MovDisordV3, Main, Curation, bibRecord, 001A12

Sensory disinhibition on passive movement in cervical dystonia

Identifieur interne : 001A12 ( Main/Curation ); précédent : 001A11; suivant : 001A13

Sensory disinhibition on passive movement in cervical dystonia

Auteurs : Mark Obermann [Allemagne] ; Clemens Vollrath [Allemagne] ; Armin De Greiff [Allemagne] ; Elke R. Gizewski [Allemagne] ; Hans-Christoph Diener [Allemagne] ; Mark Hallett [États-Unis] ; Matthias Maschke [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-11-15.

RBID : ISTEX:47AD29344CA431C77320B05B89F3312534E4BEFE

Descripteurs français

Pascal (Inist)
- Dystonie, Imagerie RMN, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Botulinum Toxins, Type A (therapeutic use), Brain Mapping, Dystonia, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (physiopathology), Movement (physiology), Nervous system diseases, Nuclear magnetic resonance imaging, Somatosensory Cortex (physiopathology), Torticollis (physiopathology), Torticollis (therapy), cervical dystonia, cortical disinhibition, fMRI, focal dystonia, somatosensory system.
MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A.
- physiology : Movement.
- physiopathology : Motor Cortex, Somatosensory Cortex, Torticollis.
- therapy : Torticollis.
- Aged, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30‐degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT‐A; Dysport®). Patients with CD showed BOLD‐signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT‐A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor‐system or the direct neuronal representation of the affected dystonic musculature alone. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/47AD29344CA431C77320B05B89F3312534E4BEFE/fulltext/pdf

DOI: 10.1002/mds.23321

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<front><div type="abstract" xml:lang="en">The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30‐degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT‐A; Dysport®). Patients with CD showed BOLD‐signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT‐A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor‐system or the direct neuronal representation of the affected dystonic musculature alone. © 2010 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.</div>
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<front><div type="abstract" xml:lang="en">The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30‐degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT‐A; Dysport®). Patients with CD showed BOLD‐signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT‐A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor‐system or the direct neuronal representation of the affected dystonic musculature alone. © 2010 Movement Disorder Society</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Sensory disinhibition on passive movement in cervical dystonia

Sensory disinhibition on passive movement in cervical dystonia

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