Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging
Identifieur interne : 004080 ( Main/Merge ); précédent : 004079; suivant : 004081Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging
Auteurs : Thomas Eckert [États-Unis, Allemagne] ; Andrew Feigin [États-Unis] ; Daniel E. Lewis [États-Unis] ; Vijay Dhawan [États-Unis] ; Steven Frucht [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
Dopaminergic imaging has been found to be normal in approximately 15% of parkinsonian patients enrolled in neuroprotective trials. We used 18F-fluorodeoxyglucose positron emission tomography (FDG PET) to determine the metabolic basis for this finding. We reviewed scans from 185 patients with clinical signs of Parkinson's disease (PD) who underwent 18F-fluorodopa PET imaging for diagnostic confirmation. Of this group, 27 patients (14.6%) had quantitatively normal scans; 8 of these patients were additionally scanned with FDG PET. Pattern analysis was performed on an individual scan basis to determine whether the metabolic changes were consistent with classic PD. Computer-assisted single-case assessments of the FDG PET scans of these 8 patients did not disclose patterns of regional metabolic change compatible with classical PD or an atypical parkinsonian variant. Similarly, network quantification revealed that PD-related pattern expression was not elevated in these patients as it was in an age- and duration-matched cohort with classical PD (P < 0.0001). None of these patients developed clinical signs of classical PD or of an atypical parkinsonian syndrome at a follow-up visit conducted 3 years after imaging. The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Regional metabolic changes in Parkinsonian patients with normal dopaminergic imaging</title><author><name sortKey="Eckert, Thomas" sort="Eckert, Thomas" uniqKey="Eckert T" first="Thomas" last="Eckert">Thomas Eckert</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology II, University of Magdeburg</s1><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Magdeburg</wicri:noRegion><wicri:noRegion>Department of Neurology II, University of Magdeburg</wicri:noRegion></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lewis, Daniel E" sort="Lewis, Daniel E" uniqKey="Lewis D" first="Daniel E." last="Lewis">Daniel E. 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York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology II, University of Magdeburg</s1><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Magdeburg</wicri:noRegion><wicri:noRegion>Department of Neurology II, University of Magdeburg</wicri:noRegion></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lewis, Daniel E" sort="Lewis, Daniel E" uniqKey="Lewis D" first="Daniel E." last="Lewis">Daniel E. Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Frucht, Steven" sort="Frucht, Steven" uniqKey="Frucht S" first="Steven" last="Frucht">Steven Frucht</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>The Neurological Institute, Columbia-Presbyterian Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System</s1><s2>Manhasset, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Human</term><term>Metabolism</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Homme</term><term>Métabolisme</term><term>Tomoscintigraphie</term><term>Positon</term><term>Tomographie émission positon</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopaminergic imaging has been found to be normal in approximately 15% of parkinsonian patients enrolled in neuroprotective trials. We used <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (FDG PET) to determine the metabolic basis for this finding. We reviewed scans from 185 patients with clinical signs of Parkinson's disease (PD) who underwent <sup>18</sup>F-fluorodopa PET imaging for diagnostic confirmation. Of this group, 27 patients (14.6%) had quantitatively normal scans; 8 of these patients were additionally scanned with FDG PET. Pattern analysis was performed on an individual scan basis to determine whether the metabolic changes were consistent with classic PD. Computer-assisted single-case assessments of the FDG PET scans of these 8 patients did not disclose patterns of regional metabolic change compatible with classical PD or an atypical parkinsonian variant. Similarly, network quantification revealed that PD-related pattern expression was not elevated in these patients as it was in an age- and duration-matched cohort with classical PD (P < 0.0001). None of these patients developed clinical signs of classical PD or of an atypical parkinsonian syndrome at a follow-up visit conducted 3 years after imaging. The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Eckert, Thomas" sort="Eckert, Thomas" uniqKey="Eckert T" first="Thomas" last="Eckert">Thomas Eckert</name></region><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><name sortKey="Frucht, Steven" sort="Frucht, Steven" uniqKey="Frucht S" first="Steven" last="Frucht">Steven Frucht</name><name sortKey="Lewis, Daniel E" sort="Lewis, Daniel E" uniqKey="Lewis D" first="Daniel E." last="Lewis">Daniel E. Lewis</name></country><country name="Allemagne"><noRegion><name sortKey="Eckert, Thomas" sort="Eckert, Thomas" uniqKey="Eckert T" first="Thomas" last="Eckert">Thomas Eckert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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