Cerebrospinal tau, phospho‐tau, and beta‐amyloid and neuropsychological functions in Parkinson's disease
Identifieur interne : 002411 ( Main/Curation ); précédent : 002410; suivant : 002412Cerebrospinal tau, phospho‐tau, and beta‐amyloid and neuropsychological functions in Parkinson's disease
Auteurs : Yaroslau Compta [Espagne] ; María J. Martí [Espagne] ; Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junqué [Espagne] ; Francesc Valldeoriola [Espagne] ; Esteban Mu Oz [Espagne] ; Mario Ezquerra [Espagne] ; Jose Ríos [Espagne] ; Eduardo Tolosa [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Amyloid, Amyloid beta-Peptides (cerebrospinal fluid), Case-Control Studies, Cerebrospinal fluid, Dementia, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Mental Processes (physiology), Mental Status Schedule, Middle Aged, Multivariate Analysis, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Phosphorylation (physiology), Retrospective Studies, Statistics as Topic, beta‐amyloid, cerebrospinal fluid, dementia, neuropsychological function, tau, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Amyloid beta-Peptides, tau Proteins.
- cerebrospinal fluid : Parkinson Disease.
- physiology : Mental Processes, Phosphorylation.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Mental Status Schedule, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Retrospective Studies, Statistics as Topic.
Abstract
Alzheimer's disease (AD)‐pathology may play a role in Parkinson's disease (PD)‐related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho‐tau, and beta‐amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho‐tau, and beta‐amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto‐subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers levels were compared between groups, and compared and correlated with neuropsychological measures in PDND and PDD separately and as a continuum (PD). CSF tau and phospho‐tau were higher in PDD than in PDND and controls (P < 0.05). CSF beta‐amyloid ranged from high (controls) to intermediate (PDND) and low (PDD) levels (P < 0.001). In all PD and PDD patients, high CSF tau and phospho‐tau were associated with impaired memory and naming. In PDND, CSF beta‐amyloid was related with phonetic fluency. These findings suggest underlying AD‐pathology in PDD in association with cortical cognitive dysfunction, and that low CSF beta‐amyloid in PDND patients with impaired phonetic fluency can constitute an early marker of cognitive dysfunction. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22594
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<term>Amyloid</term>
<term>Amyloid beta-Peptides (cerebrospinal fluid)</term>
<term>Case-Control Studies</term>
<term>Cerebrospinal fluid</term>
<term>Dementia</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Processes (physiology)</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Phosphorylation (physiology)</term>
<term>Retrospective Studies</term>
<term>Statistics as Topic</term>
<term>beta‐amyloid</term>
<term>cerebrospinal fluid</term>
<term>dementia</term>
<term>neuropsychological function</term>
<term>tau</term>
<term>tau Proteins (cerebrospinal fluid)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>tau Proteins</term>
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<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Mental Processes</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
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<term>Enzyme-Linked Immunosorbent Assay</term>
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<term>Male</term>
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<term>Middle Aged</term>
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<term>Neuropsychological Tests</term>
<term>Retrospective Studies</term>
<term>Statistics as Topic</term>
</keywords>
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<term>Démence</term>
<term>Liquide céphalorachidien</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD)‐pathology may play a role in Parkinson's disease (PD)‐related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho‐tau, and beta‐amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho‐tau, and beta‐amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto‐subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers levels were compared between groups, and compared and correlated with neuropsychological measures in PDND and PDD separately and as a continuum (PD). CSF tau and phospho‐tau were higher in PDD than in PDND and controls (P < 0.05). CSF beta‐amyloid ranged from high (controls) to intermediate (PDND) and low (PDD) levels (P < 0.001). In all PD and PDD patients, high CSF tau and phospho‐tau were associated with impaired memory and naming. In PDND, CSF beta‐amyloid was related with phonetic fluency. These findings suggest underlying AD‐pathology in PDD in association with cortical cognitive dysfunction, and that low CSF beta‐amyloid in PDND patients with impaired phonetic fluency can constitute an early marker of cognitive dysfunction. © 2009 Movement Disorder Society</div>
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<author><name sortKey="Rios, Jose" sort="Rios, Jose" uniqKey="Rios J" first="Jose" last="Rios">Jose Rios</name>
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<sZ>8 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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<sZ>1 aut.</sZ>
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</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0036259</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 10-0036259 INIST</idno>
<idno type="RBID">Pascal:10-0036259</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000D18</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002001</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000F55</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Compta Y:cerebrospinal:tau:phospho</idno>
<idno type="wicri:Area/Main/Merge">003052</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cerebrospinal Tau, Phospho-Tau, and Beta-Amyloid and Neuropsychological Functions in Parkinson's Disease</title>
<author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name>
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<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name>
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<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry and Clinical Psychobiology IDIBAPS, CIBERNED, Faculty of Medicine, University of Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry and Clinical Psychobiology IDIBAPS, CIBERNED, Faculty of Medicine, University of Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic</s1>
<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munoz, Esteban" sort="Munoz, Esteban" uniqKey="Munoz E" first="Esteban" last="Munoz">Esteban Munoz</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic</s1>
<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ezquerra, Mario" sort="Ezquerra, Mario" uniqKey="Ezquerra M" first="Mario" last="Ezquerra">Mario Ezquerra</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic</s1>
<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rios, Jose" sort="Rios, Jose" uniqKey="Rios J" first="Jose" last="Rios">Jose Rios</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Statistics and Methodologic Support Unit, Unitat d'Avaluació, Suport i Prevenció (UASP), Hospital Clínic, IDIBAPS</s1>
<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic</s1>
<s2>Barcelona, Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Barcelona, Catalonia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyloid</term>
<term>Cerebrospinal fluid</term>
<term>Dementia</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Démence</term>
<term>Pathologie du système nerveux</term>
<term>Amyloïde</term>
<term>Liquide céphalorachidien</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD)-pathology may play a role in Parkinson's disease (PD)-related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho-tau, and beta-amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho-tau, and beta-amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto-subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers levels were compared between groups, and compared and correlated with neuropsychological measures in PDND and PDD separately and as a continuum (PD). CSF tau and phospho-tau were higher in PDD than in PDND and controls (P < 0.05). CSF beta-amyloid ranged from high (controls) to intermediate (PDND) and low (PDD) levels (P < 0.001). In all PD and PDD patients, high CSF tau and phospho-tau were associated with impaired memory and naming. In PDND, CSF beta-amyloid was related with phonetic fluency. These findings suggest underlying AD-pathology in PDD in association with cortical cognitive dysfunction, and that low CSF beta-amyloid in PDND patients with impaired phonetic fluency can constitute an early marker of cognitive dysfunction.</div>
</front>
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<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebrospinal tau, phospho‐tau, and beta‐amyloid and neuropsychological functions in Parkinson's disease</title>
<author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name>
</author>
<author><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="María J." last="Martí">María J. Martí</name>
</author>
<author><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
</author>
<author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
</author>
<author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
</author>
<author><name sortKey="Mu Oz, Esteban" sort="Mu Oz, Esteban" uniqKey="Mu Oz E" first="Esteban" last="Mu Oz">Esteban Mu Oz</name>
</author>
<author><name sortKey="Ezquerra, Mario" sort="Ezquerra, Mario" uniqKey="Ezquerra M" first="Mario" last="Ezquerra">Mario Ezquerra</name>
</author>
<author><name sortKey="Rios, Jose" sort="Rios, Jose" uniqKey="Rios J" first="Jose" last="Ríos">Jose Ríos</name>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
</author>
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<idno type="RBID">ISTEX:D3532C6682933CC0328E0C7334A7EA83065A6165</idno>
<date when="2009" year="2009">2009</date>
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<idno type="wicri:source">PubMed</idno>
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<idno type="wicri:Area/PubMed/Corpus">001B41</idno>
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<idno type="wicri:Area/Ncbi/Merge">002839</idno>
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<idno type="wicri:Area/Ncbi/Checkpoint">002839</idno>
<idno type="wicri:Area/Main/Merge">002C72</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cerebrospinal tau, phospho‐tau, and beta‐amyloid and neuropsychological functions in Parkinson's disease</title>
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<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="María J." last="Martí">María J. Martí</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry and Clinical Psychobiology IDIBAPS, CIBERNED, Faculty of Medicine, University of Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry and Clinical Psychobiology IDIBAPS, CIBERNED, Faculty of Medicine, University of Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mu Oz, Esteban" sort="Mu Oz, Esteban" uniqKey="Mu Oz E" first="Esteban" last="Mu Oz">Esteban Mu Oz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ezquerra, Mario" sort="Ezquerra, Mario" uniqKey="Ezquerra M" first="Mario" last="Ezquerra">Mario Ezquerra</name>
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<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rios, Jose" sort="Rios, Jose" uniqKey="Rios J" first="Jose" last="Ríos">Jose Ríos</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Statistics and Methodologic Support Unit, Unitat d'Avaluació, Suport i Prevenció (UASP), Hospital Clínic, IDIBAPS, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-11-15">2009-11-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2203">2203</biblScope>
<biblScope unit="page" to="2210">2210</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">D3532C6682933CC0328E0C7334A7EA83065A6165</idno>
<idno type="DOI">10.1002/mds.22594</idno>
<idno type="ArticleID">MDS22594</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Amyloid beta-Peptides (cerebrospinal fluid)</term>
<term>Case-Control Studies</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Processes (physiology)</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson's disease</term>
<term>Phosphorylation (physiology)</term>
<term>Retrospective Studies</term>
<term>Statistics as Topic</term>
<term>beta‐amyloid</term>
<term>cerebrospinal fluid</term>
<term>dementia</term>
<term>neuropsychological function</term>
<term>tau</term>
<term>tau Proteins (cerebrospinal fluid)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Mental Processes</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neuropsychological Tests</term>
<term>Retrospective Studies</term>
<term>Statistics as Topic</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD)‐pathology may play a role in Parkinson's disease (PD)‐related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho‐tau, and beta‐amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho‐tau, and beta‐amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto‐subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers levels were compared between groups, and compared and correlated with neuropsychological measures in PDND and PDD separately and as a continuum (PD). CSF tau and phospho‐tau were higher in PDD than in PDND and controls (P < 0.05). CSF beta‐amyloid ranged from high (controls) to intermediate (PDND) and low (PDD) levels (P < 0.001). In all PD and PDD patients, high CSF tau and phospho‐tau were associated with impaired memory and naming. In PDND, CSF beta‐amyloid was related with phonetic fluency. These findings suggest underlying AD‐pathology in PDD in association with cortical cognitive dysfunction, and that low CSF beta‐amyloid in PDND patients with impaired phonetic fluency can constitute an early marker of cognitive dysfunction. © 2009 Movement Disorder Society</div>
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