Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Identifieur interne : 002559 ( PubMed/Corpus ); précédent : 002558; suivant : 002560Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Auteurs : Michael Behen ; Harry T. Chugani ; Csaba Juhász ; Emily Helder ; Albert Ho ; Mohsin Maqbool ; Robert D. Rothermel ; Jacquie Perry ; Otto MuzikSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adolescent, Brain (metabolism), Brain (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cerebral Cortex (metabolism), Cerebral Cortex (radionuclide imaging), Child, Child, Preschool, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Female, Humans, Male, Positron-Emission Tomography, Serotonin (metabolism), Severity of Illness Index, Thalamus (metabolism), Thalamus (radionuclide imaging), Tourette Syndrome (metabolism), Tourette Syndrome (radionuclide imaging), Tryptophan (analogs & derivatives), Tryptophan (metabolism), Tryptophan (pharmacokinetics).
- MESH :
- chemical , analogs & derivatives : Tryptophan.
- chemical , diagnostic use : Carbon Radioisotopes.
- metabolism : Brain, Cerebral Cortex, Corpus Striatum, Serotonin, Thalamus, Tourette Syndrome, Tryptophan.
- chemical , pharmacokinetics : Tryptophan.
- radionuclide imaging : Brain, Cerebral Cortex, Corpus Striatum, Thalamus, Tourette Syndrome.
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Positron-Emission Tomography, Severity of Illness Index.
Abstract
Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used alpha-[(11)C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.
DOI: 10.1002/mds.21712
PubMed: 17708557
Links to Exploration step
pubmed:17708557Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.</title><author><name sortKey="Behen, Michael" sort="Behen, Michael" uniqKey="Behen M" first="Michael" last="Behen">Michael Behen</name><affiliation><nlm:affiliation>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chugani, Harry T" sort="Chugani, Harry T" uniqKey="Chugani H" first="Harry T" last="Chugani">Harry T. Chugani</name></author><author><name sortKey="Juhasz, Csaba" sort="Juhasz, Csaba" uniqKey="Juhasz C" first="Csaba" last="Juhász">Csaba Juhász</name></author><author><name sortKey="Helder, Emily" sort="Helder, Emily" uniqKey="Helder E" first="Emily" last="Helder">Emily Helder</name></author><author><name sortKey="Ho, Albert" sort="Ho, Albert" uniqKey="Ho A" first="Albert" last="Ho">Albert Ho</name></author><author><name sortKey="Maqbool, Mohsin" sort="Maqbool, Mohsin" uniqKey="Maqbool M" first="Mohsin" last="Maqbool">Mohsin Maqbool</name></author><author><name sortKey="Rothermel, Robert D" sort="Rothermel, Robert D" uniqKey="Rothermel R" first="Robert D" last="Rothermel">Robert D. Rothermel</name></author><author><name sortKey="Perry, Jacquie" sort="Perry, Jacquie" uniqKey="Perry J" first="Jacquie" last="Perry">Jacquie Perry</name></author><author><name sortKey="Muzik, Otto" sort="Muzik, Otto" uniqKey="Muzik O" first="Otto" last="Muzik">Otto Muzik</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21712</idno><idno type="RBID">pubmed:17708557</idno><idno type="pmid">17708557</idno><idno type="wicri:Area/PubMed/Corpus">002559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.</title><author><name sortKey="Behen, Michael" sort="Behen, Michael" uniqKey="Behen M" first="Michael" last="Behen">Michael Behen</name><affiliation><nlm:affiliation>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chugani, Harry T" sort="Chugani, Harry T" uniqKey="Chugani H" first="Harry T" last="Chugani">Harry T. Chugani</name></author><author><name sortKey="Juhasz, Csaba" sort="Juhasz, Csaba" uniqKey="Juhasz C" first="Csaba" last="Juhász">Csaba Juhász</name></author><author><name sortKey="Helder, Emily" sort="Helder, Emily" uniqKey="Helder E" first="Emily" last="Helder">Emily Helder</name></author><author><name sortKey="Ho, Albert" sort="Ho, Albert" uniqKey="Ho A" first="Albert" last="Ho">Albert Ho</name></author><author><name sortKey="Maqbool, Mohsin" sort="Maqbool, Mohsin" uniqKey="Maqbool M" first="Mohsin" last="Maqbool">Mohsin Maqbool</name></author><author><name sortKey="Rothermel, Robert D" sort="Rothermel, Robert D" uniqKey="Rothermel R" first="Robert D" last="Rothermel">Robert D. Rothermel</name></author><author><name sortKey="Perry, Jacquie" sort="Perry, Jacquie" uniqKey="Perry J" first="Jacquie" last="Perry">Jacquie Perry</name></author><author><name sortKey="Muzik, Otto" sort="Muzik, Otto" uniqKey="Muzik O" first="Otto" last="Muzik">Otto Muzik</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Brain (metabolism)</term><term>Brain (radionuclide imaging)</term><term>Carbon Radioisotopes (diagnostic use)</term><term>Cerebral Cortex (metabolism)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Child</term><term>Child, Preschool</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Female</term><term>Humans</term><term>Male</term><term>Positron-Emission Tomography</term><term>Serotonin (metabolism)</term><term>Severity of Illness Index</term><term>Thalamus (metabolism)</term><term>Thalamus (radionuclide imaging)</term><term>Tourette Syndrome (metabolism)</term><term>Tourette Syndrome (radionuclide imaging)</term><term>Tryptophan (analogs & derivatives)</term><term>Tryptophan (metabolism)</term><term>Tryptophan (pharmacokinetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tryptophan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Cerebral Cortex</term><term>Corpus Striatum</term><term>Serotonin</term><term>Thalamus</term><term>Tourette Syndrome</term><term>Tryptophan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Tryptophan</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Cerebral Cortex</term><term>Corpus Striatum</term><term>Thalamus</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Positron-Emission Tomography</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used alpha-[(11)C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17708557</PMID><DateCreated><Year>2007</Year><Month>12</Month><Day>06</Day></DateCreated><DateCompleted><Year>2008</Year><Month>01</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>15</Issue><PubDate><Year>2007</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.</ArticleTitle><Pagination><MedlinePgn>2256-62</MedlinePgn></Pagination><Abstract><AbstractText>Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used alpha-[(11)C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.</AbstractText><CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Behen</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chugani</LastName><ForeName>Harry T</ForeName><Initials>HT</Initials></Author><Author ValidYN="Y"><LastName>Juhász</LastName><ForeName>Csaba</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Helder</LastName><ForeName>Emily</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Albert</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Maqbool</LastName><ForeName>Mohsin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rothermel</LastName><ForeName>Robert D</ForeName><Initials>RD</Initials></Author><Author ValidYN="Y"><LastName>Perry</LastName><ForeName>Jacquie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Muzik</LastName><ForeName>Otto</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>333DO1RDJY</RegistryNumber><NameOfSubstance UI="D012701">Serotonin</NameOfSubstance></Chemical><Chemical><RegistryNumber>7303-49-3</RegistryNumber><NameOfSubstance UI="C028129">tryptophan methyl ester</NameOfSubstance></Chemical><Chemical><RegistryNumber>8DUH1N11BX</RegistryNumber><NameOfSubstance UI="D014364">Tryptophan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002250">Carbon Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N" 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MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D049268">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012701">Serotonin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013788">Thalamus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014364">Tryptophan</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000031">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>2</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21712</ArticleId><ArticleId 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