Motor behavior abnormalities in drug‐naïve patients with schizophrenia spectrum disorders
Identifieur interne : 000352 ( Istex/Curation ); précédent : 000351; suivant : 000353Motor behavior abnormalities in drug‐naïve patients with schizophrenia spectrum disorders
Auteurs : Victor Peralta [Espagne] ; Maria S. Campos [Espagne] ; Elena García De Jal N [Espagne] ; Manuel J. Cuesta [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
English descriptors
- KwdEn :
Abstract
Prevalence and correlates of primary motor abnormalities in schizophrenia are presently ill defined. This study was aimed at examining the prevalence, syndromic structure, external correlates, and response to antipsychotic medication of a broad array of primary motor abnormalities. Two‐hundred antipsychotic‐naive patients with schizophrenia spectrum disorders were examined for motor abnormalities using the Modified Rogers Scale. Thirty‐one motor signs were subjected to factor analysis, and the resulting factors examined for association with a number of risk factors, clinical and psychopathological variables. One‐hundred and eighty‐nine patients were reassessed for motor abnormalities after completing a 4‐week trial with antipsychotic medication. Prevalence rates for at least one motor sign and syndrome at baseline were 66% and 40%, respectively. Motor signs clustered together into seven clinically interpretable factors: abnormal involuntary movements, hypokinesia, retarded catatonia, echo‐phenomena, excited catatonia, catalepsy, and parkinsonism. All motor domains but parkinsonism were inter‐related. Abnormal involuntary movements were associated with variables indicating both neurodevelopmental dysfunction and illness severity, and most motor domains were closely related to negative or disorganization symptoms. Change scores in motor domains after treatment with antipsychotic medication indicated improvement for abnormal involuntary movements, hypokinesia, retarded catatonia, excited catatonia and echophenomena, and worsening for parkinsonism. It is concluded that primary motor dysfunction is a prevalent and heterogeneous condition of schizophrenia. Motor abnormalities segregate into various syndromes, which have different clinical correlates and a differential response pattern to antipsychotic medication. It is hypothesized that the existence of a differential dopaminergic dysfunction in the nigroestriatal circuitry is responsible for the generation of those motor domains that improve and worsen with antipsychotic drugs. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23050
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000352
Links to Exploration step
ISTEX:97A26A80FADED766EFBC5964EB8F004FE0F3F083Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Motor behavior abnormalities in drug‐naïve patients with schizophrenia spectrum disorders</title>
<author><name sortKey="Peralta, Victor" sort="Peralta, Victor" uniqKey="Peralta V" first="Victor" last="Peralta">Victor Peralta</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campos, Maria S" sort="Campos, Maria S" uniqKey="Campos M" first="Maria S." last="Campos">Maria S. Campos</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Jal N, Elena Garcia" sort="De Jal N, Elena Garcia" uniqKey="De Jal N E" first="Elena García" last="De Jal N">Elena García De Jal N</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuesta, Manuel J" sort="Cuesta, Manuel J" uniqKey="Cuesta M" first="Manuel J." last="Cuesta">Manuel J. Cuesta</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:97A26A80FADED766EFBC5964EB8F004FE0F3F083</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23050</idno>
<idno type="url">https://api.istex.fr/document/97A26A80FADED766EFBC5964EB8F004FE0F3F083/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000352</idno>
<idno type="wicri:Area/Istex/Curation">000352</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Motor behavior abnormalities in drug‐naïve patients with schizophrenia spectrum disorders</title>
<author><name sortKey="Peralta, Victor" sort="Peralta, Victor" uniqKey="Peralta V" first="Victor" last="Peralta">Victor Peralta</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campos, Maria S" sort="Campos, Maria S" uniqKey="Campos M" first="Maria S." last="Campos">Maria S. Campos</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Jal N, Elena Garcia" sort="De Jal N, Elena Garcia" uniqKey="De Jal N E" first="Elena García" last="De Jal N">Elena García De Jal N</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuesta, Manuel J" sort="Cuesta, Manuel J" uniqKey="Cuesta M" first="Manuel J." last="Cuesta">Manuel J. Cuesta</name>
<affiliation wicri:level="1"><mods:affiliation>Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Psychiatric Unit, Virgen del Camino Hospital, Pamplona</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-06-15">2010-06-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1068">1068</biblScope>
<biblScope unit="page" to="1076">1076</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">97A26A80FADED766EFBC5964EB8F004FE0F3F083</idno>
<idno type="DOI">10.1002/mds.23050</idno>
<idno type="ArticleID">MDS23050</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antipsychotics</term>
<term>catatonic signs</term>
<term>extrapyramidal signs</term>
<term>factor structure</term>
<term>motor abnormalities</term>
<term>schizophrenia</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Prevalence and correlates of primary motor abnormalities in schizophrenia are presently ill defined. This study was aimed at examining the prevalence, syndromic structure, external correlates, and response to antipsychotic medication of a broad array of primary motor abnormalities. Two‐hundred antipsychotic‐naive patients with schizophrenia spectrum disorders were examined for motor abnormalities using the Modified Rogers Scale. Thirty‐one motor signs were subjected to factor analysis, and the resulting factors examined for association with a number of risk factors, clinical and psychopathological variables. One‐hundred and eighty‐nine patients were reassessed for motor abnormalities after completing a 4‐week trial with antipsychotic medication. Prevalence rates for at least one motor sign and syndrome at baseline were 66% and 40%, respectively. Motor signs clustered together into seven clinically interpretable factors: abnormal involuntary movements, hypokinesia, retarded catatonia, echo‐phenomena, excited catatonia, catalepsy, and parkinsonism. All motor domains but parkinsonism were inter‐related. Abnormal involuntary movements were associated with variables indicating both neurodevelopmental dysfunction and illness severity, and most motor domains were closely related to negative or disorganization symptoms. Change scores in motor domains after treatment with antipsychotic medication indicated improvement for abnormal involuntary movements, hypokinesia, retarded catatonia, excited catatonia and echophenomena, and worsening for parkinsonism. It is concluded that primary motor dysfunction is a prevalent and heterogeneous condition of schizophrenia. Motor abnormalities segregate into various syndromes, which have different clinical correlates and a differential response pattern to antipsychotic medication. It is hypothesized that the existence of a differential dopaminergic dysfunction in the nigroestriatal circuitry is responsible for the generation of those motor domains that improve and worsen with antipsychotic drugs. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000352 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000352 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:97A26A80FADED766EFBC5964EB8F004FE0F3F083 |texte= Motor behavior abnormalities in drug‐naïve patients with schizophrenia spectrum disorders }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |