Postprandial hypotension and parkinsonian state in parkinson's disease
Identifieur interne : 005285 ( Main/Curation ); précédent : 005284; suivant : 005286Postprandial hypotension and parkinsonian state in parkinson's disease
Auteurs : Chaudhuri [Royaume-Uni] ; Catherine Ellis [Royaume-Uni] ; Sarah Love-Jones [Royaume-Uni] ; Thomas Thomaides [Royaume-Uni] ; Susan Clift [Royaume-Uni] ; Christopher J. Mathias [Royaume-Uni] ; J. David Parkes [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-11.
English descriptors
- KwdEn :
- Actimetry, Adult, Aged, Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (physiopathology), Blood Glucose, Energy Intake, Gut peptides, Humans, Hypotension (complications), Hypotension (diagnosis), Idiopathic Parkinson's disease, Insulin (blood), Male, Middle Aged, Motor Activity, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease, Secondary (complications), Parkinson Disease, Secondary (physiopathology), Postprandial hypotension, Postural hypotension, Severity of Illness Index, Splanchnic, Time Factors.
- MESH :
- chemical , blood : Insulin.
- chemical : Blood Glucose.
- complications : Autonomic Nervous System Diseases, Hypotension, Parkinson Disease, Parkinson Disease, Secondary.
- diagnosis : Hypotension.
- physiopathology : Autonomic Nervous System Diseases, Parkinson Disease, Parkinson Disease, Secondary.
- Adult, Aged, Energy Intake, Humans, Male, Middle Aged, Motor Activity, Severity of Illness Index, Time Factors.
Abstract
Abnormal postprandial cardiovascular responses such as postprandial hypotension (PPH) occur in primary autonomic failure and contribute significantly to morbidity. The extent and frequency of PPH and its relationship to the parkinsonian state in idiopathic Parkinson's disease (IPD) is unknown. By studying 20 patients with IPD (without autonomic failure) and 16 age‐matched controls after both groups ingested a standard isocaloric balanced liquid meal we have shown that supine PPH complicates IPD and is reduced to marked worsening of the parkinsonian state as measured by a cumulative score of tremor, rigidity, bradykinesia, posture, and gait, Furthermore, significant postural hypotension is unmasked that results in posturnal intolerance due to presyncopal symptoms. Our study in posturnal intolerance due to presyncopal symptoms. Our study indicates that, in patients with IPD, ingestion of a meal may lead to abnormal postprandial cardiovascular responsea and aggravation of the parkinsonian state. The underlying mechanisms are unclear, although vasodilatory gut peptides released in response to food ingestion may be contributory.
Url:
DOI: 10.1002/mds.870120608
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London SE5 8AF</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-11">1997-11</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="877">877</biblScope><biblScope unit="page" to="884">884</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EBC996271BF40852ABFE83D9A4956490B9BD50DB</idno><idno type="DOI">10.1002/mds.870120608</idno><idno type="ArticleID">MDS870120608</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actimetry</term><term>Adult</term><term>Aged</term><term>Autonomic Nervous System Diseases (complications)</term><term>Autonomic Nervous System Diseases (physiopathology)</term><term>Blood Glucose</term><term>Energy Intake</term><term>Gut peptides</term><term>Humans</term><term>Hypotension (complications)</term><term>Hypotension (diagnosis)</term><term>Idiopathic Parkinson's disease</term><term>Insulin (blood)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease, Secondary (complications)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Postprandial hypotension</term><term>Postural hypotension</term><term>Severity of Illness Index</term><term>Splanchnic</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Hypotension</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Energy Intake</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abnormal postprandial cardiovascular responses such as postprandial hypotension (PPH) occur in primary autonomic failure and contribute significantly to morbidity. The extent and frequency of PPH and its relationship to the parkinsonian state in idiopathic Parkinson's disease (IPD) is unknown. By studying 20 patients with IPD (without autonomic failure) and 16 age‐matched controls after both groups ingested a standard isocaloric balanced liquid meal we have shown that supine PPH complicates IPD and is reduced to marked worsening of the parkinsonian state as measured by a cumulative score of tremor, rigidity, bradykinesia, posture, and gait, Furthermore, significant postural hypotension is unmasked that results in posturnal intolerance due to presyncopal symptoms. Our study in posturnal intolerance due to presyncopal symptoms. Our study indicates that, in patients with IPD, ingestion of a meal may lead to abnormal postprandial cardiovascular responsea and aggravation of the parkinsonian state. The underlying mechanisms are unclear, although vasodilatory gut peptides released in response to food ingestion may be contributory.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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