Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.
Identifieur interne : 002120 ( Ncbi/Curation ); précédent : 002119; suivant : 002121Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.
Auteurs : Hiroshige Fujishiro [États-Unis] ; Roberta Frigerio ; Melinda Burnett ; Kevin J. Klos ; Keith A. Josephs ; Anthony Delledonne ; Joseph E. Parisi ; J Eric Ahlskog ; Dennis W. DicksonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain (pathology), Disease Progression, Female, Heart (innervation), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (pathology), Lewy Bodies (pathology), Male, Nerve Degeneration (pathology), Nerve Fibers (pathology), Neurites (pathology), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Pericardium (innervation), Pericardium (pathology), Spinal Cord (pathology), Sympathetic Nervous System (pathology), Tyrosine 3-Monooxygenase (analysis), alpha-Synuclein (analysis).
- MESH :
- chemical , analysis : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- diagnosis : Hypotension, Orthostatic, Parkinson Disease.
- innervation : Heart, Pericardium.
- pathology : Brain, Hypotension, Orthostatic, Lewy Bodies, Nerve Degeneration, Nerve Fibers, Neurites, Parkinson Disease, Pericardium, Spinal Cord, Sympathetic Nervous System.
- Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male.
Abstract
Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH-immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH-immunoreactive fibers correlated with the PD stage (r = -0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = -0.61, P < 0.001), and disease duration (r = -0.63, P < 0.001). Immunohistochemistry for alpha-synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of alpha-synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and alpha-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity.
DOI: 10.1002/mds.21989
PubMed: 18442129
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Klos</name></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name></author><author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name></author><author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21989</idno><idno type="RBID">pubmed:18442129</idno><idno type="pmid">18442129</idno><idno type="wicri:Area/PubMed/Corpus">002241</idno><idno type="wicri:Area/PubMed/Curation">002241</idno><idno type="wicri:Area/PubMed/Checkpoint">002397</idno><idno type="wicri:Area/Ncbi/Merge">002120</idno><idno type="wicri:Area/Ncbi/Curation">002120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.</title><author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name></author><author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name></author><author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J" last="Klos">Kevin J. Klos</name></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name></author><author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name></author><author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain (pathology)</term><term>Disease Progression</term><term>Female</term><term>Heart (innervation)</term><term>Humans</term><term>Hypotension, Orthostatic (diagnosis)</term><term>Hypotension, Orthostatic (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Nerve Degeneration (pathology)</term><term>Nerve Fibers (pathology)</term><term>Neurites (pathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (pathology)</term><term>Pericardium (innervation)</term><term>Pericardium (pathology)</term><term>Spinal Cord (pathology)</term><term>Sympathetic Nervous System (pathology)</term><term>Tyrosine 3-Monooxygenase (analysis)</term><term>alpha-Synuclein (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term><term>Pericardium</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Hypotension, Orthostatic</term><term>Lewy Bodies</term><term>Nerve Degeneration</term><term>Nerve Fibers</term><term>Neurites</term><term>Parkinson Disease</term><term>Pericardium</term><term>Spinal Cord</term><term>Sympathetic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH-immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH-immunoreactive fibers correlated with the PD stage (r = -0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = -0.61, P < 0.001), and disease duration (r = -0.63, P < 0.001). Immunohistochemistry for alpha-synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of alpha-synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and alpha-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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