A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome
Identifieur interne : 006203 ( Main/Curation ); précédent : 006202; suivant : 006204A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome
Auteurs : P. Brown [Royaume-Uni] ; P. D. Thompson [Royaume-Uni] ; J. C. Rothwell [Royaume-Uni] ; B. L. Day [Royaume-Uni] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1991.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Acetamides (therapeutic use), Adult, Aged, Anticonvulsants, Chemotherapy, Female, Glycine, Human, Humans, Involuntary movement, Male, Middle Aged, Milacemide, Monoamine Oxidase Inhibitors, Muscle Rigidity (drug therapy), Myoclonus, Myoclonus (drug therapy), Nervous system diseases, Neurologic Examination, Precursor, Spasm (drug therapy), Stiff man syndrome, Stiff‐person syndrome, Striated muscle disease, Syndrome, Treatment.
- MESH :
- chemical , therapeutic use : Acetamides.
- drug therapy : Muscle Rigidity, Myoclonus, Spasm.
- Adult, Aged, Anticonvulsants, Female, Humans, Male, Middle Aged, Monoamine Oxidase Inhibitors, Neurologic Examination, Syndrome.
Abstract
We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.
Url:
DOI: 10.1002/mds.870060114
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Day</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="75">75</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">021911943E4D11F8929F62806DD1B4FA67E424FD</idno><idno type="DOI">10.1002/mds.870060114</idno><idno type="ArticleID">MDS870060114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetamides (therapeutic use)</term><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Chemotherapy</term><term>Female</term><term>Glycine</term><term>Human</term><term>Humans</term><term>Involuntary movement</term><term>Male</term><term>Middle Aged</term><term>Milacemide</term><term>Monoamine Oxidase Inhibitors</term><term>Muscle Rigidity (drug therapy)</term><term>Myoclonus</term><term>Myoclonus (drug therapy)</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Precursor</term><term>Spasm (drug therapy)</term><term>Stiff man syndrome</term><term>Stiff‐person syndrome</term><term>Striated muscle disease</term><term>Syndrome</term><term>Treatment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Acetamides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Rigidity</term><term>Myoclonus</term><term>Spasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Monoamine Oxidase Inhibitors</term><term>Neurologic Examination</term><term>Syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Glycine</term><term>Homme</term><term>Homme raide syndrome</term><term>Milacémide</term><term>Mouvement involontaire</term><term>Muscle strié pathologie</term><term>Myoclonie</term><term>Précurseur</term><term>Système nerveux pathologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</div></front></TEI><double idat="0885-3185:1991:Brown P:a:therapeutic:trial"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A therapeutic trial of milacemide in myoclonus and the Stiff-Person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">91-0250791</idno><date when="1991">1991</date><idno type="stanalyst">PASCAL 91-0250791 INIST</idno><idno type="RBID">Pascal:91-0250791</idno><idno type="wicri:Area/PascalFrancis/Corpus">003904</idno><idno type="wicri:Area/PascalFrancis/Curation">002F21</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003906</idno><idno type="wicri:doubleKey">0885-3185:1991:Brown P:a:therapeutic:trial</idno><idno type="wicri:Area/Main/Merge">009578</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A therapeutic trial of milacemide in myoclonus and the Stiff-Person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="1991">1991</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemotherapy</term><term>Glycine</term><term>Human</term><term>Involuntary movement</term><term>Myoclonus</term><term>Nervous system diseases</term><term>Precursor</term><term>Stiff man syndrome</term><term>Striated muscle disease</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme raide syndrome</term><term>Myoclonie</term><term>Milacémide</term><term>Mouvement involontaire</term><term>Précurseur</term><term>Glycine</term><term>Muscle strié pathologie</term><term>Système nerveux pathologie</term><term>Traitement</term><term>Homme</term><term>Chimiothérapie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant occurred in the 10 patients</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:021911943E4D11F8929F62806DD1B4FA67E424FD</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/mds.870060114</idno><idno type="url">https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003B18</idno><idno type="wicri:Area/Istex/Curation">003B18</idno><idno type="wicri:Area/Istex/Checkpoint">004346</idno><idno type="wicri:doubleKey">0885-3185:1991:Brown P:a:therapeutic:trial</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:2005926</idno><idno type="wicri:Area/PubMed/Corpus">004E02</idno><idno type="wicri:Area/PubMed/Curation">004E02</idno><idno type="wicri:Area/PubMed/Checkpoint">004E55</idno><idno type="wicri:Area/Ncbi/Merge">002943</idno><idno type="wicri:Area/Ncbi/Curation">002943</idno><idno type="wicri:Area/Ncbi/Checkpoint">002943</idno><idno type="wicri:doubleKey">0885-3185:1991:Brown P:a:therapeutic:trial</idno><idno type="wicri:Area/Main/Merge">009507</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="75">75</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">021911943E4D11F8929F62806DD1B4FA67E424FD</idno><idno type="DOI">10.1002/mds.870060114</idno><idno type="ArticleID">MDS870060114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetamides (therapeutic use)</term><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Milacemide</term><term>Monoamine Oxidase Inhibitors</term><term>Muscle Rigidity (drug therapy)</term><term>Myoclonus</term><term>Myoclonus (drug therapy)</term><term>Neurologic Examination</term><term>Spasm (drug therapy)</term><term>Stiff‐person syndrome</term><term>Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Acetamides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Rigidity</term><term>Myoclonus</term><term>Spasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Monoamine Oxidase Inhibitors</term><term>Neurologic Examination</term><term>Syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</div></front></TEI></ISTEX></double></record>Pour manipuler ce document sous Unix (Dilib)
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