Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Identifieur interne : 001E81 ( Istex/Checkpoint ); précédent : 001E80; suivant : 001E82Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Auteurs : Dominique Caparros-Lefebvre [France] ; John Steele [États-Unis] ; Yaichiro Kotake [Japon] ; Shigeru Ohta [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Descripteurs français
- Wicri :
- topic : Guadeloupe, Guam.
English descriptors
Abstract
Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. It was first described on Guam, later in New Guinea and in the Kii peninsula, on Guadeloupe, and in New Caledonia. We investigated the phenotype of atypical Parkinsonism in three of these foci and observed several similarities with dementia in most and amyotrophic lateral sclerosis in some. This disappearance of this disease in two places—Guam and New Guinea—suggested an environmental origin which has not been clarified before the disease ended. The exposure to annonaceae acetogenins and/or rotenone has been documented in four of these places, and experimental studies in animals demonstrated annonaceae acetogenins neurotoxicity, which is similar to rotenone neurotoxicity. Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21024
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1769">1769</biblScope><biblScope unit="page" to="1771">1771</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">120038CF0BBA03A07A0CDAFF4AEFC81FB29C9FDD</idno><idno type="DOI">10.1002/mds.21024</idno><idno type="ArticleID">MDS21024</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Guadeloupe</term><term>Guam</term><term>annonaceae acetogenins</term><term>atypical Parkinsonism</term><term>rotenone</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Guadeloupe</term><term>Guam</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. 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