Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
Identifieur interne : 003536 ( Main/Merge ); précédent : 003535; suivant : 003537Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
Auteurs : Hiroshige Fujishiro [États-Unis] ; Roberta Frigerio [États-Unis] ; Melinda Burnett [États-Unis] ; Kevin J. Klos [États-Unis] ; Keith A. Josephs [États-Unis] ; Anthony Delledonne [États-Unis] ; Joseph E. Parisi [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Dennis W. Dickson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-06-15.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain (pathology), Disease Progression, Female, Heart (innervation), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (pathology), Lewy Bodies (pathology), Male, Nerve Degeneration (pathology), Nerve Fibers (pathology), Neurites (pathology), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Parkinsons, Pericardium (innervation), Pericardium (pathology), Spinal Cord (pathology), Sympathetic Nervous System (pathology), Tyrosine 3-Monooxygenase (analysis), alpha-Synuclein (analysis), cardiac, presymptomatic, tyrosine hydroxylase, α‐synuclein.
- MESH :
- chemical , analysis : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- diagnosis : Hypotension, Orthostatic, Parkinson Disease.
- innervation : Heart, Pericardium.
- pathology : Brain, Hypotension, Orthostatic, Lewy Bodies, Nerve Degeneration, Nerve Fibers, Neurites, Parkinson Disease, Pericardium, Spinal Cord, Sympathetic Nervous System.
- Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male.
Abstract
Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.
Url:
DOI: 10.1002/mds.21989
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C16
- to stream Istex, to step Curation: 000C16
- to stream Istex, to step Checkpoint: 001514
- to stream PubMed, to step Corpus: 002241
- to stream PubMed, to step Curation: 002241
- to stream PubMed, to step Checkpoint: 002397
- to stream Ncbi, to step Merge: 002120
- to stream Ncbi, to step Curation: 002120
- to stream Ncbi, to step Checkpoint: 002120
Links to Exploration step
ISTEX:B2D178713218F90FD26FD418975AA3283957D11CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B2D178713218F90FD26FD418975AA3283957D11C</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21989</idno>
<idno type="url">https://api.istex.fr/document/B2D178713218F90FD26FD418975AA3283957D11C/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C16</idno>
<idno type="wicri:Area/Istex/Curation">000C16</idno>
<idno type="wicri:Area/Istex/Checkpoint">001514</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18442129</idno>
<idno type="wicri:Area/PubMed/Corpus">002241</idno>
<idno type="wicri:Area/PubMed/Curation">002241</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002397</idno>
<idno type="wicri:Area/Ncbi/Merge">002120</idno>
<idno type="wicri:Area/Ncbi/Curation">002120</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002120</idno>
<idno type="wicri:Area/Main/Merge">003536</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
<wicri:cityArea>Neurological Associates of Tulsa, Tulsa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-06-15">2008-06-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1085">1085</biblScope>
<biblScope unit="page" to="1092">1092</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B2D178713218F90FD26FD418975AA3283957D11C</idno>
<idno type="DOI">10.1002/mds.21989</idno>
<idno type="ArticleID">MDS21989</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain (pathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Heart (innervation)</term>
<term>Humans</term>
<term>Hypotension, Orthostatic (diagnosis)</term>
<term>Hypotension, Orthostatic (pathology)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Nerve Degeneration (pathology)</term>
<term>Nerve Fibers (pathology)</term>
<term>Neurites (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinsons</term>
<term>Pericardium (innervation)</term>
<term>Pericardium (pathology)</term>
<term>Spinal Cord (pathology)</term>
<term>Sympathetic Nervous System (pathology)</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
<term>alpha-Synuclein (analysis)</term>
<term>cardiac</term>
<term>presymptomatic</term>
<term>tyrosine hydroxylase</term>
<term>α‐synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term>
<term>Pericardium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Hypotension, Orthostatic</term>
<term>Lewy Bodies</term>
<term>Nerve Degeneration</term>
<term>Nerve Fibers</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
<term>Pericardium</term>
<term>Spinal Cord</term>
<term>Sympathetic Nervous System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.</div>
</front>
</TEI>
<double doi="10.1002/mds.21989"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B2D178713218F90FD26FD418975AA3283957D11C</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21989</idno>
<idno type="url">https://api.istex.fr/document/B2D178713218F90FD26FD418975AA3283957D11C/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C16</idno>
<idno type="wicri:Area/Istex/Curation">000C16</idno>
<idno type="wicri:Area/Istex/Checkpoint">001514</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Fujishiro H:cardiac:sympathetic:denervation</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oklahoma</region>
</placeName>
<wicri:cityArea>Neurological Associates of Tulsa, Tulsa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-06-15">2008-06-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1085">1085</biblScope>
<biblScope unit="page" to="1092">1092</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B2D178713218F90FD26FD418975AA3283957D11C</idno>
<idno type="DOI">10.1002/mds.21989</idno>
<idno type="ArticleID">MDS21989</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinsons</term>
<term>cardiac</term>
<term>presymptomatic</term>
<term>tyrosine hydroxylase</term>
<term>α‐synuclein</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J" last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.21989</idno>
<idno type="RBID">pubmed:18442129</idno>
<idno type="pmid">18442129</idno>
<idno type="wicri:Area/PubMed/Corpus">002241</idno>
<idno type="wicri:Area/PubMed/Curation">002241</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002397</idno>
<idno type="wicri:Area/Ncbi/Merge">002120</idno>
<idno type="wicri:Area/Ncbi/Curation">002120</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002120</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.</title>
<author><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
</author>
<author><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name>
</author>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J" last="Klos">Kevin J. Klos</name>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain (pathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Heart (innervation)</term>
<term>Humans</term>
<term>Hypotension, Orthostatic (diagnosis)</term>
<term>Hypotension, Orthostatic (pathology)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Nerve Degeneration (pathology)</term>
<term>Nerve Fibers (pathology)</term>
<term>Neurites (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Pericardium (innervation)</term>
<term>Pericardium (pathology)</term>
<term>Spinal Cord (pathology)</term>
<term>Sympathetic Nervous System (pathology)</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
<term>alpha-Synuclein (analysis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term>
<term>Pericardium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Hypotension, Orthostatic</term>
<term>Lewy Bodies</term>
<term>Nerve Degeneration</term>
<term>Nerve Fibers</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
<term>Pericardium</term>
<term>Spinal Cord</term>
<term>Sympathetic Nervous System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH-immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH-immunoreactive fibers correlated with the PD stage (r = -0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = -0.61, P < 0.001), and disease duration (r = -0.63, P < 0.001). Immunohistochemistry for alpha-synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of alpha-synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and alpha-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003536 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003536 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:B2D178713218F90FD26FD418975AA3283957D11C |texte= Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |