Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.
Identifieur interne : 001F51 ( PubMed/Curation ); précédent : 001F50; suivant : 001F52Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.
Auteurs : Nadeeka N W. Dissanayaka [Australie] ; Peter A. Silburn ; John D. O'Sullivan ; George D. MellickSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Alleles, Depression (diagnosis), Depression (epidemiology), Depression (etiology), Depression (genetics), Depression (metabolism), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (physiology), European Continental Ancestry Group (genetics), Genotype, Haplotypes (genetics), Humans, Linkage Disequilibrium, Minisatellite Repeats, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (psychology), Polymorphism, Single Nucleotide, Queensland (epidemiology), Questionnaires, Serotonin (metabolism), Serotonin Plasma Membrane Transport Proteins (genetics), Serotonin Plasma Membrane Transport Proteins (physiology).
- MESH :
- chemical , genetics : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- chemical , metabolism : Dopamine, Serotonin.
- geographic , epidemiology : Queensland.
- complications : Parkinson Disease.
- diagnosis : Depression.
- epidemiology : Depression, Parkinson Disease.
- etiology : Depression.
- genetics : Depression, European Continental Ancestry Group, Haplotypes, Parkinson Disease.
- metabolism : Depression, Parkinson Disease.
- chemical , physiology : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- psychology : Parkinson Disease.
- Alleles, Genotype, Humans, Linkage Disequilibrium, Minisatellite Repeats, Polymorphism, Single Nucleotide, Questionnaires.
Abstract
Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.
DOI: 10.1002/mds.22134
PubMed: 18973248
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O'Sullivan</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22134</idno><idno type="RBID">pubmed:18973248</idno><idno type="pmid">18973248</idno><idno type="wicri:Area/PubMed/Corpus">001F51</idno><idno type="wicri:Area/PubMed/Curation">001F51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.</title><author><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N W" last="Dissanayaka">Nadeeka N W. Dissanayaka</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Depression (diagnosis)</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Depression (genetics)</term><term>Depression (metabolism)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (physiology)</term><term>European Continental Ancestry Group (genetics)</term><term>Genotype</term><term>Haplotypes (genetics)</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Polymorphism, Single Nucleotide</term><term>Queensland (epidemiology)</term><term>Questionnaires</term><term>Serotonin (metabolism)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Queensland</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>European Continental Ancestry Group</term><term>Haplotypes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Polymorphism, Single Nucleotide</term><term>Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18973248</PMID><DateCreated><Year>2009</Year><Month>02</Month><Day>02</Day></DateCreated><DateCompleted><Year>2009</Year><Month>06</Month><Day>04</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dissanayaka</LastName><ForeName>Nadeeka N W</ForeName><Initials>NN</Initials><AffiliationInfo><Affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silburn</LastName><ForeName>Peter A</ForeName><Initials>PA</Initials></Author><Author ValidYN="Y"><LastName>O'Sullivan</LastName><ForeName>John D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Mellick</LastName><ForeName>George D</ForeName><Initials>GD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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