Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Identifieur interne : 003421 ( Main/Curation ); précédent : 003420; suivant : 003422Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Auteurs : Dominique Caparros-Lefebvre [France] ; John Steele [États-Unis] ; Yaichiro Kotake [Japon] ; Shigeru Ohta [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Descripteurs français
- Wicri :
- geographic : Japon.
- topic : Guadeloupe, Guam.
English descriptors
- KwdEn :
- Acetogenins, Amino Acids, Diamino (toxicity), Annonaceae (toxicity), Drug Synergism, Fatty Alcohols (toxicity), Guadeloupe, Guam, Humans, Japan, Lactones (toxicity), Motor Neuron Disease (chemically induced), Motor Neuron Disease (epidemiology), Neurotoxins (toxicity), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (epidemiology), Rotenone (toxicity), Tauopathies (chemically induced), Tropical Climate, annonaceae acetogenins, atypical Parkinsonism, rotenone.
- MESH :
- chemical , toxicity : Amino Acids, Diamino, Fatty Alcohols, Lactones, Neurotoxins, Rotenone.
- chemical : Acetogenins.
- geographic : Guadeloupe, Guam, Japan.
- chemically induced : Motor Neuron Disease, Parkinson Disease, Secondary, Tauopathies.
- epidemiology : Motor Neuron Disease, Parkinson Disease, Secondary.
- toxicity : Annonaceae.
- Drug Synergism, Humans, Tropical Climate.
Abstract
Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. It was first described on Guam, later in New Guinea and in the Kii peninsula, on Guadeloupe, and in New Caledonia. We investigated the phenotype of atypical Parkinsonism in three of these foci and observed several similarities with dementia in most and amyotrophic lateral sclerosis in some. This disappearance of this disease in two places—Guam and New Guinea—suggested an environmental origin which has not been clarified before the disease ended. The exposure to annonaceae acetogenins and/or rotenone has been documented in four of these places, and experimental studies in animals demonstrated annonaceae acetogenins neurotoxicity, which is similar to rotenone neurotoxicity. Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21024
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F33
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :002F33
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001E81
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002B42
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002B42
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002D12
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001796
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001796
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001796
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004735
Links to Exploration step
ISTEX:120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins</title>
<author><name sortKey="Caparros Efebvre, Dominique" sort="Caparros Efebvre, Dominique" uniqKey="Caparros Efebvre D" first="Dominique" last="Caparros-Lefebvre">Dominique Caparros-Lefebvre</name>
</author>
<author><name sortKey="Steele, John" sort="Steele, John" uniqKey="Steele J" first="John" last="Steele">John Steele</name>
</author>
<author><name sortKey="Kotake, Yaichiro" sort="Kotake, Yaichiro" uniqKey="Kotake Y" first="Yaichiro" last="Kotake">Yaichiro Kotake</name>
</author>
<author><name sortKey="Ohta, Shigeru" sort="Ohta, Shigeru" uniqKey="Ohta S" first="Shigeru" last="Ohta">Shigeru Ohta</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDD</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.21024</idno>
<idno type="url">https://api.istex.fr/document/120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDD/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002F33</idno>
<idno type="wicri:Area/Istex/Curation">002F33</idno>
<idno type="wicri:Area/Istex/Checkpoint">001E81</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Caparros Efebvre D:geographic:isolates:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16874753</idno>
<idno type="wicri:Area/PubMed/Corpus">002B42</idno>
<idno type="wicri:Area/PubMed/Curation">002B42</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002D12</idno>
<idno type="wicri:Area/Ncbi/Merge">001796</idno>
<idno type="wicri:Area/Ncbi/Curation">001796</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001796</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Caparros Lefebvre D:geographic:isolates:of</idno>
<idno type="wicri:Area/Main/Merge">004735</idno>
<idno type="wicri:Area/Main/Curation">003421</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins</title>
<author><name sortKey="Caparros Efebvre, Dominique" sort="Caparros Efebvre, Dominique" uniqKey="Caparros Efebvre D" first="Dominique" last="Caparros-Lefebvre">Dominique Caparros-Lefebvre</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier de Valenciennes, Val d'Escaut</wicri:regionArea>
<wicri:noRegion>Val d'Escaut</wicri:noRegion>
<wicri:noRegion>Val d'Escaut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Steele, John" sort="Steele, John" uniqKey="Steele J" first="John" last="Steele">John Steele</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Micronesian Health Study II, Tamuning, Guam</wicri:regionArea>
<wicri:noRegion>Guam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kotake, Yaichiro" sort="Kotake, Yaichiro" uniqKey="Kotake Y" first="Yaichiro" last="Kotake">Yaichiro Kotake</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Minami‐ku, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ohta, Shigeru" sort="Ohta, Shigeru" uniqKey="Ohta S" first="Shigeru" last="Ohta">Shigeru Ohta</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Minami‐ku, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-10">2006-10</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1769">1769</biblScope>
<biblScope unit="page" to="1771">1771</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDD</idno>
<idno type="DOI">10.1002/mds.21024</idno>
<idno type="ArticleID">MDS21024</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetogenins</term>
<term>Amino Acids, Diamino (toxicity)</term>
<term>Annonaceae (toxicity)</term>
<term>Drug Synergism</term>
<term>Fatty Alcohols (toxicity)</term>
<term>Guadeloupe</term>
<term>Guam</term>
<term>Humans</term>
<term>Japan</term>
<term>Lactones (toxicity)</term>
<term>Motor Neuron Disease (chemically induced)</term>
<term>Motor Neuron Disease (epidemiology)</term>
<term>Neurotoxins (toxicity)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (epidemiology)</term>
<term>Rotenone (toxicity)</term>
<term>Tauopathies (chemically induced)</term>
<term>Tropical Climate</term>
<term>annonaceae acetogenins</term>
<term>atypical Parkinsonism</term>
<term>rotenone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Amino Acids, Diamino</term>
<term>Fatty Alcohols</term>
<term>Lactones</term>
<term>Neurotoxins</term>
<term>Rotenone</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acetogenins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Guadeloupe</term>
<term>Guam</term>
<term>Japan</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Guadeloupe</term>
<term>Guam</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Motor Neuron Disease</term>
<term>Parkinson Disease, Secondary</term>
<term>Tauopathies</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Motor Neuron Disease</term>
<term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Annonaceae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Synergism</term>
<term>Humans</term>
<term>Tropical Climate</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. It was first described on Guam, later in New Guinea and in the Kii peninsula, on Guadeloupe, and in New Caledonia. We investigated the phenotype of atypical Parkinsonism in three of these foci and observed several similarities with dementia in most and amyotrophic lateral sclerosis in some. This disappearance of this disease in two places—Guam and New Guinea—suggested an environmental origin which has not been clarified before the disease ended. The exposure to annonaceae acetogenins and/or rotenone has been documented in four of these places, and experimental studies in animals demonstrated annonaceae acetogenins neurotoxicity, which is similar to rotenone neurotoxicity. Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. © 2006 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003421 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003421 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDD |texte= Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |