Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease
Identifieur interne : 000521 ( Istex/Corpus ); précédent : 000520; suivant : 000522Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease
Auteurs : Takashi Nomura ; Yuichi Inoue ; Hidetaka Mitani ; Ryuzo Kawahara ; Masahiro Miyake ; Kenji NakashimaSource :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
English descriptors
Abstract
To clarify whether visual hallucinations in patients with Parkinson's disease (PD) are related to rapid eye movement (REM) sleep, nocturnal polysomnographic variables were compared between a group with hallucinations (hallucinators, n = 14) and a group without hallucinations (nonhallucinators, n = 8). A multiple sleep latency test (MSLT) was performed on 3 hallucinators, and the content of dreams during daytime REM sleep was investigated. The efficacy of clonazepam, a standard treatment choice for REM sleep behavior disorders, was investigated in 8 hallucinators. Nocturnal polysomnograms of the hallucinators showed a higher amount of stage 1–REM sleep with tonic electromyogram (stage 1–REM) than the nonhallucinators, and the reported occurrences of nocturnal hallucinations corresponded with the periods of stage REM or stage 1–REM in most hallucinators. The frequency of sleep onset REM periods (SOREMP) on the MSLT were pathologically high in the hallucinators, and the content of the dreams during the MSLT period was quite similar to their hallucinations. During clonazepam treatment, the frequency of hallucinatory symptoms decreased in 5 of 8 hallucinators. These results indicate that visual hallucinations in PD are likely to be related to a REM sleep disorder manifested as the appearance of both stage 1–REM during the night and SOREMP in the daytime. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10439
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<keyword xml:id="kwd4">hallucination</keyword>
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<p>To clarify whether visual hallucinations in patients with Parkinson's disease (PD) are related to rapid eye movement (REM) sleep, nocturnal polysomnographic variables were compared between a group with hallucinations (hallucinators, n = 14) and a group without hallucinations (nonhallucinators, n = 8). A multiple sleep latency test (MSLT) was performed on 3 hallucinators, and the content of dreams during daytime REM sleep was investigated. The efficacy of clonazepam, a standard treatment choice for REM sleep behavior disorders, was investigated in 8 hallucinators. Nocturnal polysomnograms of the hallucinators showed a higher amount of stage 1–REM sleep with tonic electromyogram (stage 1–REM) than the nonhallucinators, and the reported occurrences of nocturnal hallucinations corresponded with the periods of stage REM or stage 1–REM in most hallucinators. The frequency of sleep onset REM periods (SOREMP) on the MSLT were pathologically high in the hallucinators, and the content of the dreams during the MSLT period was quite similar to their hallucinations. During clonazepam treatment, the frequency of hallucinatory symptoms decreased in 5 of 8 hallucinators. These results indicate that visual hallucinations in PD are likely to be related to a REM sleep disorder manifested as the appearance of both stage 1–REM during the night and SOREMP in the daytime. © 2003 Movement Disorder Society</p>
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<!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease</title>
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<titleInfo type="abbreviated" lang="en"><title>Visual Hallucinations as RBD in PD</title>
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<name type="personal"><namePart type="given">Takashi</namePart>
<namePart type="family">Nomura</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago, Japan</affiliation>
<description>Correspondence: Department of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine, 36‐1 Nishimachi, Yonago 683‐8504, Japan</description>
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<name type="personal"><namePart type="given">Yuichi</namePart>
<namePart type="family">Inoue</namePart>
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<affiliation>Department of Psychiatry, Juntendo University School of Medicine, Hongo, Tokyo, Japan</affiliation>
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<name type="personal"><namePart type="given">Hidetaka</namePart>
<namePart type="family">Mitani</namePart>
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<affiliation>Department of Psychiatry, Tottori University, Faculty of Medicine, Yonago, Japan</affiliation>
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<name type="personal"><namePart type="given">Ryuzo</namePart>
<namePart type="family">Kawahara</namePart>
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<affiliation>Department of Psychiatry, Tottori University, Faculty of Medicine, Yonago, Japan</affiliation>
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<name type="personal"><namePart type="given">Masahiro</namePart>
<namePart type="family">Miyake</namePart>
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<affiliation>Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago, Japan</affiliation>
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<name type="personal"><namePart type="given">Kenji</namePart>
<namePart type="family">Nakashima</namePart>
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<affiliation>Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago, Japan</affiliation>
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<abstract lang="en">To clarify whether visual hallucinations in patients with Parkinson's disease (PD) are related to rapid eye movement (REM) sleep, nocturnal polysomnographic variables were compared between a group with hallucinations (hallucinators, n = 14) and a group without hallucinations (nonhallucinators, n = 8). A multiple sleep latency test (MSLT) was performed on 3 hallucinators, and the content of dreams during daytime REM sleep was investigated. The efficacy of clonazepam, a standard treatment choice for REM sleep behavior disorders, was investigated in 8 hallucinators. Nocturnal polysomnograms of the hallucinators showed a higher amount of stage 1–REM sleep with tonic electromyogram (stage 1–REM) than the nonhallucinators, and the reported occurrences of nocturnal hallucinations corresponded with the periods of stage REM or stage 1–REM in most hallucinators. The frequency of sleep onset REM periods (SOREMP) on the MSLT were pathologically high in the hallucinators, and the content of the dreams during the MSLT period was quite similar to their hallucinations. During clonazepam treatment, the frequency of hallucinatory symptoms decreased in 5 of 8 hallucinators. These results indicate that visual hallucinations in PD are likely to be related to a REM sleep disorder manifested as the appearance of both stage 1–REM during the night and SOREMP in the daytime. © 2003 Movement Disorder Society</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>REM sleep disorder</topic>
<topic>polysomnography</topic>
<topic>clonazepam</topic>
<topic>hallucination</topic>
<topic>Parkinson's disease</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
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