How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
Identifieur interne : 002123 ( Istex/Corpus ); précédent : 002122; suivant : 002124How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
Auteurs : Lindsey Kirsch-Darrow ; Laura B. Zahodne ; Chris Hass ; Ania Mikos ; Michael S. Okun ; Hubert H. Fernandez ; Dawn BowersSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
- KwdEn :
Abstract
Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22437
Links to Exploration step
ISTEX:A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title><author><name sortKey="Kirsch Arrow, Lindsey" sort="Kirsch Arrow, Lindsey" uniqKey="Kirsch Arrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Hass, Chris" sort="Hass, Chris" uniqKey="Hass C" first="Chris" last="Hass">Chris Hass</name><affiliation><mods:affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Mikos, Ania" sort="Mikos, Ania" uniqKey="Mikos A" first="Ania" last="Mikos">Ania Mikos</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation><mods:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation><mods:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22437</idno><idno type="url">https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002123</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title><author><name sortKey="Kirsch Arrow, Lindsey" sort="Kirsch Arrow, Lindsey" uniqKey="Kirsch Arrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Hass, Chris" sort="Hass, Chris" uniqKey="Hass C" first="Chris" last="Hass">Chris Hass</name><affiliation><mods:affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Mikos, Ania" sort="Mikos, Ania" uniqKey="Mikos A" first="Ania" last="Mikos">Ania Mikos</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation><mods:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation><mods:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="684">684</biblScope><biblScope unit="page" to="688">688</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</idno><idno type="DOI">10.1002/mds.22437</idno><idno type="ArticleID">MDS22437</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>UPDRS</term><term>apathy</term><term>assessment</term><term>mood disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lindsey Kirsch‐Darrow MS</name><affiliations><json:string>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Laura B. Zahodne MS</name><affiliations><json:string>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Chris Hass PhD</name><affiliations><json:string>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Ania Mikos PhD</name><affiliations><json:string>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Michael S. Okun MD</name><affiliations><json:string>Department of Neurology, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Hubert H. Fernandez MD</name><affiliations><json:string>Department of Neurology, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Dawn Bowers PhD</name><affiliations><json:string>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>apathy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mood disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>UPDRS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>assessment</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>5.061</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1205</abstractCharCount><pdfWordCount>2733</pdfWordCount><pdfCharCount>16365</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>194</abstractWordCount></qualityIndicators><title>How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>5</total><last>688</last><first>684</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22437</json:string></doi><id>A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note><note>Unknown funding agency - No. F31‐NS059142; No. R01‐NS05063; No. K23‐NS044997;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title><author><persName><forename type="first">Lindsey</forename><surname>Kirsch‐Darrow</surname><roleName type="degree">MS</roleName></persName><note type="correspondence"><p>Correspondence: Box 100165, Department of Clinical & Health Psychology, University of Florida, 101 South Newell Drive room 3151, Gainesville, FL 32610‐0165</p></note><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Laura B.</forename><surname>Zahodne</surname><roleName type="degree">MS</roleName></persName><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Chris</forename><surname>Hass</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Ania</forename><surname>Mikos</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Michael S.</forename><surname>Okun</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Hubert H.</forename><surname>Fernandez</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Dawn</forename><surname>Bowers</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15"></date><biblScope unit="vol">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="684">684</biblScope><biblScope unit="page" to="688">688</biblScope></imprint></monogr><idno type="istex">A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</idno><idno type="DOI">10.1002/mds.22437</idno><idno type="ArticleID">MDS22437</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>apathy</term></item><item><term>mood disorders</term></item><item><term>UPDRS</term></item><item><term>assessment</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05-27">Received</change><change when="2008-11-18">Registration</change><change when="2009-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v24:5</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2009-04-15">15 April 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="80" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22437</doi><idGroup><id type="unit" value="MDS22437"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-05-27"></event><event type="manuscriptRevised" date="2008-11-09"></event><event type="manuscriptAccepted" date="2008-11-18"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-01-30"></event><event type="firstOnline" date="2009-01-30"></event><event type="publishedOnlineFinalForm" date="2009-04-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">684</numbering><numbering type="pageLast">688</numbering></numberingGroup><correspondenceTo>Box 100165, Department of Clinical & Health Psychology, University of Florida, 101 South Newell Drive room 3151, Gainesville, FL 32610‐0165</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22437.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="15"></count><count type="wordTotal" number="3301"></count></countGroup><titleGroup><title type="main" xml:lang="en">How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?<link href="#fn1"></link></title><title type="short" xml:lang="en">Assessing Apathy with the UPDRS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Lindsey</givenNames><familyName>Kirsch‐Darrow</familyName><degrees>MS</degrees></personName><contactDetails><email>lkirsch@phhp.ufl.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Laura B.</givenNames><familyName>Zahodne</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Chris</givenNames><familyName>Hass</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ania</givenNames><familyName>Mikos</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Michael S.</givenNames><familyName>Okun</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Hubert H.</givenNames><familyName>Fernandez</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dawn</givenNames><familyName>Bowers</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">apathy</keyword><keyword xml:id="kwd3">mood disorders</keyword><keyword xml:id="kwd4">UPDRS</keyword><keyword xml:id="kwd5">assessment</keyword></keywordGroup><fundingInfo><fundingAgency>Unknown funding agency</fundingAgency><fundingNumber>F31‐NS059142</fundingNumber><fundingNumber>R01‐NS05063</fundingNumber><fundingNumber>K23‐NS044997</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Assessing Apathy with the UPDRS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?</title></titleInfo><name type="personal"><namePart type="given">Lindsey</namePart><namePart type="family">Kirsch‐Darrow</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation><description>Correspondence: Box 100165, Department of Clinical & Health Psychology, University of Florida, 101 South Newell Drive room 3151, Gainesville, FL 32610‐0165</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura B.</namePart><namePart type="family">Zahodne</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chris</namePart><namePart type="family">Hass</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ania</namePart><namePart type="family">Mikos</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael S.</namePart><namePart type="family">Okun</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hubert H.</namePart><namePart type="family">Fernandez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dawn</namePart><namePart type="family">Bowers</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-04-15</dateIssued><dateCaptured encoding="w3cdtf">2008-05-27</dateCaptured><dateValid encoding="w3cdtf">2008-11-18</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">15</extent><extent unit="words">3301</extent></physicalDescription><abstract lang="en">Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Unknown funding agency - No. F31‐NS059142; No. R01‐NS05063; No. K23‐NS044997; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>apathy</topic><topic>mood disorders</topic><topic>UPDRS</topic><topic>assessment</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>684</start><end>688</end><total>5</total></extent></part></relatedItem><identifier type="istex">A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</identifier><identifier type="DOI">10.1002/mds.22437</identifier><identifier type="ArticleID">MDS22437</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002123 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002123 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9
|texte= How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
}}
| This area was generated with Dilib version V0.6.23. |  |