MovDisordV3, Main, Curation, bibRecord, 002957

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

Identifieur interne : 002957 ( Main/Curation ); précédent : 002956; suivant : 002958

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

Auteurs : Hiroshige Fujishiro [États-Unis] ; Roberta Frigerio [États-Unis] ; Melinda Burnett [États-Unis] ; Kevin J. Klos [États-Unis] ; Keith A. Josephs [États-Unis] ; Anthony Delledonne [États-Unis] ; Joseph E. Parisi [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Dennis W. Dickson [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-06-15.

RBID : ISTEX:B2D178713218F90FD26FD418975AA3283957D11C

Descripteurs français

Pascal (Inist)
- Enervation, Maladie de Parkinson, Pathologie du système nerveux, Stade clinique, Tyrosine 3-monooxygenase.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Brain (pathology), Clinical stage, Denervation, Disease Progression, Female, Heart (innervation), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (pathology), Lewy Bodies (pathology), Male, Nerve Degeneration (pathology), Nerve Fibers (pathology), Nervous system diseases, Neurites (pathology), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Parkinson disease, Parkinsons, Pericardium (innervation), Pericardium (pathology), Spinal Cord (pathology), Sympathetic Nervous System (pathology), Tyrosine 3-Monooxygenase (analysis), Tyrosine 3-monooxygenase, alpha-Synuclein (analysis), cardiac, presymptomatic, tyrosine hydroxylase, α‐synuclein.
MESH :
- chemical , analysis : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- diagnosis : Hypotension, Orthostatic, Parkinson Disease.
- innervation : Heart, Pericardium.
- pathology : Brain, Hypotension, Orthostatic, Lewy Bodies, Nerve Degeneration, Nerve Fibers, Neurites, Parkinson Disease, Pericardium, Spinal Cord, Sympathetic Nervous System.
- Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male.

Abstract

Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.

Url:

https://api.istex.fr/document/B2D178713218F90FD26FD418975AA3283957D11C/fulltext/pdf

DOI: 10.1002/mds.21989

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C16
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C16
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001514
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002241
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002241
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002397
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002120
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002120
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002120
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003536
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001222
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001A97
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001336
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003944

Links to Exploration step

ISTEX:B2D178713218F90FD26FD418975AA3283957D11C

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B2D178713218F90FD26FD418975AA3283957D11C</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21989</idno>
<idno type="url">https://api.istex.fr/document/B2D178713218F90FD26FD418975AA3283957D11C/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C16</idno>
<idno type="wicri:Area/Istex/Curation">000C16</idno>
<idno type="wicri:Area/Istex/Checkpoint">001514</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18442129</idno>
<idno type="wicri:Area/PubMed/Corpus">002241</idno>
<idno type="wicri:Area/PubMed/Curation">002241</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002397</idno>
<idno type="wicri:Area/Ncbi/Merge">002120</idno>
<idno type="wicri:Area/Ncbi/Curation">002120</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002120</idno>
<idno type="wicri:Area/Main/Merge">003536</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:08-0357224</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001222</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A97</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001336</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
<idno type="wicri:Area/Main/Merge">003944</idno>
<idno type="wicri:Area/Main/Curation">002957</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
<wicri:cityArea>Neurological Associates of Tulsa, Tulsa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-06-15">2008-06-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1085">1085</biblScope>
<biblScope unit="page" to="1092">1092</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B2D178713218F90FD26FD418975AA3283957D11C</idno>
<idno type="DOI">10.1002/mds.21989</idno>
<idno type="ArticleID">MDS21989</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain (pathology)</term>
<term>Clinical stage</term>
<term>Denervation</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Heart (innervation)</term>
<term>Humans</term>
<term>Hypotension, Orthostatic (diagnosis)</term>
<term>Hypotension, Orthostatic (pathology)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Nerve Degeneration (pathology)</term>
<term>Nerve Fibers (pathology)</term>
<term>Nervous system diseases</term>
<term>Neurites (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson disease</term>
<term>Parkinsons</term>
<term>Pericardium (innervation)</term>
<term>Pericardium (pathology)</term>
<term>Spinal Cord (pathology)</term>
<term>Sympathetic Nervous System (pathology)</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
<term>Tyrosine 3-monooxygenase</term>
<term>alpha-Synuclein (analysis)</term>
<term>cardiac</term>
<term>presymptomatic</term>
<term>tyrosine hydroxylase</term>
<term>α‐synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term>
<term>Pericardium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Hypotension, Orthostatic</term>
<term>Lewy Bodies</term>
<term>Nerve Degeneration</term>
<term>Nerve Fibers</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
<term>Pericardium</term>
<term>Spinal Cord</term>
<term>Sympathetic Nervous System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Enervation</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Stade clinique</term>
<term>Tyrosine 3-monooxygenase</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.</div>
</front>
</TEI>
<double idat="0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cardiac Sympathetic Denervation Correlates with Clinical and Pathologic Stages of Parkinson's Disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Neurological Associates of Tulsa</s1>
<s2>Tulsa, Oklahoma</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Laboratory Medicine and Pathology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0357224</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0357224 INIST</idno>
<idno type="RBID">Pascal:08-0357224</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001222</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A97</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001336</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
<idno type="wicri:Area/Main/Merge">003944</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cardiac Sympathetic Denervation Correlates with Clinical and Pathologic Stages of Parkinson's Disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Neurological Associates of Tulsa</s1>
<s2>Tulsa, Oklahoma</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Laboratory Medicine and Pathology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pathology (Neuropathology), Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neuroscience, Mayo Clinic</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical stage</term>
<term>Denervation</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Tyrosine 3-monooxygenase</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Enervation</term>
<term>Stade clinique</term>
<term>Tyrosine 3-monooxygenase</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH-immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH-immunoreactive fibers correlated with the PD stage (r = -0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = -0.61, P < 0.001), and disease duration (r = -0.63, P < 0.001). Immunohistochemistry for α-synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α-synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B2D178713218F90FD26FD418975AA3283957D11C</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21989</idno>
<idno type="url">https://api.istex.fr/document/B2D178713218F90FD26FD418975AA3283957D11C/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C16</idno>
<idno type="wicri:Area/Istex/Curation">000C16</idno>
<idno type="wicri:Area/Istex/Checkpoint">001514</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18442129</idno>
<idno type="wicri:Area/PubMed/Corpus">002241</idno>
<idno type="wicri:Area/PubMed/Curation">002241</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002397</idno>
<idno type="wicri:Area/Ncbi/Merge">002120</idno>
<idno type="wicri:Area/Ncbi/Curation">002120</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002120</idno>
<idno type="wicri:Area/Main/Merge">003536</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
<wicri:cityArea>Neurological Associates of Tulsa, Tulsa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-06-15">2008-06-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1085">1085</biblScope>
<biblScope unit="page" to="1092">1092</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B2D178713218F90FD26FD418975AA3283957D11C</idno>
<idno type="DOI">10.1002/mds.21989</idno>
<idno type="ArticleID">MDS21989</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain (pathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Heart (innervation)</term>
<term>Humans</term>
<term>Hypotension, Orthostatic (diagnosis)</term>
<term>Hypotension, Orthostatic (pathology)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Nerve Degeneration (pathology)</term>
<term>Nerve Fibers (pathology)</term>
<term>Neurites (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinsons</term>
<term>Pericardium (innervation)</term>
<term>Pericardium (pathology)</term>
<term>Spinal Cord (pathology)</term>
<term>Sympathetic Nervous System (pathology)</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
<term>alpha-Synuclein (analysis)</term>
<term>cardiac</term>
<term>presymptomatic</term>
<term>tyrosine hydroxylase</term>
<term>α‐synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term>
<term>Pericardium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Hypotension, Orthostatic</term>
<term>Lewy Bodies</term>
<term>Nerve Degeneration</term>
<term>Nerve Fibers</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
<term>Pericardium</term>
<term>Spinal Cord</term>
<term>Sympathetic Nervous System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002957 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002957 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:B2D178713218F90FD26FD418975AA3283957D11C
   |texte=   Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri