Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation
Identifieur interne : 001678 ( Istex/Curation ); précédent : 001677; suivant : 001679Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation
Auteurs : Ettore Accolla [Italie] ; Elena Caputo [Italie] ; Filippo Cogiamanian [Italie] ; Filippo Tamma [Italie] ; Simona Mrakic-Sposta [Italie] ; Sara Marceglia [Italie] ; Marcello Egidi [Italie] ; Paolo Rampini [Italie] ; Marco Locatelli [Italie] ; Alberto Priori [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
English descriptors
Abstract
We investigated gender‐differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty‐eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa‐induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender‐related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN‐DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN‐DBS treatment. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21520
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Milano</wicri:regionArea></affiliation></author><author><name sortKey="Locatelli, Marco" sort="Locatelli, Marco" uniqKey="Locatelli M" first="Marco" last="Locatelli">Marco Locatelli</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale, Policlinico, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale, Policlinico, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale, Policlinico, Milano, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale, Policlinico, Milano</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-15">2007-06-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1150">1150</biblScope><biblScope unit="page" to="1156">1156</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">92FA111511E75DE30C564A4A7B8A6C4590EC57D1</idno><idno type="DOI">10.1002/mds.21520</idno><idno type="ArticleID">MDS21520</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>gender</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated gender‐differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty‐eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa‐induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender‐related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN‐DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN‐DBS treatment. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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