MovDisordV3, Main, Curation, bibRecord, 002058

Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

Identifieur interne : 002058 ( Main/Curation ); précédent : 002057; suivant : 002059

Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

Auteurs : Nadeeka N. W. Dissanayaka [Australie] ; Peter A. Silburn [Australie] ; John D. O'Sullivan [Australie] ; George D. Mellick [Australie]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-01-15.

RBID : ISTEX:756C147B873B3C6304D7C96A9216C0996635C439

Descripteurs français

Pascal (Inist)
- Dopamine, Etat dépressif, Haplotype, Maladie de Parkinson, Pathologie du système nerveux, Transporteur sérotonine, Variant génétique.

English descriptors

KwdEn :
- Alleles, Depression, Depression (diagnosis), Depression (epidemiology), Depression (etiology), Depression (genetics), Depression (metabolism), Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (physiology), European Continental Ancestry Group (genetics), Genetic variant, Genotype, Haplotype, Haplotypes (genetics), Humans, Linkage Disequilibrium, Minisatellite Repeats, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Polymorphism, Single Nucleotide, Queensland (epidemiology), Questionnaires, SLC6A3, SLC6A4, Serotonin (metabolism), Serotonin Plasma Membrane Transport Proteins (genetics), Serotonin Plasma Membrane Transport Proteins (physiology), Serotonin transporter, depression, genetic variants, haplotypes.
MESH :
- chemical , genetics : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- chemical , metabolism : Dopamine, Serotonin.
- geographic , epidemiology : Queensland.
- complications : Parkinson Disease.
- diagnosis : Depression.
- epidemiology : Depression, Parkinson Disease.
- etiology : Depression.
- genetics : Depression, European Continental Ancestry Group, Haplotypes, Parkinson Disease.
- metabolism : Depression, Parkinson Disease.
- chemical , physiology : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- psychology : Parkinson Disease.
- Alleles, Genotype, Humans, Linkage Disequilibrium, Minisatellite Repeats, Polymorphism, Single Nucleotide, Questionnaires.

Abstract

Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/756C147B873B3C6304D7C96A9216C0996635C439/fulltext/pdf

DOI: 10.1002/mds.22134

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ISTEX:756C147B873B3C6304D7C96A9216C0996635C439

Le document en format XML

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<front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.</div>
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<front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

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