-based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age- and gender-matched controls. High-resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin.
DOI: 10.1002/mds.21495
PubMed: 17443700
Affiliations:
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xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name></author><author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name></author><author><name sortKey="Lachenmayer, Martin Lenard" sort="Lachenmayer, Martin Lenard" uniqKey="Lachenmayer M" first="Martin Lenard" last="Lachenmayer">Martin Lenard Lachenmayer</name></author><author><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name></author><author><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name></author><author><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name></author><author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Basal Ganglia (pathology)</term><term>Basal Ganglia 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Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel-based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age- and gender-matched controls. High-resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name><name sortKey="Lachenmayer, Martin Lenard" sort="Lachenmayer, Martin Lenard" uniqKey="Lachenmayer M" first="Martin Lenard" last="Lachenmayer">Martin Lenard Lachenmayer</name><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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