Interaction of levodopa and cues on voluntary reaching in Parkinson's disease
Identifieur interne : 002727 ( PascalFrancis/Checkpoint ); précédent : 002726; suivant : 002728Interaction of levodopa and cues on voluntary reaching in Parkinson's disease
Auteurs : Valerie E. Kelly [États-Unis] ; Allie S. Hyngstrom [États-Unis] ; Melissa M. Rundle [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
English descriptors
- KwdEn :
Abstract
The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.
Affiliations:
- États-Unis
- Missouri (État)
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
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Kelly</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Physical Therapy, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hyngstrom, Allie S" sort="Hyngstrom, Allie S" uniqKey="Hyngstrom A" first="Allie S." last="Hyngstrom">Allie S. Hyngstrom</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Physical Therapy, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Rundle, Melissa M" sort="Rundle, Melissa M" uniqKey="Rundle M" first="Melissa M." last="Rundle">Melissa M. Rundle</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Movement Disorders Center, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Physical Therapy, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Movement Disorders Center, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Anatomy and Neurobiology, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson agent</term><term>Body movement</term><term>Chemotherapy</term><term>Elderly</term><term>Kinematics</term><term>Levodopa</term><term>Light stimulus</term><term>Parkinson disease</term><term>Performance evaluation</term><term>Reachability</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Lévodopa</term><term>Chimiothérapie</term><term>Antiparkinsonien</term><term>Cinématique</term><term>Mouvement corporel</term><term>Atteignabilité</term><term>Stimulus lumineux</term><term>Evaluation performance</term><term>Traitement</term><term>Personne âgée</term><term>Bradykinésie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>17</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Interaction of levodopa and cues on voluntary reaching in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>KELLY (Valerie E.)</s1></fA11><fA11 i1="02" i2="1"><s1>HYNGSTROM (Allie S.)</s1></fA11><fA11 i1="03" i2="1"><s1>RUNDLE (Melissa M.)</s1></fA11><fA11 i1="04" i2="1"><s1>BASTIAN (Amy J.)</s1></fA11><fA14 i1="01"><s1>Program in Physical Therapy, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Movement Disorders Center, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Anatomy and Neurobiology, Washington University School of Medicine</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA20><s1>38-44</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000100147290070</s5></fA43><fA44><s0>0000</s0><s1>© 2002 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>15 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>02-0206587</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Lévodopa</s0><s2>NK</s2><s2>FR</s2><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Chimiothérapie</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Chemotherapy</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Quimioterapia</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Antiparkinsonien</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Antiparkinson agent</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Antiparkinsoniano</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Cinématique</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Kinematics</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Cinemática</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Mouvement corporel</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Body movement</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Movimiento corporal</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Atteignabilité</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Reachability</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Asequibilidad</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Stimulus lumineux</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Light stimulus</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Estímulo luminoso</s0><s5>13</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Evaluation performance</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Performance evaluation</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Evaluación prestación</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Traitement</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Treatment</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Personne âgée</s0><s5>20</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Elderly</s0><s5>20</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Anciano</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Bradykinésie</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>42</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>42</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>42</s5></fC07><fN21><s1>119</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Kelly, Valerie E" sort="Kelly, Valerie E" uniqKey="Kelly V" first="Valerie E." last="Kelly">Valerie E. Kelly</name></region><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Hyngstrom, Allie S" sort="Hyngstrom, Allie S" uniqKey="Hyngstrom A" first="Allie S." last="Hyngstrom">Allie S. Hyngstrom</name><name sortKey="Rundle, Melissa M" sort="Rundle, Melissa M" uniqKey="Rundle M" first="Melissa M." last="Rundle">Melissa M. Rundle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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