Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy
Identifieur interne : 003535 ( Main/Curation ); précédent : 003534; suivant : 003536Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy
Auteurs : David Millar [Royaume-Uni] ; Philipa Griffiths [Royaume-Uni] ; Adam J. Zermansky [Royaume-Uni] ; David J. Burn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-02.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adjustment, Affective Symptoms (diagnosis), Affective Symptoms (physiopathology), Affective Symptoms (psychology), Aged, Attention (physiology), Awareness (physiology), Cognition Disorders (diagnosis), Cognition Disorders (physiopathology), Cognition Disorders (psychology), Female, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Katz Adjustment Scale‐Relatives, Male, Mental Disorders (diagnosis), Mental Disorders (physiopathology), Mental Disorders (psychology), Middle Aged, Nervous system diseases, Neurologic Examination, Neuropsychological Tests, PSP, Personality Assessment, Prefrontal Cortex (physiopathology), Problem Solving (physiology), Reaction Time (physiology), Set (Psychology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (psychology), Verbal Behavior (physiology), dysexecutive syndrome.
- MESH :
- diagnosis : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- physiology : Attention, Awareness, Problem Solving, Reaction Time, Verbal Behavior.
- physiopathology : Affective Symptoms, Cognition Disorders, Frontal Lobe, Gyrus Cinguli, Mental Disorders, Prefrontal Cortex, Supranuclear Palsy, Progressive.
- psychology : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Personality Assessment, Set (Psychology).
Abstract
Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale‐Relatives (KAS‐R), an instrument first developed to assess dysexecutive changes in head‐injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS‐R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20707
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Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale‐Relatives (KAS‐R), an instrument first developed to assess dysexecutive changes in head‐injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS‐R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease. © 2005 Movement Disorder Society</div></front></TEI><double idat="0885-3185:2006:Millar D:characterizing:behavioral:and"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy</title><author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Psychology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuropsychology, Regional Neurological Rehabilitation Centre</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J." last="Zermansky">Adam J. Zermansky</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0171945</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0171945 INIST</idno><idno type="RBID">Pascal:06-0171945</idno><idno type="wicri:Area/PascalFrancis/Corpus">001C60</idno><idno type="wicri:Area/PascalFrancis/Curation">001061</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001B86</idno><idno type="wicri:doubleKey">0885-3185:2006:Millar D:characterizing:behavioral:and</idno><idno type="wicri:Area/Main/Merge">004C81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy</title><author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Psychology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuropsychology, Regional Neurological Rehabilitation Centre</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J." last="Zermansky">Adam J. Zermansky</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurology, University of Newcastle upon Tyne</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjustment</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Réglage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy</title><author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name></author><author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name></author><author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J." last="Zermansky">Adam J. Zermansky</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:306C063732AF9B8B5021274C2DEF55FB04C5E7E7</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20707</idno><idno type="url">https://api.istex.fr/document/306C063732AF9B8B5021274C2DEF55FB04C5E7E7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E17</idno><idno type="wicri:Area/Istex/Curation">000E17</idno><idno type="wicri:Area/Istex/Checkpoint">001F95</idno><idno type="wicri:doubleKey">0885-3185:2006:Millar D:characterizing:behavioral:and</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16200534</idno><idno type="wicri:Area/PubMed/Corpus">002E64</idno><idno type="wicri:Area/PubMed/Curation">002E64</idno><idno type="wicri:Area/PubMed/Checkpoint">002E23</idno><idno type="wicri:Area/Ncbi/Merge">001448</idno><idno type="wicri:Area/Ncbi/Curation">001448</idno><idno type="wicri:Area/Ncbi/Checkpoint">001448</idno><idno type="wicri:doubleKey">0885-3185:2006:Millar D:characterizing:behavioral:and</idno><idno type="wicri:Area/Main/Merge">004849</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy</title><author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuropsychology, Regional Neurological Rehabilitation Centre, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J." last="Zermansky">Adam J. Zermansky</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-02">2006-02</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="207">207</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">306C063732AF9B8B5021274C2DEF55FB04C5E7E7</idno><idno type="DOI">10.1002/mds.20707</idno><idno type="ArticleID">MDS20707</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affective Symptoms (diagnosis)</term><term>Affective Symptoms (physiopathology)</term><term>Affective Symptoms (psychology)</term><term>Aged</term><term>Attention (physiology)</term><term>Awareness (physiology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (physiopathology)</term><term>Cognition Disorders (psychology)</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Katz Adjustment Scale‐Relatives</term><term>Male</term><term>Mental Disorders (diagnosis)</term><term>Mental Disorders (physiopathology)</term><term>Mental Disorders (psychology)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>PSP</term><term>Personality Assessment</term><term>Prefrontal Cortex (physiopathology)</term><term>Problem Solving (physiology)</term><term>Reaction Time (physiology)</term><term>Set (Psychology)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Supranuclear Palsy, Progressive (psychology)</term><term>Verbal Behavior (physiology)</term><term>dysexecutive syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Mental Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Awareness</term><term>Problem Solving</term><term>Reaction Time</term><term>Verbal Behavior</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Mental Disorders</term><term>Prefrontal Cortex</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Mental Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Personality Assessment</term><term>Set (Psychology)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale‐Relatives (KAS‐R), an instrument first developed to assess dysexecutive changes in head‐injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS‐R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease. © 2005 Movement Disorder Society</div></front></TEI></ISTEX></double></record>Pour manipuler ce document sous Unix (Dilib)
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