Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
Identifieur interne : 001F32 ( Istex/Corpus ); précédent : 001F31; suivant : 001F33Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
Auteurs : Claudia Schilling ; Michael Schredl ; Philipp Strobl ; Michael DeuschleSource :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
English descriptors
Abstract
Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic‐pituitary‐adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS‐induced sleep disruption to HPA system activation conceivable. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23026
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ISTEX:78AB4FF1FF63AB03381DC1BE8469D7C8C7F2C9E1Le document en format XML
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The mechanism underlying this association is unclear. Activation of the hypothalamic‐pituitary‐adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS‐induced sleep disruption to HPA system activation conceivable. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Claudia Schilling MD</name><affiliations><json:string>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany</json:string></affiliations></json:item><json:item><name>Michael Schredl PhD</name><affiliations><json:string>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany</json:string></affiliations></json:item><json:item><name>Philipp Strobl</name><affiliations><json:string>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany</json:string></affiliations></json:item><json:item><name>Michael Deuschle MD</name><affiliations><json:string>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cortisol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>restless legs syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HPA system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cardiovascular</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>polysomnography</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. 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