Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.
Identifieur interne : 002E23 ( PubMed/Checkpoint ); précédent : 002E22; suivant : 002E24Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.
Auteurs : David Millar [Royaume-Uni] ; Philipa Griffiths ; Adam J. Zermansky ; David J. BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Affective Symptoms (diagnosis), Affective Symptoms (physiopathology), Affective Symptoms (psychology), Aged, Attention (physiology), Awareness (physiology), Cognition Disorders (diagnosis), Cognition Disorders (physiopathology), Cognition Disorders (psychology), Female, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Male, Mental Disorders (diagnosis), Mental Disorders (physiopathology), Mental Disorders (psychology), Middle Aged, Neurologic Examination, Neuropsychological Tests, Personality Assessment, Prefrontal Cortex (physiopathology), Problem Solving (physiology), Reaction Time (physiology), Set (Psychology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (psychology), Verbal Behavior (physiology).
- MESH :
- diagnosis : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- physiology : Attention, Awareness, Problem Solving, Reaction Time, Verbal Behavior.
- physiopathology : Affective Symptoms, Cognition Disorders, Frontal Lobe, Gyrus Cinguli, Mental Disorders, Prefrontal Cortex, Supranuclear Palsy, Progressive.
- psychology : Affective Symptoms, Cognition Disorders, Mental Disorders, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Personality Assessment, Set (Psychology).
Abstract
Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.
DOI: 10.1002/mds.20707
PubMed: 16200534
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:16200534Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.</title>
<author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. david.millar@nap.nhs.uk</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name>
</author>
<author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J" last="Zermansky">Adam J. Zermansky</name>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="doi">10.1002/mds.20707</idno>
<idno type="RBID">pubmed:16200534</idno>
<idno type="pmid">16200534</idno>
<idno type="wicri:Area/PubMed/Corpus">002E64</idno>
<idno type="wicri:Area/PubMed/Curation">002E64</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002E23</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.</title>
<author><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. david.millar@nap.nhs.uk</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name>
</author>
<author><name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J" last="Zermansky">Adam J. Zermansky</name>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affective Symptoms (diagnosis)</term>
<term>Affective Symptoms (physiopathology)</term>
<term>Affective Symptoms (psychology)</term>
<term>Aged</term>
<term>Attention (physiology)</term>
<term>Awareness (physiology)</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Female</term>
<term>Frontal Lobe (physiopathology)</term>
<term>Gyrus Cinguli (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Disorders (diagnosis)</term>
<term>Mental Disorders (physiopathology)</term>
<term>Mental Disorders (psychology)</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Neuropsychological Tests</term>
<term>Personality Assessment</term>
<term>Prefrontal Cortex (physiopathology)</term>
<term>Problem Solving (physiology)</term>
<term>Reaction Time (physiology)</term>
<term>Set (Psychology)</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Supranuclear Palsy, Progressive (psychology)</term>
<term>Verbal Behavior (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Affective Symptoms</term>
<term>Cognition Disorders</term>
<term>Mental Disorders</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term>
<term>Awareness</term>
<term>Problem Solving</term>
<term>Reaction Time</term>
<term>Verbal Behavior</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Affective Symptoms</term>
<term>Cognition Disorders</term>
<term>Frontal Lobe</term>
<term>Gyrus Cinguli</term>
<term>Mental Disorders</term>
<term>Prefrontal Cortex</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Affective Symptoms</term>
<term>Cognition Disorders</term>
<term>Mental Disorders</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Neuropsychological Tests</term>
<term>Personality Assessment</term>
<term>Set (Psychology)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16200534</PMID>
<DateCreated><Year>2006</Year>
<Month>02</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2006</Year>
<Month>09</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>21</Volume>
<Issue>2</Issue>
<PubDate><Year>2006</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.</ArticleTitle>
<Pagination><MedlinePgn>199-207</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.</AbstractText>
<CopyrightInformation>Copyright (c) 2005 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Millar</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. david.millar@nap.nhs.uk</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Griffiths</LastName>
<ForeName>Philipa</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zermansky</LastName>
<ForeName>Adam J</ForeName>
<Initials>AJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Burn</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000342">Affective Symptoms</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001288">Attention</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001364">Awareness</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005625">Frontal Lobe</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006179">Gyrus Cinguli</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001523">Mental Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010552">Personality Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017397">Prefrontal Cortex</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011340">Problem Solving</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012718">Set (Psychology)</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D013494">Supranuclear Palsy, Progressive</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014705">Verbal Behavior</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>10</Month>
<Day>4</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2006</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>10</Month>
<Day>4</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.20707</ArticleId>
<ArticleId IdType="pubmed">16200534</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
</list>
<tree><noCountry><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
<name sortKey="Griffiths, Philipa" sort="Griffiths, Philipa" uniqKey="Griffiths P" first="Philipa" last="Griffiths">Philipa Griffiths</name>
<name sortKey="Zermansky, Adam J" sort="Zermansky, Adam J" uniqKey="Zermansky A" first="Adam J" last="Zermansky">Adam J. Zermansky</name>
</noCountry>
<country name="Royaume-Uni"><noRegion><name sortKey="Millar, David" sort="Millar, David" uniqKey="Millar D" first="David" last="Millar">David Millar</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E23 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002E23 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:16200534 |texte= Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:16200534" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |