Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
Identifieur interne : 002919 ( Main/Merge ); précédent : 002918; suivant : 002920Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
Auteurs : Nadeeka N. W. Dissanayaka [Australie] ; Peter A. Silburn [Australie] ; John D. O'Sullivan [Australie] ; George D. Mellick [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-01-15.
English descriptors
- KwdEn :
- Alleles, Depression (diagnosis), Depression (epidemiology), Depression (etiology), Depression (genetics), Depression (metabolism), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (physiology), European Continental Ancestry Group (genetics), Genotype, Haplotypes (genetics), Humans, Linkage Disequilibrium, Minisatellite Repeats, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (psychology), Parkinson's disease, Polymorphism, Single Nucleotide, Queensland (epidemiology), Questionnaires, SLC6A3, SLC6A4, Serotonin (metabolism), Serotonin Plasma Membrane Transport Proteins (genetics), Serotonin Plasma Membrane Transport Proteins (physiology), depression, genetic variants, haplotypes.
- MESH :
- chemical , genetics : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- chemical , metabolism : Dopamine, Serotonin.
- geographic , epidemiology : Queensland.
- complications : Parkinson Disease.
- diagnosis : Depression.
- epidemiology : Depression, Parkinson Disease.
- etiology : Depression.
- genetics : Depression, European Continental Ancestry Group, Haplotypes, Parkinson Disease.
- metabolism : Depression, Parkinson Disease.
- chemical , physiology : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- psychology : Parkinson Disease.
- Alleles, Genotype, Humans, Linkage Disequilibrium, Minisatellite Repeats, Polymorphism, Single Nucleotide, Questionnaires.
Abstract
Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22134
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W." last="Dissanayaka">Nadeeka N. W. Dissanayaka</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. 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O'Sullivan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-15">2009-01-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="111">111</biblScope><biblScope unit="page" to="115">115</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">756C147B873B3C6304D7C96A9216C0996635C439</idno><idno type="DOI">10.1002/mds.22134</idno><idno type="ArticleID">MDS22134</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Depression (diagnosis)</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Depression (genetics)</term><term>Depression (metabolism)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (physiology)</term><term>European Continental Ancestry Group (genetics)</term><term>Genotype</term><term>Haplotypes (genetics)</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Parkinson's disease</term><term>Polymorphism, Single Nucleotide</term><term>Queensland (epidemiology)</term><term>Questionnaires</term><term>SLC6A3</term><term>SLC6A4</term><term>Serotonin (metabolism)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (physiology)</term><term>depression</term><term>genetic variants</term><term>haplotypes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Queensland</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>European Continental Ancestry Group</term><term>Haplotypes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Polymorphism, Single Nucleotide</term><term>Questionnaires</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.22134"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease</title><author><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N. W." last="Dissanayaka">Nadeeka N. W. Dissanayaka</name></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:756C147B873B3C6304D7C96A9216C0996635C439</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22134</idno><idno type="url">https://api.istex.fr/document/756C147B873B3C6304D7C96A9216C0996635C439/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001478</idno><idno type="wicri:Area/Istex/Curation">001478</idno><idno type="wicri:Area/Istex/Checkpoint">000C60</idno><idno type="wicri:doubleKey">0885-3185:2009:Dissanayaka N:serotonin:and:dopamine</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease</title><author><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N. W." last="Dissanayaka">Nadeeka N. W. Dissanayaka</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-15">2009-01-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="111">111</biblScope><biblScope unit="page" to="115">115</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">756C147B873B3C6304D7C96A9216C0996635C439</idno><idno type="DOI">10.1002/mds.22134</idno><idno type="ArticleID">MDS22134</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SLC6A3</term><term>SLC6A4</term><term>depression</term><term>genetic variants</term><term>haplotypes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.</title><author><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N W" last="Dissanayaka">Nadeeka N W. Dissanayaka</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22134</idno><idno type="RBID">pubmed:18973248</idno><idno type="pmid">18973248</idno><idno type="wicri:Area/PubMed/Corpus">001F51</idno><idno type="wicri:Area/PubMed/Curation">001F51</idno><idno type="wicri:Area/PubMed/Checkpoint">001B72</idno><idno type="wicri:Area/Ncbi/Merge">002412</idno><idno type="wicri:Area/Ncbi/Curation">002412</idno><idno type="wicri:Area/Ncbi/Checkpoint">002412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.</title><author><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N W" last="Dissanayaka">Nadeeka N W. Dissanayaka</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Depression (diagnosis)</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Depression (genetics)</term><term>Depression (metabolism)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (physiology)</term><term>European Continental Ancestry Group (genetics)</term><term>Genotype</term><term>Haplotypes (genetics)</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Polymorphism, Single Nucleotide</term><term>Queensland (epidemiology)</term><term>Questionnaires</term><term>Serotonin (metabolism)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Queensland</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>European Continental Ancestry Group</term><term>Haplotypes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Polymorphism, Single Nucleotide</term><term>Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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