MovDisordV3, PascalFrancis, Corpus, bibRecord, 000806

Sensory Disinhibition on Passive Movement in Cervical Dystonia

Identifieur interne : 000806 ( PascalFrancis/Corpus ); précédent : 000805; suivant : 000807

Sensory Disinhibition on Passive Movement in Cervical Dystonia

Auteurs : Mark Obermann ; Clemens Vollrath ; Armin De Greiff ; Elke R. Gizewski ; Hans-Christoph Diener ; Mark Hallett ; Matthias Maschke

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0512940

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Imagerie RMN.

English descriptors

KwdEn :
- Dystonia, Nervous system diseases, Nuclear magnetic resonance imaging.

Abstract

The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 25`
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A08	`01`	`1`	`ENG`	`@1 Sensory Disinhibition on Passive Movement in Cervical Dystonia`
A11	`01`	`1`		`@1 OBERMANN (Mark)`
A11	`02`	`1`		`@1 VOLLRATH (Clemens)`
A11	`03`	`1`		`@1 DE GREIFF (Armin)`
A11	`04`	`1`		`@1 GIZEWSKI (Elke R.)`
A11	`05`	`1`		`@1 DIENER (Hans-Christoph)`
A11	`06`	`1`		`@1 HALLETT (Mark)`
A11	`07`	`1`		`@1 MASCHKE (Matthias)`
A14	`01`			`@1 Department of Neurology, University of Duisburg-Essen @3 DEU @Z 1 aut. @Z 2 aut. @Z 5 aut. @Z 7 aut.`
A14	`02`			`@1 Department of Neuroradiology, University of Duisburg-Essen @3 DEU @Z 3 aut. @Z 4 aut.`
A14	`03`			`@1 Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) @2 Bethesda, Maryland @3 USA @Z 6 aut.`
A14	`04`			`@1 Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier @3 DEU @Z 7 aut.`
A20				`@1 2627-2633`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000191411680210`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 10-0512940`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.
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C02	`02`	`X`		`@0 002B17H`
C03	`01`	`X`	`FRE`	`@0 Dystonie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dystonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Distonía @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Imagerie RMN @5 09`
C03	`03`	`X`	`ENG`	`@0 Nuclear magnetic resonance imaging @5 09`
C03	`03`	`X`	`SPA`	`@0 Imaginería RMN @5 09`
C07	`01`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 37`
C07	`01`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`01`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`02`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`02`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`02`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 39`
C07	`03`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
C07	`05`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 42`
C07	`05`	`X`	`ENG`	`@0 Cerebral disorder @5 42`
C07	`05`	`X`	`SPA`	`@0 Encéfalo patología @5 42`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 43`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 43`
N21				`@1 347`
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Format Inist (serveur)

NO :	PASCAL 10-0512940 INIST
ET :	Sensory Disinhibition on Passive Movement in Cervical Dystonia
AU :	OBERMANN (Mark); VOLLRATH (Clemens); DE GREIFF (Armin); GIZEWSKI (Elke R.); DIENER (Hans-Christoph); HALLETT (Mark); MASCHKE (Matthias)
AF :	Department of Neurology, University of Duisburg-Essen/Allemagne (1 aut., 2 aut., 5 aut., 7 aut.); Department of Neuroradiology, University of Duisburg-Essen/Allemagne (3 aut., 4 aut.); Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH)/Bethesda, Maryland/Etats-Unis (6 aut.); Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier/Allemagne (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 15; Pp. 2627-2633; Bibl. 33 ref.
LA :	Anglais
EA :	The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.
CC :	002B17; 002B17H
FD :	Dystonie; Pathologie du système nerveux; Imagerie RMN
FG :	Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Dystonia; Nervous system diseases; Nuclear magnetic resonance imaging
EG :	Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease
SD :	Distonía; Sistema nervioso patología; Imaginería RMN
LO :	INIST-20953.354000191411680210
ID :	10-0512940

Links to Exploration step

Pascal:10-0512940

Le document en format XML

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<front><div type="abstract" xml:lang="en">The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.</div>
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<s5>42</s5>
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<s5>43</s5>
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<server><NO>PASCAL 10-0512940 INIST</NO>
<ET>Sensory Disinhibition on Passive Movement in Cervical Dystonia</ET>
<AU>OBERMANN (Mark); VOLLRATH (Clemens); DE GREIFF (Armin); GIZEWSKI (Elke R.); DIENER (Hans-Christoph); HALLETT (Mark); MASCHKE (Matthias)</AU>
<AF>Department of Neurology, University of Duisburg-Essen/Allemagne (1 aut., 2 aut., 5 aut., 7 aut.); Department of Neuroradiology, University of Duisburg-Essen/Allemagne (3 aut., 4 aut.); Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH)/Bethesda, Maryland/Etats-Unis (6 aut.); Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier/Allemagne (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 15; Pp. 2627-2633; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.</EA>
<CC>002B17; 002B17H</CC>
<FD>Dystonie; Pathologie du   système nerveux; Imagerie RMN</FD>
<FG>Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Dystonia; Nervous system diseases; Nuclear magnetic resonance imaging</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease</EG>
<SD>Distonía; Sistema nervioso patología; Imaginería RMN</SD>
<LO>INIST-20953.354000191411680210</LO>
<ID>10-0512940</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Sensory Disinhibition on Passive Movement in Cervical Dystonia

Sensory Disinhibition on Passive Movement in Cervical Dystonia

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