MovDisordV3, Main, Curation, bibRecord, 003046

Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome

Identifieur interne : 003046 ( Main/Curation ); précédent : 003045; suivant : 003047

Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome

Auteurs : Michael Behen [États-Unis] ; Harry T. Chugani [États-Unis] ; Csaba Juhász [États-Unis] ; Emily Helder [États-Unis] ; Albert Ho [États-Unis] ; Mohsin Maqbool [États-Unis] ; Robert D. Rothermel [États-Unis] ; Jacquie Perry [États-Unis] ; Otto Muzik [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-11-15.

RBID : ISTEX:9F8EC57DF5DCE1029BFAD24701E461DFCB687450

Descripteurs français

Pascal (Inist)
- Encéphale, Métabolisme, Pathologie du système nerveux, Positon, Syndrome de Gilles de la Tourette, Sérotonine, Tomographie par émission de positons, Tomoscintigraphie, Tryptophane.

English descriptors

KwdEn :
- Adolescent, Brain (metabolism), Brain (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cerebral Cortex (metabolism), Cerebral Cortex (radionuclide imaging), Child, Child, Preschool, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Emission tomography, Encephalon, Female, Gilles de la Tourette syndrome, Humans, Male, Metabolism, Nervous system diseases, Positron, Positron emission tomography, Positron-Emission Tomography, Serotonin, Serotonin (metabolism), Severity of Illness Index, Thalamus (metabolism), Thalamus (radionuclide imaging), Tourette Syndrome (metabolism), Tourette Syndrome (radionuclide imaging), Tourette syndrome, Tryptophan, Tryptophan (analogs & derivatives), Tryptophan (metabolism), Tryptophan (pharmacokinetics), fronto‐striatal‐thalamic circuit, neuroimaging, neuropsychology, positron emission tomography (PET), serotonin.
MESH :
- chemical , analogs & derivatives : Tryptophan.
- chemical , diagnostic use : Carbon Radioisotopes.
- metabolism : Brain, Cerebral Cortex, Corpus Striatum, Serotonin, Thalamus, Tourette Syndrome, Tryptophan.
- chemical , pharmacokinetics : Tryptophan.
- radionuclide imaging : Brain, Cerebral Cortex, Corpus Striatum, Thalamus, Tourette Syndrome.
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Positron-Emission Tomography, Severity of Illness Index.

Abstract

Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal‐thalamo‐cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used α‐[11C]methyl‐L‐tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto‐striatal‐thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/9F8EC57DF5DCE1029BFAD24701E461DFCB687450/fulltext/pdf

DOI: 10.1002/mds.21712

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<term>Carbon Radioisotopes (diagnostic use)</term>
<term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
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<term>Severity of Illness Index</term>
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<term>Thalamus (radionuclide imaging)</term>
<term>Tourette Syndrome (metabolism)</term>
<term>Tourette Syndrome (radionuclide imaging)</term>
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<front><div type="abstract" xml:lang="en">Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal‐thalamo‐cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used α‐[11C]methyl‐L‐tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto‐striatal‐thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS. © 2007 Movement Disorder Society</div>
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<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine</s1>
<s2>Detroit, Michigan</s2>
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<author><name sortKey="Juhasz, Csaba" sort="Juhasz, Csaba" uniqKey="Juhasz C" first="Csaba" last="Juhasz">Csaba Juhasz</name>
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<placeName><region type="state">Michigan</region>
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<s2>Detroit, Michigan</s2>
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<sZ>2 aut.</sZ>
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<s2>Detroit, Michigan</s2>
<s3>USA</s3>
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<s2>Detroit, Michigan</s2>
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<author><name sortKey="Muzik, Otto" sort="Muzik, Otto" uniqKey="Muzik O" first="Otto" last="Muzik">Otto Muzik</name>
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<s2>Detroit, Michigan</s2>
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<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine</s1>
<s2>Detroit, Michigan</s2>
<s3>USA</s3>
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<placeName><region type="state">Michigan</region>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
<term>Encephalon</term>
<term>Gilles de la Tourette syndrome</term>
<term>Metabolism</term>
<term>Nervous system diseases</term>
<term>Positron</term>
<term>Positron emission tomography</term>
<term>Serotonin</term>
<term>Tryptophan</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Syndrome de Gilles de la Tourette</term>
<term>Encéphale</term>
<term>Tryptophane</term>
<term>Métabolisme</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
<term>Positon</term>
<term>Sérotonine</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used -α[<sup>11</sup>
C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.</div>
</front>
</TEI>
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<author><name sortKey="Chugani, Harry T" sort="Chugani, Harry T" uniqKey="Chugani H" first="Harry T." last="Chugani">Harry T. Chugani</name>
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<author><name sortKey="Juhasz, Csaba" sort="Juhasz, Csaba" uniqKey="Juhasz C" first="Csaba" last="Juhász">Csaba Juhász</name>
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<author><name sortKey="Helder, Emily" sort="Helder, Emily" uniqKey="Helder E" first="Emily" last="Helder">Emily Helder</name>
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<placeName><region type="state">Michigan</region>
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<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
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</author>
<author><name sortKey="Juhasz, Csaba" sort="Juhasz, Csaba" uniqKey="Juhasz C" first="Csaba" last="Juhász">Csaba Juhász</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Helder, Emily" sort="Helder, Emily" uniqKey="Helder E" first="Emily" last="Helder">Emily Helder</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ho, Albert" sort="Ho, Albert" uniqKey="Ho A" first="Albert" last="Ho">Albert Ho</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maqbool, Mohsin" sort="Maqbool, Mohsin" uniqKey="Maqbool M" first="Mohsin" last="Maqbool">Mohsin Maqbool</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rothermel, Robert D" sort="Rothermel, Robert D" uniqKey="Rothermel R" first="Robert D." last="Rothermel">Robert D. Rothermel</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Perry, Jacquie" sort="Perry, Jacquie" uniqKey="Perry J" first="Jacquie" last="Perry">Jacquie Perry</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Muzik, Otto" sort="Muzik, Otto" uniqKey="Muzik O" first="Otto" last="Muzik">Otto Muzik</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-11-15">2007-11-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2256">2256</biblScope>
<biblScope unit="page" to="2262">2262</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9F8EC57DF5DCE1029BFAD24701E461DFCB687450</idno>
<idno type="DOI">10.1002/mds.21712</idno>
<idno type="ArticleID">MDS21712</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Brain (metabolism)</term>
<term>Brain (radionuclide imaging)</term>
<term>Carbon Radioisotopes (diagnostic use)</term>
<term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Positron-Emission Tomography</term>
<term>Serotonin (metabolism)</term>
<term>Severity of Illness Index</term>
<term>Thalamus (metabolism)</term>
<term>Thalamus (radionuclide imaging)</term>
<term>Tourette Syndrome (metabolism)</term>
<term>Tourette Syndrome (radionuclide imaging)</term>
<term>Tourette syndrome</term>
<term>Tryptophan (analogs & derivatives)</term>
<term>Tryptophan (metabolism)</term>
<term>Tryptophan (pharmacokinetics)</term>
<term>fronto‐striatal‐thalamic circuit</term>
<term>neuroimaging</term>
<term>neuropsychology</term>
<term>positron emission tomography (PET)</term>
<term>serotonin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tryptophan</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Cerebral Cortex</term>
<term>Corpus Striatum</term>
<term>Serotonin</term>
<term>Thalamus</term>
<term>Tourette Syndrome</term>
<term>Tryptophan</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Tryptophan</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term>
<term>Cerebral Cortex</term>
<term>Corpus Striatum</term>
<term>Thalamus</term>
<term>Tourette Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Positron-Emission Tomography</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal‐thalamo‐cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used α‐[11C]methyl‐L‐tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto‐striatal‐thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS. © 2007 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome

Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome

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