Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging
Identifieur interne : 002C21 ( Main/Exploration ); précédent : 002C20; suivant : 002C22Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging
Auteurs : Thomas Eckert [États-Unis, Allemagne] ; Andrew Feigin [États-Unis] ; Daniel E. Lewis [États-Unis] ; Vijay Dhawan [États-Unis] ; Steven Frucht [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Brain (metabolism), Corpus Striatum (metabolism), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dihydroxyphenylalanine (pharmacokinetics), Dopamine (metabolism), Dopamine (physiology), Emission tomography, Female, Ganglia (metabolism), Ganglia (pathology), Human, Humans, Male, Metabolism, Middle Aged, Multiple System Atrophy (epidemiology), Multiple System Atrophy (metabolism), Nervous system diseases, Occipital Lobe (metabolism), PET, Parkinson Disease (epidemiology), Parkinson Disease (metabolism), Parkinson disease, Parkinson's disease, Positron, Positron emission tomography, Positron-Emission Tomography, Putamen (metabolism), Retrospective Studies, SWEDD, Spinocerebellar Degenerations (epidemiology), Spinocerebellar Degenerations (metabolism), Spinocerebellar Degenerations (pathology), Supranuclear Palsy, Progressive (epidemiology), Supranuclear Palsy, Progressive (metabolism), brain metabolism.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine.
- epidemiology : Multiple System Atrophy, Parkinson Disease, Spinocerebellar Degenerations, Supranuclear Palsy, Progressive.
- metabolism : Brain, Corpus Striatum, Dopamine, Ganglia, Multiple System Atrophy, Occipital Lobe, Parkinson Disease, Putamen, Spinocerebellar Degenerations, Supranuclear Palsy, Progressive.
- pathology : Ganglia, Spinocerebellar Degenerations.
- chemical , pharmacokinetics : Dihydroxyphenylalanine.
- chemical , physiology : Dopamine.
- Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Retrospective Studies.
Abstract
Dopaminergic imaging has been found to be normal in approximately 15% of parkinsonian patients enrolled in neuroprotective trials. We used 18F‐fluorodeoxyglucose positron emission tomography (FDG PET) to determine the metabolic basis for this finding. We reviewed scans from 185 patients with clinical signs of Parkinson's disease (PD) who underwent 18F‐fluorodopa PET imaging for diagnostic confirmation. Of this group, 27 patients (14.6%) had quantitatively normal scans; 8 of these patients were additionally scanned with FDG PET. Pattern analysis was performed on an individual scan basis to determine whether the metabolic changes were consistent with classic PD. Computer‐assisted single‐case assessments of the FDG PET scans of these 8 patients did not disclose patterns of regional metabolic change compatible with classical PD or an atypical parkinsonian variant. Similarly, network quantification revealed that PD‐related pattern expression was not elevated in these patients as it was in an age‐ and duration‐matched cohort with classical PD (P < 0.0001). None of these patients developed clinical signs of classical PD or of an atypical parkinsonian syndrome at a follow‐up visit conducted 3 years after imaging. The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21185
Affiliations:
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Le document en format XML
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<term>Dihydroxyphenylalanine (diagnostic use)</term>
<term>Dihydroxyphenylalanine (pharmacokinetics)</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine (physiology)</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Ganglia (metabolism)</term>
<term>Ganglia (pathology)</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Metabolism</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (epidemiology)</term>
<term>Multiple System Atrophy (metabolism)</term>
<term>Nervous system diseases</term>
<term>Occipital Lobe (metabolism)</term>
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<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<term>Positron emission tomography</term>
<term>Positron-Emission Tomography</term>
<term>Putamen (metabolism)</term>
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<term>Spinocerebellar Degenerations (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Dopaminergic imaging has been found to be normal in approximately 15% of parkinsonian patients enrolled in neuroprotective trials. We used 18F‐fluorodeoxyglucose positron emission tomography (FDG PET) to determine the metabolic basis for this finding. We reviewed scans from 185 patients with clinical signs of Parkinson's disease (PD) who underwent 18F‐fluorodopa PET imaging for diagnostic confirmation. Of this group, 27 patients (14.6%) had quantitatively normal scans; 8 of these patients were additionally scanned with FDG PET. Pattern analysis was performed on an individual scan basis to determine whether the metabolic changes were consistent with classic PD. Computer‐assisted single‐case assessments of the FDG PET scans of these 8 patients did not disclose patterns of regional metabolic change compatible with classical PD or an atypical parkinsonian variant. Similarly, network quantification revealed that PD‐related pattern expression was not elevated in these patients as it was in an age‐ and duration‐matched cohort with classical PD (P < 0.0001). None of these patients developed clinical signs of classical PD or of an atypical parkinsonian syndrome at a follow‐up visit conducted 3 years after imaging. The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome. © 2006 Movement Disorder Society</div>
</front>
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<name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
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<name sortKey="Lewis, Daniel E" sort="Lewis, Daniel E" uniqKey="Lewis D" first="Daniel E." last="Lewis">Daniel E. Lewis</name>
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<country name="Allemagne"><noRegion><name sortKey="Eckert, Thomas" sort="Eckert, Thomas" uniqKey="Eckert T" first="Thomas" last="Eckert">Thomas Eckert</name>
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