A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.
Identifieur interne : 002943 ( Ncbi/Merge ); précédent : 002942; suivant : 002944A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.
Auteurs : P. Brown [Royaume-Uni] ; P D Thompson ; J C Rothwell ; B L Day ; C D MarsdenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Acetamides.
- drug therapy : Muscle Rigidity, Myoclonus, Spasm.
- Adult, Aged, Anticonvulsants, Female, Humans, Male, Middle Aged, Monoamine Oxidase Inhibitors, Neurologic Examination, Syndrome.
Abstract
We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.
DOI: 10.1002/mds.870060114
PubMed: 2005926
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pubmed:2005926Le document en format XML
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Brown</name><affiliation wicri:level="2"><nlm:affiliation>MRC Human Movement and Balance Unit, Institute of Neurology, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P D" last="Thompson">P D Thompson</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J C" last="Rothwell">J C Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B L" last="Day">B L Day</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:2005926</idno><idno type="pmid">2005926</idno><idno type="doi">10.1002/mds.870060114</idno><idno type="wicri:Area/PubMed/Corpus">004E02</idno><idno type="wicri:Area/PubMed/Curation">004E02</idno><idno type="wicri:Area/PubMed/Checkpoint">004E55</idno><idno type="wicri:Area/Ncbi/Merge">002943</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="2"><nlm:affiliation>MRC Human Movement and Balance Unit, Institute of Neurology, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P D" last="Thompson">P D Thompson</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J C" last="Rothwell">J C Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B L" last="Day">B L Day</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetamides (therapeutic use)</term><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Monoamine Oxidase Inhibitors</term><term>Muscle Rigidity (drug therapy)</term><term>Myoclonus (drug therapy)</term><term>Neurologic Examination</term><term>Spasm (drug therapy)</term><term>Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Acetamides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Rigidity</term><term>Myoclonus</term><term>Spasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anticonvulsants</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Monoamine Oxidase Inhibitors</term><term>Neurologic Examination</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2005926</PMID><DateCreated><Year>1991</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>1991</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>1991</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.</ArticleTitle><Pagination><MedlinePgn>73-5</MedlinePgn></Pagination><Abstract><AbstractText>We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC Human Movement and Balance Unit, Institute of Neurology, London, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>P D</ForeName><Initials>PD</Initials></Author><Author ValidYN="Y"><LastName>Rothwell</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Day</LastName><ForeName>B L</ForeName><Initials>BL</Initials></Author><Author ValidYN="Y"><LastName>Marsden</LastName><ForeName>C D</ForeName><Initials>CD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000081">Acetamides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000927">Anticonvulsants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008996">Monoamine Oxidase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0HXT24RECU</RegistryNumber><NameOfSubstance UI="C039332">milacemide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000081">Acetamides</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D000927">Anticonvulsants</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008996">Monoamine Oxidase Inhibitors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009127">Muscle Rigidity</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009207">Myoclonus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013035">Spasm</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013577">Syndrome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2005926</ArticleId><ArticleId IdType="doi">10.1002/mds.870060114</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><noCountry><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B L" last="Day">B L Day</name><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J C" last="Rothwell">J C Rothwell</name><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P D" last="Thompson">P D Thompson</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. 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