Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
Identifieur interne : 001A34 ( Main/Exploration ); précédent : 001A33; suivant : 001A35Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
Auteurs : Claudia Schilling [Allemagne] ; Michael Schredl [Allemagne] ; Philipp Strobl [Allemagne] ; Michael Deuschle [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Cardiovascular Diseases (epidemiology), Cardiovascular Diseases (urine), Circadian Rhythm (physiology), Female, HPA system, Humans, Hydrocortisone, Hydrocortisone (urine), Male, Middle Aged, Nervous system diseases, Pituitary gland, Polysomnography, Polysomnography (methods), Restless Legs Syndrome (epidemiology), Restless Legs Syndrome (urine), Restless legs syndrome, Sex Factors, Statistics as Topic, Time Factors, cardiovascular, cortisol, polysomnography, restless legs syndrome.
- MESH :
- chemical , urine : Hydrocortisone.
- epidemiology : Cardiovascular Diseases, Restless Legs Syndrome.
- methods : Polysomnography.
- physiology : Circadian Rhythm.
- urine : Cardiovascular Diseases, Restless Legs Syndrome.
- Adult, Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Sex Factors, Statistics as Topic, Time Factors.
Abstract
Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic‐pituitary‐adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS‐induced sleep disruption to HPA system activation conceivable. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23026
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001F32
- to stream Istex, to step Curation: 001F32
- to stream Istex, to step Checkpoint: 000713
- to stream PubMed, to step Corpus: 001815
- to stream PubMed, to step Curation: 001815
- to stream PubMed, to step Checkpoint: 001640
- to stream Ncbi, to step Merge: 002B87
- to stream Ncbi, to step Curation: 002B87
- to stream Ncbi, to step Checkpoint: 002B87
- to stream Main, to step Merge: 001E70
- to stream PascalFrancis, to step Corpus: 000A56
- to stream PascalFrancis, to step Curation: 002263
- to stream PascalFrancis, to step Checkpoint: 000859
- to stream Main, to step Merge: 002446
- to stream Main, to step Curation: 001A34
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation</title><author><name sortKey="Schilling, Claudia" sort="Schilling, Claudia" uniqKey="Schilling C" first="Claudia" last="Schilling">Claudia Schilling</name></author><author><name sortKey="Schredl, Michael" sort="Schredl, Michael" uniqKey="Schredl M" first="Michael" last="Schredl">Michael Schredl</name></author><author><name sortKey="Strobl, Philipp" sort="Strobl, Philipp" uniqKey="Strobl P" first="Philipp" last="Strobl">Philipp Strobl</name></author><author><name sortKey="Deuschle, Michael" sort="Deuschle, Michael" uniqKey="Deuschle M" first="Michael" last="Deuschle">Michael Deuschle</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:78AB4FF1FF63AB03381DC1BE8469D7C8C7F2C9E1</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23026</idno><idno type="url">https://api.istex.fr/document/78AB4FF1FF63AB03381DC1BE8469D7C8C7F2C9E1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F32</idno><idno type="wicri:Area/Istex/Curation">001F32</idno><idno type="wicri:Area/Istex/Checkpoint">000713</idno><idno type="wicri:doubleKey">0885-3185:2010:Schilling C:restless:legs:syndrome</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20535825</idno><idno type="wicri:Area/PubMed/Corpus">001815</idno><idno type="wicri:Area/PubMed/Curation">001815</idno><idno type="wicri:Area/PubMed/Checkpoint">001640</idno><idno type="wicri:Area/Ncbi/Merge">002B87</idno><idno type="wicri:Area/Ncbi/Curation">002B87</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B87</idno><idno type="wicri:Area/Main/Merge">001E70</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:10-0315069</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A56</idno><idno type="wicri:Area/PascalFrancis/Curation">002263</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000859</idno><idno type="wicri:doubleKey">0885-3185:2010:Schilling C:restless:legs:syndrome</idno><idno type="wicri:Area/Main/Merge">002446</idno><idno type="wicri:Area/Main/Curation">001A34</idno><idno type="wicri:Area/Main/Exploration">001A34</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation</title><author><name sortKey="Schilling, Claudia" sort="Schilling, Claudia" uniqKey="Schilling C" first="Claudia" last="Schilling">Claudia Schilling</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Schredl, Michael" sort="Schredl, Michael" uniqKey="Schredl M" first="Michael" last="Schredl">Michael Schredl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Strobl, Philipp" sort="Strobl, Philipp" uniqKey="Strobl P" first="Philipp" last="Strobl">Philipp Strobl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Deuschle, Michael" sort="Deuschle, Michael" uniqKey="Deuschle M" first="Michael" last="Deuschle">Michael Deuschle</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-06-15">2010-06-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1047">1047</biblScope><biblScope unit="page" to="1052">1052</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">78AB4FF1FF63AB03381DC1BE8469D7C8C7F2C9E1</idno><idno type="DOI">10.1002/mds.23026</idno><idno type="ArticleID">MDS23026</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Cardiovascular Diseases (epidemiology)</term><term>Cardiovascular Diseases (urine)</term><term>Circadian Rhythm (physiology)</term><term>Female</term><term>HPA system</term><term>Humans</term><term>Hydrocortisone</term><term>Hydrocortisone (urine)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Pituitary gland</term><term>Polysomnography</term><term>Polysomnography (methods)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Restless Legs Syndrome (urine)</term><term>Restless legs syndrome</term><term>Sex Factors</term><term>Statistics as Topic</term><term>Time Factors</term><term>cardiovascular</term><term>cortisol</term><term>polysomnography</term><term>restless legs syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cardiovascular Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Polysomnography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Circadian Rhythm</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Cardiovascular Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sex Factors</term><term>Statistics as Topic</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hydrocortisone</term><term>Hypophyse</term><term>Pathologie du système nerveux</term><term>Polysomnographie</term><term>Syndrome des jambes sans repos</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic‐pituitary‐adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS‐induced sleep disruption to HPA system activation conceivable. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li></region><settlement><li>Mannheim</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schilling, Claudia" sort="Schilling, Claudia" uniqKey="Schilling C" first="Claudia" last="Schilling">Claudia Schilling</name></region><name sortKey="Deuschle, Michael" sort="Deuschle, Michael" uniqKey="Deuschle M" first="Michael" last="Deuschle">Michael Deuschle</name><name sortKey="Schredl, Michael" sort="Schredl, Michael" uniqKey="Schredl M" first="Michael" last="Schredl">Michael Schredl</name><name sortKey="Strobl, Philipp" sort="Strobl, Philipp" uniqKey="Strobl P" first="Philipp" last="Strobl">Philipp Strobl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A34 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A34 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:78AB4FF1FF63AB03381DC1BE8469D7C8C7F2C9E1
|texte= Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
}}
| This area was generated with Dilib version V0.6.23. |  |