MovDisordV3, PascalFrancis, Corpus, bibRecord, 000A56

Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation

Identifieur interne : 000A56 ( PascalFrancis/Corpus ); précédent : 000A55; suivant : 000A57

Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation

Auteurs : Claudia Schilling ; Michael Schredl ; Philipp Strobl ; Michael Deuschle

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0315069

Descripteurs français

Pascal (Inist)
- Syndrome des jambes sans repos, Pathologie du système nerveux, Hypophyse, Hydrocortisone, Polysomnographie.

English descriptors

KwdEn :
- Hydrocortisone, Nervous system diseases, Pituitary gland, Polysomnography, Restless legs syndrome.

Abstract

Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic-pituitary-adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation`
A11	`01`	`1`		`@1 SCHILLING (Claudia)`
A11	`02`	`1`		`@1 SCHREDL (Michael)`
A11	`03`	`1`		`@1 STROBL (Philipp)`
A11	`04`	`1`		`@1 DEUSCHLE (Michael)`
A14	`01`			`@1 Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health @2 Mannheim @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000170524820120`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 41 ref.`
A47	`01`	`1`		`@0 10-0315069`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic-pituitary-adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable.
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C03	`01`	`X`	`ENG`	`@0 Restless legs syndrome @5 01`
C03	`01`	`X`	`SPA`	`@0 Acroparestesia nocturna @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
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C03	`05`	`X`	`ENG`	`@0 Polysomnography @5 11`
C03	`05`	`X`	`SPA`	`@0 Polisomnografía @5 11`
C07	`01`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
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C07	`01`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`02`	`X`	`FRE`	`@0 Trouble de la sensibilité @5 39`
C07	`02`	`X`	`ENG`	`@0 Sensitivity disorder @5 39`
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C07	`03`	`X`	`FRE`	`@0 Glande endocrine @5 40`
C07	`03`	`X`	`ENG`	`@0 Endocrine gland @5 40`
C07	`03`	`X`	`SPA`	`@0 Glándula endocrina @5 40`
C07	`04`	`X`	`FRE`	`@0 Glucocorticoïde @5 41`
C07	`04`	`X`	`ENG`	`@0 Glucocorticoid @5 41`
C07	`04`	`X`	`SPA`	`@0 Glucocorticoide @5 41`
C07	`05`	`X`	`FRE`	`@0 Hormone surrénalienne @5 42`
C07	`05`	`X`	`ENG`	`@0 Adrenal hormone @5 42`
C07	`05`	`X`	`SPA`	`@0 Hormona suprarrenal @5 42`
N21				`@1 200`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 10-0315069 INIST
ET :	Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation
AU :	SCHILLING (Claudia); SCHREDL (Michael); STROBL (Philipp); DEUSCHLE (Michael)
AF :	Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health/Mannheim/Allemagne (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 8; Pp. 1047-1052; Bibl. 41 ref.
LA :	Anglais
EA :	Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic-pituitary-adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable.
CC :	002B17; 002B21A01
FD :	Syndrome des jambes sans repos; Pathologie du système nerveux; Hypophyse; Hydrocortisone; Polysomnographie
FG :	Trouble neurologique; Trouble de la sensibilité; Glande endocrine; Glucocorticoïde; Hormone surrénalienne
ED :	Restless legs syndrome; Nervous system diseases; Pituitary gland; Hydrocortisone; Polysomnography
EG :	Neurological disorder; Sensitivity disorder; Endocrine gland; Glucocorticoid; Adrenal hormone
SD :	Acroparestesia nocturna; Sistema nervioso patología; Hipófisis; Hidrocortisona; Polisomnografía
LO :	INIST-20953.354000170524820120
ID :	10-0315069

Links to Exploration step

Pascal:10-0315069

Le document en format XML

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<front><div type="abstract" xml:lang="en">Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic-pituitary-adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable.</div>
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<server><NO>PASCAL 10-0315069 INIST</NO>
<ET>Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation</ET>
<AU>SCHILLING (Claudia); SCHREDL (Michael); STROBL (Philipp); DEUSCHLE (Michael)</AU>
<AF>Sleep Laboratory, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health/Mannheim/Allemagne (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 8; Pp. 1047-1052; Bibl. 41 ref.</SO>
<LA>Anglais</LA>
<EA>Epidemiological studies consistently point to a relationship between restless legs syndrome (RLS) and cardiovascular disease. The mechanism underlying this association is unclear. Activation of the hypothalamic-pituitary-adrenal (HPA) system has been shown to contribute to the metabolic syndrome and an enhanced cardiovascular risk. We investigated cortisol levels as an indicator of HPA system activity in RLS during the nighttime, when RLS symptoms are at their maximum. We assessed nocturnal urinary cortisol excretion in 73 patients with RLS and 34 healthy controls, controlling for age and gender. Urine sampling was paralleled by polysomnographic recordings. We found significantly enhanced nocturnal cortisol excretion in RLS, demonstrating nocturnal HPA system overactivity in RLS. HPA system overactivity is a possible mechanism contributing to the enhanced load of cardiovascular disease in RLS patients. Nocturnal cortisol release showed weak correlations with some polysomnographic parameters of disturbed sleep, making a potential contribution of RLS-induced sleep disruption to HPA system activation conceivable.</EA>
<CC>002B17; 002B21A01</CC>
<FD>Syndrome des jambes sans repos; Pathologie du   système nerveux; Hypophyse; Hydrocortisone; Polysomnographie</FD>
<FG>Trouble neurologique; Trouble de la sensibilité; Glande endocrine; Glucocorticoïde; Hormone surrénalienne</FG>
<ED>Restless legs syndrome; Nervous system diseases; Pituitary gland; Hydrocortisone; Polysomnography</ED>
<EG>Neurological disorder; Sensitivity disorder; Endocrine gland; Glucocorticoid; Adrenal hormone</EG>
<SD>Acroparestesia nocturna; Sistema nervioso patología; Hipófisis; Hidrocortisona; Polisomnografía</SD>
<LO>INIST-20953.354000170524820120</LO>
<ID>10-0315069</ID>
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</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation

Restless Legs Syndrome: Evidence for Nocturnal Hypothalamic-Pituitary-Adrenal System Activation

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