MovDisordV3, PascalFrancis, Corpus, bibRecord, 001447

Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome

Identifieur interne : 001447 ( PascalFrancis/Corpus ); précédent : 001446; suivant : 001448

Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome

Auteurs : Michael Behen ; Harry T. Chugani ; Csaba Juhasz ; Emily Helder ; Albert Ho ; Mohsin Maqbool ; Robert D. Rothermel ; Jacquie Perry ; Otto Muzik

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0071414

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Syndrome de Gilles de la Tourette, Encéphale, Tryptophane, Métabolisme, Tomoscintigraphie, Tomographie par émission de positons, Positon, Sérotonine.

English descriptors

KwdEn :
- Emission tomography, Encephalon, Gilles de la Tourette syndrome, Metabolism, Nervous system diseases, Positron, Positron emission tomography, Serotonin, Tryptophan.

Abstract

Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used -α[¹¹C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 08-0071414 INIST
ET :	Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome
AU :	BEHEN (Michael); CHUGANI (Harry T.); JUHASZ (Csaba); HELDER (Emily); HO (Albert); MAQBOOL (Mohsin); ROTHERMEL (Robert D.); PERRY (Jacquie); MUZIK (Otto)
AF :	Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (2 aut., 9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2256-2262; Bibl. 44 ref.
LA :	Anglais
EA :	Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used -α[¹¹C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.
CC :	002B17; 002B17F; 002B17D
FD :	Pathologie du système nerveux; Syndrome de Gilles de la Tourette; Encéphale; Tryptophane; Métabolisme; Tomoscintigraphie; Tomographie par émission de positons; Positon; Sérotonine
FG :	Système nerveux central; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central; Neurotransmetteur
ED :	Nervous system diseases; Gilles de la Tourette syndrome; Encephalon; Tryptophan; Metabolism; Emission tomography; Positron emission tomography; Positron; Serotonin
EG :	Central nervous system; Cerebral disorder; Degenerative disease; Central nervous system disease; Neurotransmitter
SD :	Sistema nervioso patología; Gilles de la Tourette síndrome; Encéfalo; Triptófano; Metabolismo; Tomocentelleografía; Tomografía emisión positrones; Positrón; Serotonina
LO :	INIST-20953.354000162671070180
ID :	08-0071414

Links to Exploration step

Pascal:08-0071414

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome</title>
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<front><div type="abstract" xml:lang="en">Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used -α[<sup>11</sup>
C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.</div>
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<ET>Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome</ET>
<AU>BEHEN (Michael); CHUGANI (Harry T.); JUHASZ (Csaba); HELDER (Emily); HO (Albert); MAQBOOL (Mohsin); ROTHERMEL (Robert D.); PERRY (Jacquie); MUZIK (Otto)</AU>
<AF>Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (2 aut., 9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2256-2262; Bibl. 44 ref.</SO>
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<EA>Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blood, cerebrospinal fluid and brain tissue of TS patients, understanding of focal brain disturbances and their relationship to clinical phenotype remains poor. We used -α[<sup>11</sup>
C]methyl-L-tryptophan (AMT) positron emission tomography (PET) to assess global and focal brain abnormalities of tryptophan metabolism and their relationship to behavioral phenotype in 26 children with TS and nine controls. Group comparisons on regional cortical and subcortical AMT uptake revealed decreased AMT uptake in bilateral dorsolateral prefrontal cortical and bilaterally increased uptake in the thalamus (P = 0.001) in TS children. The ratio of AMT uptake in subcortical structures to dorsolateral prefrontal cortex was significantly increased bilaterally (P < 0.01) in TS patients also. Behaviorally defined subgroups within the TS sample revealed differences in the pattern of AMT uptake in the fronto-striatal-thalamic circuit. This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS.</EA>
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<FG>Système nerveux central; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central; Neurotransmetteur</FG>
<ED>Nervous system diseases; Gilles de la Tourette syndrome; Encephalon; Tryptophan; Metabolism; Emission tomography; Positron emission tomography; Positron; Serotonin</ED>
<EG>Central nervous system; Cerebral disorder; Degenerative disease; Central nervous system disease; Neurotransmitter</EG>
<SD>Sistema nervioso patología; Gilles de la Tourette síndrome; Encéfalo; Triptófano; Metabolismo; Tomocentelleografía; Tomografía emisión positrones; Positrón; Serotonina</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome

Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome

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