Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements
Identifieur interne : 001375 ( Istex/Corpus ); précédent : 001374; suivant : 001376Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements
Auteurs : Roland Wenzelburger ; Florian Kopper ; Bao-Rong Zhang ; Karsten Witt ; Wolfgang Hamel ; Dieter Weinert ; Johann Kuhtz-Buschbeck ; Mukaddes Gölge ; Michael Illert ; Günther Deuschl ; Paul KrackSource :
- Movement Disorders [ 0885-3185 ] ; 2003-10.
English descriptors
Abstract
Deep brain stimulation of the subthalamic nucleus (STN‐DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. This suggests that routine STN‐DBS might not be equally effective on all aspects of fine motor functions. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10501
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ISTEX:630F30341523B3232FC289FD145F8E9C28ED775DLe document en format XML
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We assessed the effects of DBS and a levodopa (L‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. This suggests that routine STN‐DBS might not be equally effective on all aspects of fine motor functions. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Roland Wenzelburger MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Florian Kopper MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Bao‐Rong Zhang MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Karsten Witt MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang Hamel MD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Dieter Weinert MD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Johann Kuhtz‐Buschbeck MD</name><affiliations><json:string>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Mukaddes Gölge PhD</name><affiliations><json:string>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Michael Illert PhD</name><affiliations><json:string>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Günther Deuschl PhD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Paul Krack PhD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>akinesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>grip force</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Deep brain stimulation of the subthalamic nucleus (STN‐DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. 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No. 01KO9811/7;</note><note>Kompetenznetzwerk Parkinson</note><note>Kiel University</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements</title><author><persName><forename type="first">Roland</forename><surname>Wenzelburger</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Florian</forename><surname>Kopper</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Bao‐Rong</forename><surname>Zhang</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Karsten</forename><surname>Witt</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Wolfgang</forename><surname>Hamel</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Dieter</forename><surname>Weinert</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Johann</forename><surname>Kuhtz‐Buschbeck</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Mukaddes</forename><surname>Gölge</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Illert</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Günther</forename><surname>Deuschl</surname><roleName type="degree">PhD</roleName></persName><note type="correspondence"><p>Correspondence: Neurologische Klinik der, Christian‐Albrechts‐Universität zu Kiel, Niemannsweg 147, 2405 Kiel, 24105 Kiel, Germany</p></note><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Paul</forename><surname>Krack</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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href="file:MDS.MDS10501.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="53"></count><count type="wordTotal" number="5122"></count></countGroup><titleGroup><title type="main" xml:lang="en">Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements</title><title type="short" xml:lang="en">STN‐DBS and Proximal Appendicular Akinesia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roland</givenNames><familyName>Wenzelburger</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Florian</givenNames><familyName>Kopper</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Bao‐Rong</givenNames><familyName>Zhang</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Karsten</givenNames><familyName>Witt</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Wolfgang</givenNames><familyName>Hamel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dieter</givenNames><familyName>Weinert</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Johann</givenNames><familyName>Kuhtz‐Buschbeck</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Mukaddes</givenNames><familyName>Gölge</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Michael</givenNames><familyName>Illert</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Günther</givenNames><familyName>Deuschl</familyName><degrees>PhD</degrees></personName><contactDetails><email normalForm="g.deuschl@neurologie.uni-kiel.de">g.deuschl@neurologie.uni‐kiel.de</email></contactDetails></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paul</givenNames><familyName>Krack</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">akinesia</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">deep brain stimulation</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">grip force</keyword></keywordGroup><fundingInfo><fundingAgency>Deutsche Forschungsgemeinsschaft</fundingAgency><fundingNumber>01KO9811/7</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Kompetenznetzwerk Parkinson</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Kiel University</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Deep brain stimulation of the subthalamic nucleus (STN‐DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (<sc>L</sc>‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the <sc>L</sc>‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. This suggests that routine STN‐DBS might not be equally effective on all aspects of fine motor functions. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STN‐DBS and Proximal Appendicular Akinesia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements</title></titleInfo><name type="personal"><namePart type="given">Roland</namePart><namePart type="family">Wenzelburger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Florian</namePart><namePart type="family">Kopper</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bao‐Rong</namePart><namePart type="family">Zhang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karsten</namePart><namePart type="family">Witt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Hamel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dieter</namePart><namePart type="family">Weinert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johann</namePart><namePart type="family">Kuhtz‐Buschbeck</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mukaddes</namePart><namePart type="family">Gölge</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Illert</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Physiology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Günther</namePart><namePart type="family">Deuschl</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><description>Correspondence: Neurologische Klinik der, Christian‐Albrechts‐Universität zu Kiel, Niemannsweg 147, 2405 Kiel, 24105 Kiel, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Krack</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-10</dateIssued><dateCaptured encoding="w3cdtf">2002-11-12</dateCaptured><dateValid encoding="w3cdtf">2003-03-06</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">53</extent><extent unit="words">5122</extent></physicalDescription><abstract lang="en">Deep brain stimulation of the subthalamic nucleus (STN‐DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. This suggests that routine STN‐DBS might not be equally effective on all aspects of fine motor functions. © 2003 Movement Disorder Society</abstract><note type="funding">Deutsche Forschungsgemeinsschaft - No. 01KO9811/7; </note><note type="funding">Kompetenznetzwerk Parkinson</note><note type="funding">Kiel University</note><subject lang="en"><genre>Keywords</genre><topic>akinesia</topic><topic>subthalamic nucleus</topic><topic>deep brain stimulation</topic><topic>Parkinson's disease</topic><topic>grip force</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1162</start><end>1169</end><total>7</total></extent></part></relatedItem><identifier type="istex">630F30341523B3232FC289FD145F8E9C28ED775D</identifier><identifier type="DOI">10.1002/mds.10501</identifier><identifier type="ArticleID">MDS10501</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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