Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Identifieur interne : 002F33 ( Istex/Corpus ); précédent : 002F32; suivant : 002F34Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Auteurs : Dominique Caparros-Lefebvre ; John Steele ; Yaichiro Kotake ; Shigeru OhtaSource :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
English descriptors
Abstract
Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. It was first described on Guam, later in New Guinea and in the Kii peninsula, on Guadeloupe, and in New Caledonia. We investigated the phenotype of atypical Parkinsonism in three of these foci and observed several similarities with dementia in most and amyotrophic lateral sclerosis in some. This disappearance of this disease in two places—Guam and New Guinea—suggested an environmental origin which has not been clarified before the disease ended. The exposure to annonaceae acetogenins and/or rotenone has been documented in four of these places, and experimental studies in animals demonstrated annonaceae acetogenins neurotoxicity, which is similar to rotenone neurotoxicity. Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21024
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ISTEX:120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDDLe document en format XML
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Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>atypical Parkinsonism</topic><topic>Guam</topic><topic>Guadeloupe</topic><topic>annonaceae acetogenins</topic><topic>rotenone</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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