A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome
Identifieur interne : 003B18 ( Istex/Corpus ); précédent : 003B17; suivant : 003B19A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome
Auteurs : P. Brown ; P. D. Thompson ; J. C. Rothwell ; B. L. Day ; MarsdenSource :
- Movement Disorders [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
Abstract
We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.
Url:
DOI: 10.1002/mds.870060114
Links to Exploration step
ISTEX:021911943E4D11F8929F62806DD1B4FA67E424FDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:021911943E4D11F8929F62806DD1B4FA67E424FD</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/mds.870060114</idno><idno type="url">https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003B18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation><mods:affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="75">75</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">021911943E4D11F8929F62806DD1B4FA67E424FD</idno><idno type="DOI">10.1002/mds.870060114</idno><idno type="ArticleID">MDS870060114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Milacemide</term><term>Myoclonus</term><term>Stiff‐person syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>P. Brown</name><affiliations><json:string>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</json:string></affiliations></json:item><json:item><name>P. D. Thompson</name><affiliations><json:string>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</json:string></affiliations></json:item><json:item><name>J. C. Rothwell</name><affiliations><json:string>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</json:string></affiliations></json:item><json:item><name>B. L. Day</name><affiliations><json:string>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</json:string></affiliations></json:item><json:item><name>Prof. Marsden</name><affiliations><json:string>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Myoclonus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stiff‐person syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Milacemide</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</abstract><qualityIndicators><score>2.09</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>320</abstractCharCount><pdfWordCount>1514</pdfWordCount><pdfCharCount>10430</pdfCharCount><pdfPageCount>3</pdfPageCount><abstractWordCount>48</abstractWordCount></qualityIndicators><title>A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><genre><json:string>Serial article</json:string></genre><host><volume>6</volume><pages><total>3</total><last>75</last><first>73</first></pages><issn><json:string>0885-3185</json:string></issn><issue>1</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><doi><json:string>10.1002/mds.870060114</json:string></doi><id>021911943E4D11F8929F62806DD1B4FA67E424FD</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>1991</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><author><persName><forename type="first">P.</forename><surname>Brown</surname></persName><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation></author><author><persName><forename type="first">P. D.</forename><surname>Thompson</surname></persName><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation></author><author><persName><forename type="first">J. C.</forename><surname>Rothwell</surname></persName><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation></author><author><persName><forename type="first">B. L.</forename><surname>Day</surname></persName><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation></author><author><persName><surname>Marsden</surname><roleName type="degree">Prof.</roleName></persName><note type="correspondence"><p>Correspondence: University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, WC1N 3BG, England</p></note><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991"></date><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="75">75</biblScope></imprint></monogr><idno type="istex">021911943E4D11F8929F62806DD1B4FA67E424FD</idno><idno type="DOI">10.1002/mds.870060114</idno><idno type="ArticleID">MDS870060114</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1991</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Myoclonus</term></item><item><term>Stiff‐person syndrome</term></item><item><term>Milacemide</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/021911943E4D11F8929F62806DD1B4FA67E424FD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mds.v6:1</doi><numberingGroup><numbering type="journalVolume" number="6">6</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1991">1991</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="14" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.870060114</doi><idGroup><id type="unit" value="MDS870060114"></id></idGroup><countGroup><count type="pageTotal" number="3"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 1991 Movement Disorder Society</copyright><eventGroup><event type="firstOnline" date="2004-10-12"></event><event type="publishedOnlineFinalForm" date="2004-10-12"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">73</numbering><numbering type="pageLast">75</numbering></numberingGroup><correspondenceTo>University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, WC1N 3BG, England</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS870060114.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="18"></count></countGroup><titleGroup><title type="main" xml:lang="en">A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title><title type="short" xml:lang="en">MILACEMIDE IN MYOCLONUS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>P.</givenNames><familyName>Brown</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>P. D.</givenNames><familyName>Thompson</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>J. C.</givenNames><familyName>Rothwell</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>B. L.</givenNames><familyName>Day</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Prof.</honorifics><givenNames>C. D.</givenNames><familyName>Marsden</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Myoclonus</keyword><keyword xml:id="kwd2">Stiff‐person syndrome</keyword><keyword xml:id="kwd3">Milacemide</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MILACEMIDE IN MYOCLONUS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Brown</namePart><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Thompson</namePart><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Rothwell</namePart><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. L.</namePart><namePart type="family">Day</namePart><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof.</namePart><namePart type="family">Marsden</namePart><affiliation>MRC Human Movement and Balance Unit, and University Department of Clinical Neurology, Institute of Neurology, London, England</affiliation><description>Correspondence: University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, WC1N 3BG, England</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1991</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">18</extent></physicalDescription><abstract lang="en">We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff‐person syndrome in an open‐label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.</abstract><subject lang="en"><genre>Keywords</genre><topic>Myoclonus</topic><topic>Stiff‐person syndrome</topic><topic>Milacemide</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>73</start><end>75</end><total>3</total></extent></part></relatedItem><identifier type="istex">021911943E4D11F8929F62806DD1B4FA67E424FD</identifier><identifier type="DOI">10.1002/mds.870060114</identifier><identifier type="ArticleID">MDS870060114</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1991 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003B18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:021911943E4D11F8929F62806DD1B4FA67E424FD
|texte= A therapeutic trial of milacemide in myoclonus and the stiff‐person syndrome
}}
| This area was generated with Dilib version V0.6.23. |  |