MovDisordV3, PubMed, Corpus, bibRecord, 001614

Sensory disinhibition on passive movement in cervical dystonia.

Identifieur interne : 001614 ( PubMed/Corpus ); précédent : 001613; suivant : 001615

Sensory disinhibition on passive movement in cervical dystonia.

Auteurs : Mark Obermann ; Clemens Vollrath ; Armin De Greiff ; Elke R. Gizewski ; Hans-Christoph Diener ; Mark Hallett ; Matthias Maschke

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.

RBID : pubmed:20725914

English descriptors

KwdEn :
- Aged, Botulinum Toxins, Type A (therapeutic use), Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (physiopathology), Movement (physiology), Somatosensory Cortex (physiopathology), Torticollis (physiopathology), Torticollis (therapy).
MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A.
- physiology : Movement.
- physiopathology : Motor Cortex, Somatosensory Cortex, Torticollis.
- therapy : Torticollis.
- Aged, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.

DOI: 10.1002/mds.23321
PubMed: 20725914

Links to Exploration step

pubmed:20725914

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sensory disinhibition on passive movement in cervical dystonia.</title>
<author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Duisburg-Essen, Essen, Germany. mark.obermann@uni-due.de</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vollrath, Clemens" sort="Vollrath, Clemens" uniqKey="Vollrath C" first="Clemens" last="Vollrath">Clemens Vollrath</name>
</author>
<author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name>
</author>
<author><name sortKey="Gizewski, Elke R" sort="Gizewski, Elke R" uniqKey="Gizewski E" first="Elke R" last="Gizewski">Elke R. Gizewski</name>
</author>
<author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
</author>
<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
</author>
<author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="doi">10.1002/mds.23321</idno>
<idno type="RBID">pubmed:20725914</idno>
<idno type="pmid">20725914</idno>
<idno type="wicri:Area/PubMed/Corpus">001614</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Sensory disinhibition on passive movement in cervical dystonia.</title>
<author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Duisburg-Essen, Essen, Germany. mark.obermann@uni-due.de</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vollrath, Clemens" sort="Vollrath, Clemens" uniqKey="Vollrath C" first="Clemens" last="Vollrath">Clemens Vollrath</name>
</author>
<author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name>
</author>
<author><name sortKey="Gizewski, Elke R" sort="Gizewski, Elke R" uniqKey="Gizewski E" first="Elke R" last="Gizewski">Elke R. Gizewski</name>
</author>
<author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
</author>
<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
</author>
<author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Botulinum Toxins, Type A (therapeutic use)</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Cortex (physiopathology)</term>
<term>Movement (physiology)</term>
<term>Somatosensory Cortex (physiopathology)</term>
<term>Torticollis (physiopathology)</term>
<term>Torticollis (therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term>
<term>Somatosensory Cortex</term>
<term>Torticollis</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Torticollis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20725914</PMID>
<DateCreated><Year>2010</Year>
<Month>11</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>02</Month>
<Day>25</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>15</Issue>
<PubDate><Year>2010</Year>
<Month>Nov</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Sensory disinhibition on passive movement in cervical dystonia.</ArticleTitle>
<Pagination><MedlinePgn>2627-33</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23321</ELocationID>
<Abstract><AbstractText>The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30-degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT-A; Dysport®). Patients with CD showed BOLD-signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT-A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone.</AbstractText>
<CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Obermann</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Duisburg-Essen, Essen, Germany. mark.obermann@uni-due.de</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vollrath</LastName>
<ForeName>Clemens</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>de Greiff</LastName>
<ForeName>Armin</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gizewski</LastName>
<ForeName>Elke R</ForeName>
<Initials>ER</Initials>
</Author>
<Author ValidYN="Y"><LastName>Diener</LastName>
<ForeName>Hans-Christoph</ForeName>
<Initials>HC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hallett</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Maschke</LastName>
<ForeName>Matthias</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 3.4.24.69</RegistryNumber>
<NameOfSubstance UI="D019274">Botulinum Toxins, Type A</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D019274">Botulinum Toxins, Type A</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009068">Movement</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D013003">Somatosensory Cortex</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014103">Torticollis</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>8</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>8</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.23321</ArticleId>
<ArticleId IdType="pubmed">20725914</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001614 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001614 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:20725914
   |texte=   Sensory disinhibition on passive movement in cervical dystonia.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:20725914" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Sensory disinhibition on passive movement in cervical dystonia.

Sensory disinhibition on passive movement in cervical dystonia.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki