MovDisordV3, Main, Curation, bibRecord, 002412

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

Identifieur interne : 002412 ( Main/Curation ); précédent : 002411; suivant : 002413

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

Auteurs : Masato Kanazawa [Japon] ; Takayoshi Shimohata [Japon] ; Yasuko Toyoshima [Japon] ; Mari Tada [Japon] ; Akiyoshi Kakita [Japon] ; Takashi Morita [Japon] ; Tetsutaro Ozawa [Japon] ; Hitoshi Takahashi [Japon] ; Masatoyo Nishizawa [Japon]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-07-15.

RBID : ISTEX:794DDA51BBCBE22D672130D09EA1D289879D5C07

Descripteurs français

Pascal (Inist)
- Ataxie spinocérébelleuse, Cervelet, Maladie de Parkinson, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Cell Death (physiology), Cerebellum, Cerebellum (metabolism), Cerebellum (pathology), Cerebellum (physiopathology), Female, Humans, Longitudinal Studies, Male, Nerve Tissue Proteins (metabolism), Nervous system diseases, Neurons (metabolism), Neurons (pathology), Neurons (ultrastructure), Parkinson disease, Parkinson's disease, Retrospective Studies, Silver Staining (methods), Spinocerebellar ataxia, Supranuclear Palsy, Progressive (classification), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), parkinsonian disorders, progressive supranuclear palsy, spinocerebellar ataxias, tau Proteins (metabolism).
MESH :
- chemical , metabolism : Nerve Tissue Proteins, tau Proteins.
- classification : Supranuclear Palsy, Progressive.
- metabolism : Cerebellum, Neurons.
- methods : Silver Staining.
- pathology : Cerebellum, Neurons, Supranuclear Palsy, Progressive.
- physiology : Cell Death.
- physiopathology : Cerebellum, Supranuclear Palsy, Progressive.
- ultrastructure : Neurons.
- Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Retrospective Studies.

Abstract

The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP‐Parkinsonism (PSP‐P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP‐P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau‐positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/794DDA51BBCBE22D672130D09EA1D289879D5C07/fulltext/pdf

DOI: 10.1002/mds.22583

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ISTEX:794DDA51BBCBE22D672130D09EA1D289879D5C07

Le document en format XML

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<term>Cerebellum (pathology)</term>
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<term>Humans</term>
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<term>Nervous system diseases</term>
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<term>Supranuclear Palsy, Progressive (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP‐Parkinsonism (PSP‐P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP‐P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau‐positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia. © 2009 Movement Disorder Society</div>
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<author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name>
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<author><name sortKey="Morita, Takashi" sort="Morita, Takashi" uniqKey="Morita T" first="Takashi" last="Morita">Takashi Morita</name>
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<author><name sortKey="Ozawa, Tetsutaro" sort="Ozawa, Tetsutaro" uniqKey="Ozawa T" first="Tetsutaro" last="Ozawa">Tetsutaro Ozawa</name>
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<author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name>
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<author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name>
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<author><name sortKey="Shimohata, Takayoshi" sort="Shimohata, Takayoshi" uniqKey="Shimohata T" first="Takayoshi" last="Shimohata">Takayoshi Shimohata</name>
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<author><name sortKey="Toyoshima, Yasuko" sort="Toyoshima, Yasuko" uniqKey="Toyoshima Y" first="Yasuko" last="Toyoshima">Yasuko Toyoshima</name>
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<author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name>
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<front><div type="abstract" xml:lang="en">The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.</div>
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<front><div type="abstract" xml:lang="en">The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP‐Parkinsonism (PSP‐P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP‐P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau‐positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia. © 2009 Movement Disorder Society</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

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