Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease
Identifieur interne : 001374 ( Istex/Corpus ); précédent : 001373; suivant : 001375Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease
Auteurs : Bruno Fimm ; Ines A. Heber ; Volker A. Coenen ; Christoph Fromm ; Johannes Noth ; Martin KronenbuergerSource :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
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Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22580
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Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Bruno Fimm PhD</name><affiliations><json:string>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Ines A. Heber PhD</name><affiliations><json:string>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Volker A. Coenen MD</name><affiliations><json:string>Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Christoph Fromm MD</name><affiliations><json:string>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Johannes Noth MD</name><affiliations><json:string>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Martin Kronenbuerger MD</name><affiliations><json:string>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>fronto‐parietal network</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>attention</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. 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type="main">Abstract</title><p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn5"><p>Potential conflict of interest: None reported.</p></note><note xml:id="fn4"><p>Bruno Fimm and Martin Kronenbuerger contributed equally to this manuscript.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STN Stimulation Improves Intrinsic Alertness</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Fimm</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany</affiliation><description>Bruno Fimm and Martin Kronenbuerger contributed equally to this manuscript.</description><description>Correspondence: Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen, Pauwelsstraβe 30, D‐52074 Aachen, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ines A.</namePart><namePart type="family">Heber</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Volker A.</namePart><namePart type="family">Coenen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Fromm</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes</namePart><namePart type="family">Noth</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Kronenbuerger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany</affiliation><description>Bruno Fimm and Martin Kronenbuerger contributed equally to this manuscript.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-08-15</dateIssued><dateCaptured encoding="w3cdtf">2008-01-10</dateCaptured><dateValid encoding="w3cdtf">2009-03-08</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">47</extent><extent unit="words">5567</extent></physicalDescription><abstract lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">START‐Program - No. 49/05; </note><subject lang="en"><genre>Keywords</genre><topic>fronto‐parietal network</topic><topic>attention</topic><topic>cognition</topic><topic>basal ganglia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1613</start><end>1620</end><total>8</total></extent></part></relatedItem><identifier type="istex">C5B48B5E21926C8B81620CAB6CC17DDF49DCD3E7</identifier><identifier type="DOI">10.1002/mds.22580</identifier><identifier type="ArticleID">MDS22580</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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