Bromocriptine use and the risk of valvular heart disease
Identifieur interne : 002418 ( Main/Exploration ); précédent : 002417; suivant : 002419Bromocriptine use and the risk of valvular heart disease
Auteurs : Louis C. S. Tan [Singapour] ; Kenneth K. C. Ng [Singapour] ; Wing-Lok Au [Singapour] ; Raymond K. K. Lee [Singapour] ; Yiong-Huak Chan [Singapour] ; Nigel C. K. Tan [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 5-HT2 Serotonine receptor, 5‐HT2 serotonin receptors, Aged, Aortic Valve Insufficiency (chemically induced), Aortic Valve Insufficiency (diagnosis), Aortic Valve Insufficiency (genetics), Bromocriptine, Bromocriptine (administration & dosage), Bromocriptine (adverse effects), Cardiac valvular disease, Dopamine Agonists (administration & dosage), Dopamine Agonists (adverse effects), Dopamine agonist, Dose-Response Relationship, Drug, Echocardiography, Doppler, Ergotamine, Female, Heart Valve Diseases (chemically induced), Heart Valve Diseases (diagnosis), Heart Valve Diseases (genetics), Humans, Male, Mitral Valve Insufficiency (chemically induced), Mitral Valve Insufficiency (diagnosis), Mitral Valve Insufficiency (genetics), Nervous system diseases, Parkinson Disease, Pergolide, Receptor, Serotonin, 5-HT2B (drug effects), Receptor, Serotonin, 5-HT2B (genetics), Risk Factors, Risk factor, Severity of Illness Index, Tricuspid Valve Insufficiency (chemically induced), Tricuspid Valve Insufficiency (diagnosis), Tricuspid Valve Insufficiency (genetics), bromocriptine, dopamine agonists, ergotamines, pergolide, valvular heart disease.
- MESH :
- chemical , administration & dosage : Bromocriptine, Dopamine Agonists.
- chemical , adverse effects : Bromocriptine, Dopamine Agonists.
- chemically induced : Aortic Valve Insufficiency, Heart Valve Diseases, Mitral Valve Insufficiency, Tricuspid Valve Insufficiency.
- diagnosis : Aortic Valve Insufficiency, Heart Valve Diseases, Mitral Valve Insufficiency, Tricuspid Valve Insufficiency.
- chemical , drug effects : Receptor, Serotonin, 5-HT2B.
- genetics : Aortic Valve Insufficiency, Heart Valve Diseases, Mitral Valve Insufficiency, Receptor, Serotonin, 5-HT2B, Tricuspid Valve Insufficiency.
- Aged, Dose-Response Relationship, Drug, Echocardiography, Doppler, Female, Humans, Male, Parkinson Disease, Risk Factors, Severity of Illness Index.
Abstract
It has been reported that patients on pergolide and carbergoline have an increased risk of developing valvular heart disease. It is uncertain if bromocriptine, an ergot‐derived dopamine agonist (DA) with partial 5‐HT2B activity, is associated with a similar risk. We assessed the frequency of valvular heart disease in Parkinson's disease (PD) patients on bromocriptine compared to pergolide and a control group of PD patients who had not been treated on any DA. Seventy‐two PD patients on bromocriptine, 21 patients on pergolide, and 47 control PD patients were recruited. Transthoracic echocardiographic studies were performed and reviewed by a blinded cardiologist. The risk for the bromocriptine group to develop any abnormal valvular regurgitation was 3.32 (adjusted OR, 95% CI: 1.11–9.92, P = 0.03) compared to controls, whereas the risk for the pergolide group was 3.66 (adjusted OR, 95% CI: 1.22–10.97, P = 0.02). When cumulative dose of bromocriptine was analyzed by quartiles, patients with a greater exposure to bromocriptine had significantly higher risk of developing both mild and moderate‐severe regurgitations (P for trend, 0.005 and 0.019, respectively). This study demonstrated that bromocriptine use was associated with an increased risk of developing valvular heart disease, which occurred in a cumulative dose‐dependent manner. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22228
Affiliations:
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<term>Aortic Valve Insufficiency (diagnosis)</term>
<term>Aortic Valve Insufficiency (genetics)</term>
<term>Bromocriptine</term>
<term>Bromocriptine (administration & dosage)</term>
<term>Bromocriptine (adverse effects)</term>
<term>Cardiac valvular disease</term>
<term>Dopamine Agonists (administration & dosage)</term>
<term>Dopamine Agonists (adverse effects)</term>
<term>Dopamine agonist</term>
<term>Dose-Response Relationship, Drug</term>
<term>Echocardiography, Doppler</term>
<term>Ergotamine</term>
<term>Female</term>
<term>Heart Valve Diseases (chemically induced)</term>
<term>Heart Valve Diseases (diagnosis)</term>
<term>Heart Valve Diseases (genetics)</term>
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<term>Male</term>
<term>Mitral Valve Insufficiency (chemically induced)</term>
<term>Mitral Valve Insufficiency (diagnosis)</term>
<term>Mitral Valve Insufficiency (genetics)</term>
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<term>Pergolide</term>
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<term>Receptor, Serotonin, 5-HT2B (genetics)</term>
<term>Risk Factors</term>
<term>Risk factor</term>
<term>Severity of Illness Index</term>
<term>Tricuspid Valve Insufficiency (chemically induced)</term>
<term>Tricuspid Valve Insufficiency (diagnosis)</term>
<term>Tricuspid Valve Insufficiency (genetics)</term>
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<term>dopamine agonists</term>
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<term>Tricuspid Valve Insufficiency</term>
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<term>Heart Valve Diseases</term>
<term>Mitral Valve Insufficiency</term>
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<term>Mitral Valve Insufficiency</term>
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<front><div type="abstract" xml:lang="en">It has been reported that patients on pergolide and carbergoline have an increased risk of developing valvular heart disease. It is uncertain if bromocriptine, an ergot‐derived dopamine agonist (DA) with partial 5‐HT2B activity, is associated with a similar risk. We assessed the frequency of valvular heart disease in Parkinson's disease (PD) patients on bromocriptine compared to pergolide and a control group of PD patients who had not been treated on any DA. Seventy‐two PD patients on bromocriptine, 21 patients on pergolide, and 47 control PD patients were recruited. Transthoracic echocardiographic studies were performed and reviewed by a blinded cardiologist. The risk for the bromocriptine group to develop any abnormal valvular regurgitation was 3.32 (adjusted OR, 95% CI: 1.11–9.92, P = 0.03) compared to controls, whereas the risk for the pergolide group was 3.66 (adjusted OR, 95% CI: 1.22–10.97, P = 0.02). When cumulative dose of bromocriptine was analyzed by quartiles, patients with a greater exposure to bromocriptine had significantly higher risk of developing both mild and moderate‐severe regurgitations (P for trend, 0.005 and 0.019, respectively). This study demonstrated that bromocriptine use was associated with an increased risk of developing valvular heart disease, which occurred in a cumulative dose‐dependent manner. © 2008 Movement Disorder Society</div>
</front>
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