Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.
Identifieur interne : 001448 ( Ncbi/Checkpoint ); précédent : 001447; suivant : 001449Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.
Auteurs : David Millar [Royaume-Uni] ; Philipa Griffiths ; Adam J. Zermansky ; David J. BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Affective Symptoms (diagnosis), Affective Symptoms (physiopathology), Affective Symptoms (psychology), Aged, Attention (physiology), Awareness (physiology), Cognition Disorders (diagnosis), Cognition Disorders (physiopathology), Cognition Disorders (psychology), Female, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Male, Mental Disorders (diagnosis), Mental Disorders (physiopathology), Mental Disorders (psychology), Middle Aged, Neurologic Examination, Neuropsychological Tests, Personality Assessment, Prefrontal Cortex (physiopathology), Problem Solving (physiology), Reaction Time (physiology), Set (Psychology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (psychology), Verbal Behavior (physiology).
- MESH :
- diagnosis : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- physiology : Attention, Awareness, Problem Solving, Reaction Time, Verbal Behavior.
- physiopathology : Affective Symptoms, Cognition Disorders, Frontal Lobe, Gyrus Cinguli, Mental Disorders, Prefrontal Cortex, Supranuclear Palsy, Progressive.
- psychology : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Personality Assessment, Set (Psychology).
Abstract
Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.
DOI: 10.1002/mds.20707
PubMed: 16200534
Affiliations:
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Zermansky</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20707</idno><idno type="RBID">pubmed:16200534</idno><idno type="pmid">16200534</idno><idno type="wicri:Area/PubMed/Corpus">002E64</idno><idno type="wicri:Area/PubMed/Curation">002E64</idno><idno type="wicri:Area/PubMed/Checkpoint">002E23</idno><idno type="wicri:Area/Ncbi/Merge">001448</idno><idno type="wicri:Area/Ncbi/Curation">001448</idno><idno type="wicri:Area/Ncbi/Checkpoint">001448</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.</title><author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. david.millar@nap.nhs.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name></author><author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J" last="Zermansky">Adam J. Zermansky</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affective Symptoms (diagnosis)</term><term>Affective Symptoms (physiopathology)</term><term>Affective Symptoms (psychology)</term><term>Aged</term><term>Attention (physiology)</term><term>Awareness (physiology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (physiopathology)</term><term>Cognition Disorders (psychology)</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Male</term><term>Mental Disorders (diagnosis)</term><term>Mental Disorders (physiopathology)</term><term>Mental Disorders (psychology)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Personality Assessment</term><term>Prefrontal Cortex (physiopathology)</term><term>Problem Solving (physiology)</term><term>Reaction Time (physiology)</term><term>Set (Psychology)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Supranuclear Palsy, Progressive (psychology)</term><term>Verbal Behavior (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Mental Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Awareness</term><term>Problem Solving</term><term>Reaction Time</term><term>Verbal Behavior</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Mental Disorders</term><term>Prefrontal Cortex</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Affective Symptoms</term><term>Cognition Disorders</term><term>Mental Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Personality Assessment</term><term>Set (Psychology)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J" last="Zermansky">Adam J. Zermansky</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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