MovDisordV3, Main, Curation, bibRecord, 002E32

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Identifieur interne : 002E32 ( Main/Curation ); précédent : 002E31; suivant : 002E33

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Auteurs : Ettore Accolla [Italie] ; Elena Caputo [Italie] ; Filippo Cogiamanian [Italie] ; Filippo Tamma [Italie] ; Simona Mrakic-Sposta [Italie] ; Sara Marceglia [Italie] ; Marcello Egidi [Italie] ; Paolo Rampini [Italie] ; Marco Locatelli [Italie] ; Alberto Priori [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-06-15.

RBID : ISTEX:92FA111511E75DE30C564A4A7B8A6C4590EC57D1

Descripteurs français

Pascal (Inist)
- Homme, Noyau sousthalamique, Parkinson maladie, Sexe, Stimulation cérébrale profonde, Système nerveux pathologie, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Age of Onset, Brain (surgery), Deep Brain Stimulation (methods), Deep brain stimulation, Female, Human, Humans, Hypokinesia (diagnosis), Hypokinesia (epidemiology), Male, Middle Aged, Nervous system diseases, Neurosurgical Procedures, Parkinson Disease (epidemiology), Parkinson Disease (surgery), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Preoperative Care, Prevalence, Severity of Illness Index, Sex, Sex Factors, Subthalamic Nucleus (physiology), Subthalamic nucleus, Treatment, deep brain stimulation, gender, subthalamic nucleus.
MESH :
- diagnosis : Hypokinesia.
- epidemiology : Hypokinesia, Parkinson Disease.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- surgery : Brain, Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Age of Onset, Female, Humans, Male, Middle Aged, Neurosurgical Procedures, Preoperative Care, Prevalence, Severity of Illness Index, Sex Factors.

Abstract

We investigated gender‐differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty‐eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa‐induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender‐related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN‐DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN‐DBS treatment. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/92FA111511E75DE30C564A4A7B8A6C4590EC57D1/fulltext/pdf

DOI: 10.1002/mds.21520

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ISTEX:92FA111511E75DE30C564A4A7B8A6C4590EC57D1

Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated gender‐differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty‐eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa‐induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender‐related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN‐DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN‐DBS treatment. © 2007 Movement Disorder Society</div>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation</title>
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<author><name sortKey="Caputo, Elena" sort="Caputo, Elena" uniqKey="Caputo E" first="Elena" last="Caputo">Elena Caputo</name>
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<author><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name>
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<author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Sex</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Sexe</term>
<term>Homme</term>
<term>Traitement</term>
<term>Noyau sousthalamique</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
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<front><div type="abstract" xml:lang="en">We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.</div>
</front>
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<author><name sortKey="Cogiamanian, Filippo" sort="Cogiamanian, Filippo" uniqKey="Cogiamanian F" first="Filippo" last="Cogiamanian">Filippo Cogiamanian</name>
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<author><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name>
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<author><name sortKey="Caputo, Elena" sort="Caputo, Elena" uniqKey="Caputo E" first="Elena" last="Caputo">Elena Caputo</name>
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<wicri:regionArea>Dipartimento di Neurologia Clinica, Ospedale San Paolo, Milano</wicri:regionArea>
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<author><name sortKey="Cogiamanian, Filippo" sort="Cogiamanian, Filippo" uniqKey="Cogiamanian F" first="Filippo" last="Cogiamanian">Filippo Cogiamanian</name>
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<wicri:noRegion>Milano</wicri:noRegion>
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<author><name sortKey="Tamma, Filippo" sort="Tamma, Filippo" uniqKey="Tamma F" first="Filippo" last="Tamma">Filippo Tamma</name>
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<author><name sortKey="Mrakic Posta, Simona" sort="Mrakic Posta, Simona" uniqKey="Mrakic Posta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name>
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</author>
<author><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name>
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</author>
<author><name sortKey="Egidi, Marcello" sort="Egidi, Marcello" uniqKey="Egidi M" first="Marcello" last="Egidi">Marcello Egidi</name>
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</affiliation>
</author>
<author><name sortKey="Rampini, Paolo" sort="Rampini, Paolo" uniqKey="Rampini P" first="Paolo" last="Rampini">Paolo Rampini</name>
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</affiliation>
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</affiliation>
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<wicri:noRegion>Milano</wicri:noRegion>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
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<idno type="eISSN">1531-8257</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Brain (surgery)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Hypokinesia (diagnosis)</term>
<term>Hypokinesia (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurosurgical Procedures</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson's disease</term>
<term>Preoperative Care</term>
<term>Prevalence</term>
<term>Severity of Illness Index</term>
<term>Sex Factors</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>deep brain stimulation</term>
<term>gender</term>
<term>subthalamic nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypokinesia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurosurgical Procedures</term>
<term>Preoperative Care</term>
<term>Prevalence</term>
<term>Severity of Illness Index</term>
<term>Sex Factors</term>
</keywords>
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<langUsage><language ident="en">en</language>
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<front><div type="abstract" xml:lang="en">We investigated gender‐differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty‐eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa‐induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender‐related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN‐DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN‐DBS treatment. © 2007 Movement Disorder Society</div>
</front>
</TEI>
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Movement Disorders (revue)

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

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