MovDisordV3, PascalFrancis, Corpus, bibRecord, 000E34

Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study

Identifieur interne : 000E34 ( PascalFrancis/Corpus ); précédent : 000E33; suivant : 000E35

Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study

Auteurs : Masato Kanazawa ; Takayoshi Shimohata ; Yasuko Toyoshima ; Mari Tada ; Akiyoshi Kakita ; Takashi Morita ; Tetsutaro Ozawa ; Hitoshi Takahashi ; Masatoyo Nishizawa

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0349916

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Cervelet, Ataxie spinocérébelleuse.

English descriptors

KwdEn :
- Cerebellum, Nervous system diseases, Parkinson disease, Spinocerebellar ataxia.

Abstract

The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 24`
A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study`
A11	`01`	`1`		`@1 KANAZAWA (Masato)`
A11	`02`	`1`		`@1 SHIMOHATA (Takayoshi)`
A11	`03`	`1`		`@1 TOYOSHIMA (Yasuko)`
A11	`04`	`1`		`@1 TADA (Mari)`
A11	`05`	`1`		`@1 KAKITA (Akiyoshi)`
A11	`06`	`1`		`@1 MORITA (Takashi)`
A11	`07`	`1`		`@1 OZAWA (Tetsutaro)`
A11	`08`	`1`		`@1 TAKAHASHI (Hitoshi)`
A11	`09`	`1`		`@1 NISHIZAWA (Masatoyo)`
A14	`01`			`@1 Department of Neurology, Brain Research Institute, Niigata University @2 Niigata @3 JPN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 7 aut. @Z 9 aut.`
A14	`02`			`@1 Department of Pathology, Brain Research Institute, Niigata University @2 Niigata @3 JPN @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 8 aut.`
A14	`03`			`@1 Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University @2 Niigata @3 JPN @Z 5 aut.`
A14	`04`			`@1 Department of Pathology, Shinrakuen Hospital @2 Niigata @3 JPN @Z 6 aut.`
A20				`@1 1312-1318`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000170902500080`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 26 ref.`
A47	`01`	`1`		`@0 09-0349916`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Cervelet @5 09`
C03	`03`	`X`	`ENG`	`@0 Cerebellum @5 09`
C03	`03`	`X`	`SPA`	`@0 Cerebelo @5 09`
C03	`04`	`X`	`FRE`	`@0 Ataxie spinocérébelleuse @2 NM @5 10`
C03	`04`	`X`	`ENG`	`@0 Spinocerebellar ataxia @2 NM @5 10`
C03	`04`	`X`	`SPA`	`@0 Ataxia spinocerebelosa @2 NM @5 10`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie héréditaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Genetic disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 43`
C07	`06`	`X`	`ENG`	`@0 Cerebral disorder @5 43`
C07	`06`	`X`	`SPA`	`@0 Encéfalo patología @5 43`
C07	`07`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 44`
C07	`07`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 44`
C07	`07`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 44`
N21				`@1 257`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0349916 INIST
ET :	Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study
AU :	KANAZAWA (Masato); SHIMOHATA (Takayoshi); TOYOSHIMA (Yasuko); TADA (Mari); KAKITA (Akiyoshi); MORITA (Takashi); OZAWA (Tetsutaro); TAKAHASHI (Hitoshi); NISHIZAWA (Masatoyo)
AF :	Department of Neurology, Brain Research Institute, Niigata University/Niigata/Japon (1 aut., 2 aut., 4 aut., 7 aut., 9 aut.); Department of Pathology, Brain Research Institute, Niigata University/Niigata/Japon (3 aut., 4 aut., 5 aut., 8 aut.); Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University/Niigata/Japon (5 aut.); Department of Pathology, Shinrakuen Hospital/Niigata/Japon (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1312-1318; Bibl. 26 ref.
LA :	Anglais
EA :	The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Cervelet; Ataxie spinocérébelleuse
FG :	Encéphale; Système nerveux central; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal
ED :	Parkinson disease; Nervous system diseases; Cerebellum; Spinocerebellar ataxia
EG :	Encephalon; Central nervous system; Degenerative disease; Genetic disease; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome
SD :	Parkinson enfermedad; Sistema nervioso patología; Cerebelo; Ataxia spinocerebelosa
LO :	INIST-20953.354000170902500080
ID :	09-0349916

Links to Exploration step

Pascal:09-0349916

Le document en format XML

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<author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study</title>
<author><name sortKey="Kanazawa, Masato" sort="Kanazawa, Masato" uniqKey="Kanazawa M" first="Masato" last="Kanazawa">Masato Kanazawa</name>
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<author><name sortKey="Toyoshima, Yasuko" sort="Toyoshima, Yasuko" uniqKey="Toyoshima Y" first="Yasuko" last="Toyoshima">Yasuko Toyoshima</name>
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<author><name sortKey="Tada, Mari" sort="Tada, Mari" uniqKey="Tada M" first="Mari" last="Tada">Mari Tada</name>
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<author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name>
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<author><name sortKey="Morita, Takashi" sort="Morita, Takashi" uniqKey="Morita T" first="Takashi" last="Morita">Takashi Morita</name>
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<author><name sortKey="Ozawa, Tetsutaro" sort="Ozawa, Tetsutaro" uniqKey="Ozawa T" first="Tetsutaro" last="Ozawa">Tetsutaro Ozawa</name>
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<author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Pathology, Brain Research Institute, Niigata University</s1>
<s2>Niigata</s2>
<s3>JPN</s3>
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<author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KANAZAWA (Masato)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SHIMOHATA (Takayoshi)</s1>
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<fA11 i1="03" i2="1"><s1>TOYOSHIMA (Yasuko)</s1>
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<fA11 i1="04" i2="1"><s1>TADA (Mari)</s1>
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<fA11 i1="05" i2="1"><s1>KAKITA (Akiyoshi)</s1>
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<fA11 i1="06" i2="1"><s1>MORITA (Takashi)</s1>
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<fA11 i1="07" i2="1"><s1>OZAWA (Tetsutaro)</s1>
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<fA11 i1="08" i2="1"><s1>TAKAHASHI (Hitoshi)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>NISHIZAWA (Masatoyo)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, Brain Research Institute, Niigata University</s1>
<s2>Niigata</s2>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Pathology, Brain Research Institute, Niigata University</s1>
<s2>Niigata</s2>
<s3>JPN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University</s1>
<s2>Niigata</s2>
<s3>JPN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Pathology, Shinrakuen Hospital</s1>
<s2>Niigata</s2>
<s3>JPN</s3>
<sZ>6 aut.</sZ>
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<fA20><s1>1312-1318</s1>
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<fA21><s1>2009</s1>
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<fA23 i1="01"><s0>ENG</s0>
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<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>26 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0349916</s0>
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<fC01 i1="01" l="ENG"><s0>The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.</s0>
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<fC02 i1="01" i2="X"><s0>002B17</s0>
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<fC02 i1="02" i2="X"><s0>002B17G</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
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<s5>09</s5>
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<s5>09</s5>
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<s2>NM</s2>
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<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
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<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
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<s5>39</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>43</s5>
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<s5>44</s5>
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<fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>44</s5>
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<fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>44</s5>
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<fN21><s1>257</s1>
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<server><NO>PASCAL 09-0349916 INIST</NO>
<ET>Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study</ET>
<AU>KANAZAWA (Masato); SHIMOHATA (Takayoshi); TOYOSHIMA (Yasuko); TADA (Mari); KAKITA (Akiyoshi); MORITA (Takashi); OZAWA (Tetsutaro); TAKAHASHI (Hitoshi); NISHIZAWA (Masatoyo)</AU>
<AF>Department of Neurology, Brain Research Institute, Niigata University/Niigata/Japon (1 aut., 2 aut., 4 aut., 7 aut., 9 aut.); Department of Pathology, Brain Research Institute, Niigata University/Niigata/Japon (3 aut., 4 aut., 5 aut., 8 aut.); Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University/Niigata/Japon (5 aut.); Department of Pathology, Shinrakuen Hospital/Niigata/Japon (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1312-1318; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Cervelet; Ataxie spinocérébelleuse</FD>
<FG>Encéphale; Système nerveux central; Maladie dégénérative; Maladie héréditaire; Pathologie du   système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal</FG>
<ED>Parkinson disease; Nervous system diseases; Cerebellum; Spinocerebellar ataxia</ED>
<EG>Encephalon; Central nervous system; Degenerative disease; Genetic disease; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Cerebelo; Ataxia spinocerebelosa</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study

Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study

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