Depression comorbidity in spinocerebellar ataxia
Identifieur interne : 000522 ( Istex/Corpus ); précédent : 000521; suivant : 000523Depression comorbidity in spinocerebellar ataxia
Auteurs : Tanja Schmitz-Hübsch ; Mathieu Coudert ; Sophie Tezenas Du Montcel ; Paola Giunti ; Robyn Labrum ; Alexandra Dürr ; Pascale Ribai ; Perrine Charles ; Christoph Linnemann ; Ludger Schöls ; Maryla Rakowicz ; Rafal Rola ; Elszbieta Zdzienicka ; Roberto Fancellu ; Caterina Mariotti ; Lazlo Baliko ; Bela Melegh ; Alessandro Filla ; Elena Salvatore ; Bart P. C. Van De Warrenburg ; Sandra Szymanski ; Jon Infante ; Dagmar Timmann ; Sylvia Boesch ; Chantal Depondt ; Jun-Suk Kang ; Jörg B. Schulz ; Thomas Klopstock ; Nicole Lossnitzer ; Bernd Löwe ; Caroline Frick ; Daniela Rottl Nder ; Thomas E. Schlaepfer ; Thomas KlockgetherSource :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
English descriptors
Abstract
This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23698
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sort="Tezenas Du Montcel, Sophie" uniqKey="Tezenas Du Montcel S" first="Sophie" last="Tezenas Du Montcel">Sophie Tezenas Du Montcel</name><affiliation><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation><mods:affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Labrum, Robyn" sort="Labrum, Robyn" uniqKey="Labrum R" first="Robyn" last="Labrum">Robyn Labrum</name><affiliation><mods:affiliation>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Ribai, Pascale" sort="Ribai, Pascale" uniqKey="Ribai P" first="Pascale" last="Ribai">Pascale Ribai</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Charles, Perrine" sort="Charles, Perrine" uniqKey="Charles P" first="Perrine" last="Charles">Perrine Charles</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Linnemann, Christoph" sort="Linnemann, Christoph" uniqKey="Linnemann C" first="Christoph" last="Linnemann">Christoph Linnemann</name><affiliation><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation><mods:affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation><mods:affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation><mods:affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation><mods:affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation><mods:affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation><mods:affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</mods:affiliation></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation><mods:affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</mods:affiliation></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation><mods:affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><mods:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation><mods:affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation><mods:affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation><mods:affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation><mods:affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name><affiliation><mods:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23698</idno><idno type="url">https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000522</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Depression comorbidity in spinocerebellar ataxia</title><author><name sortKey="Schmitz Bsch, Tanja" sort="Schmitz Bsch, Tanja" uniqKey="Schmitz Bsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Coudert, Mathieu" sort="Coudert, Mathieu" uniqKey="Coudert M" first="Mathieu" last="Coudert">Mathieu Coudert</name><affiliation><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Tezenas Du Montcel, Sophie" sort="Tezenas Du Montcel, Sophie" uniqKey="Tezenas Du Montcel S" first="Sophie" last="Tezenas Du Montcel">Sophie Tezenas Du Montcel</name><affiliation><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation><mods:affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Labrum, Robyn" sort="Labrum, Robyn" uniqKey="Labrum R" first="Robyn" last="Labrum">Robyn Labrum</name><affiliation><mods:affiliation>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Ribai, Pascale" sort="Ribai, Pascale" uniqKey="Ribai P" first="Pascale" last="Ribai">Pascale Ribai</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Charles, Perrine" sort="Charles, Perrine" uniqKey="Charles P" first="Perrine" last="Charles">Perrine Charles</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Linnemann, Christoph" sort="Linnemann, Christoph" uniqKey="Linnemann C" first="Christoph" last="Linnemann">Christoph Linnemann</name><affiliation><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation><mods:affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation><mods:affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation><mods:affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation><mods:affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation><mods:affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation><mods:affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</mods:affiliation></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation><mods:affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</mods:affiliation></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation><mods:affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><mods:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation><mods:affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation><mods:affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation><mods:affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation><mods:affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name><affiliation><mods:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name><affiliation><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="870">870</biblScope><biblScope unit="page" to="876">876</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</idno><idno type="DOI">10.1002/mds.23698</idno><idno type="ArticleID">MDS23698</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cerebellum</term><term>depression</term><term>prevalence studies</term><term>spinocerebellar ataxia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Tanja Schmitz‐Hübsch MD</name><affiliations><json:string>Department of Neurology, University Hospital of Bonn, Bonn, Germany</json:string></affiliations></json:item><json:item><name>Mathieu Coudert</name><affiliations><json:string>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</json:string><json:string>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</json:string></affiliations></json:item><json:item><name>Sophie Tezenas du Montcel MD, PhD</name><affiliations><json:string>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</json:string><json:string>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</json:string></affiliations></json:item><json:item><name>Paola Giunti MD</name><affiliations><json:string>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Robyn Labrum PhD</name><affiliations><json:string>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Alexandra Dürr MD, PhD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</json:string><json:string>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</json:string></affiliations></json:item><json:item><name>Pascale Ribai MD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</json:string><json:string>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</json:string></affiliations></json:item><json:item><name>Perrine Charles MD, PhD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</json:string><json:string>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</json:string></affiliations></json:item><json:item><name>Christoph Linnemann MD</name><affiliations><json:string>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Ludger Schöls MD</name><affiliations><json:string>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Maryla Rakowicz MD, PhD</name><affiliations><json:string>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</json:string></affiliations></json:item><json:item><name>Rafal Rola MD, PhD</name><affiliations><json:string>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</json:string></affiliations></json:item><json:item><name>Elszbieta Zdzienicka MD</name><affiliations><json:string>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</json:string></affiliations></json:item><json:item><name>Roberto Fancellu MD</name><affiliations><json:string>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</json:string></affiliations></json:item><json:item><name>Caterina Mariotti MD</name><affiliations><json:string>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</json:string></affiliations></json:item><json:item><name>Lazlo Baliko MD</name><affiliations><json:string>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</json:string></affiliations></json:item><json:item><name>Bela Melegh MD, PhD</name><affiliations><json:string>Department of Medical Genetics and Child Development, University of Pécs, Hungary</json:string></affiliations></json:item><json:item><name>Alessandro Filla MD</name><affiliations><json:string>Department of Neurology, University of Naples, Naples, Italy</json:string></affiliations></json:item><json:item><name>Elena Salvatore MD, PhD</name><affiliations><json:string>Department of Neurology, University of Naples, Naples, Italy</json:string></affiliations></json:item><json:item><name>Bart P.C. van de Warrenburg MD, PhD</name><affiliations><json:string>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Sandra Szymanski MD</name><affiliations><json:string>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</json:string></affiliations></json:item><json:item><name>Jon Infante MD</name><affiliations><json:string>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</json:string></affiliations></json:item><json:item><name>Dagmar Timmann MD</name><affiliations><json:string>Department of Neurology, University Hospital of Essen, Essen, Germany</json:string></affiliations></json:item><json:item><name>Sylvia Boesch MD</name><affiliations><json:string>Department of Neurology, University of Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Chantal Depondt MD, PhD</name><affiliations><json:string>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Jun‐Suk Kang MD</name><affiliations><json:string>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</json:string></affiliations></json:item><json:item><name>Jörg B. Schulz MD</name><affiliations><json:string>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</json:string></affiliations></json:item><json:item><name>Thomas Klopstock MD</name><affiliations><json:string>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</json:string></affiliations></json:item><json:item><name>Nicole Lossnitzer PhD</name><affiliations><json:string>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</json:string></affiliations></json:item><json:item><name>Bernd Löwe MD</name><affiliations><json:string>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</json:string></affiliations></json:item><json:item><name>Caroline Frick</name><affiliations><json:string>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</json:string></affiliations></json:item><json:item><name>Daniela Rottländer</name><affiliations><json:string>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</json:string></affiliations></json:item><json:item><name>Thomas E. Schlaepfer MD</name><affiliations><json:string>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</json:string><json:string>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</json:string></affiliations></json:item><json:item><name>Thomas Klockgether MD</name><affiliations><json:string>Department of Neurology, University Hospital of Bonn, Bonn, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>spinocerebellar ataxia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebellum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prevalence studies</value></json:item></subject><language><json:string>eng</json:string></language><abstract>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.508</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1674</abstractCharCount><pdfWordCount>4640</pdfWordCount><pdfCharCount>31508</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>239</abstractWordCount></qualityIndicators><title>Depression comorbidity in spinocerebellar ataxia</title><genre><json:string>Serial article</json:string></genre><host><volume>26</volume><pages><total>7</total><last>876</last><first>870</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23698</json:string></doi><id>50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Depression comorbidity in spinocerebellar ataxia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2011</date></publicationStmt><notesStmt><note>Author Roles and Disclosures</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*The study was supported by grant EUROSCA/LSHM‐CT‐2004‐503304 from the European Union (to T. Schmitz‐Hübsch, S. Tezenas du Montcel, P. Giunti, L. Schöls, M. Rakowicz, R. Rola, E. Zdzienicka, R. Fancellu, C. Mariotti, B. Melegh, A. Filla, B.P.C. van de Warrenburg, J. Infante, S. Boesch, C. Depondt, J.‐S. Kang, J. Schulz, T. Klockgether), grant GeneMove/01 GM 0503 from the German Ministry of Education and Research (to D. Timmann, L. Schöls, J.‐S. Kang, J. Schulz, T. Klopstock, T. Klockgether), and grant 3 PO5B 019 24 from the Polish Ministry of Scientific Research and Information Technology (to R. Rola).</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Depression comorbidity in spinocerebellar ataxia</title><author><persName><forename type="first">Tanja</forename><surname>Schmitz‐Hübsch</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, University Hospital of Bonn, Sigmund‐Freud‐Str. 25, D‐53105 Bonn, Germany</p></note><affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</affiliation></author><author><persName><forename type="first">Mathieu</forename><surname>Coudert</surname></persName><affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</affiliation><affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</affiliation></author><author><persName><forename type="first">Sophie</forename><surname>Tezenas du Montcel</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</affiliation><affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</affiliation></author><author><persName><forename type="first">Paola</forename><surname>Giunti</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom</affiliation></author><author><persName><forename type="first">Robyn</forename><surname>Labrum</surname><roleName type="degree">PhD</roleName></persName><affiliation>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London, United Kingdom</affiliation></author><author><persName><forename type="first">Alexandra</forename><surname>Dürr</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</affiliation></author><author><persName><forename type="first">Pascale</forename><surname>Ribai</surname><roleName type="degree">MD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</affiliation></author><author><persName><forename type="first">Perrine</forename><surname>Charles</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</affiliation></author><author><persName><forename type="first">Christoph</forename><surname>Linnemann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</affiliation></author><author><persName><forename type="first">Ludger</forename><surname>Schöls</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</affiliation></author><author><persName><forename type="first">Maryla</forename><surname>Rakowicz</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation></author><author><persName><forename type="first">Rafal</forename><surname>Rola</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation></author><author><persName><forename type="first">Elszbieta</forename><surname>Zdzienicka</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Fancellu</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</affiliation></author><author><persName><forename type="first">Caterina</forename><surname>Mariotti</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</affiliation></author><author><persName><forename type="first">Lazlo</forename><surname>Baliko</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</affiliation></author><author><persName><forename type="first">Bela</forename><surname>Melegh</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</affiliation></author><author><persName><forename type="first">Alessandro</forename><surname>Filla</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Naples, Naples, Italy</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Salvatore</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, University of Naples, Naples, Italy</affiliation></author><author><persName><forename type="first">Bart P.C.</forename><surname>van de Warrenburg</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</affiliation></author><author><persName><forename type="first">Sandra</forename><surname>Szymanski</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</affiliation></author><author><persName><forename type="first">Jon</forename><surname>Infante</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</affiliation></author><author><persName><forename type="first">Dagmar</forename><surname>Timmann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</affiliation></author><author><persName><forename type="first">Sylvia</forename><surname>Boesch</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Chantal</forename><surname>Depondt</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</affiliation></author><author><persName><forename type="first">Jun‐Suk</forename><surname>Kang</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</affiliation></author><author><persName><forename type="first">Jörg B.</forename><surname>Schulz</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</affiliation></author><author><persName><forename type="first">Thomas</forename><surname>Klopstock</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</affiliation></author><author><persName><forename type="first">Nicole</forename><surname>Lossnitzer</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</affiliation></author><author><persName><forename type="first">Bernd</forename><surname>Löwe</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</affiliation></author><author><persName><forename type="first">Caroline</forename><surname>Frick</surname></persName><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Rottländer</surname></persName><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation></author><author><persName><forename type="first">Thomas E.</forename><surname>Schlaepfer</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation><affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</affiliation></author><author><persName><forename type="first">Thomas</forename><surname>Klockgether</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>spinocerebellar ataxia</term></item><item><term>depression</term></item><item><term>cerebellum</term></item><item><term>prevalence studies</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07-16">Received</change><change when="2011-02-07">Registration</change><change when="2011-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Stroke, County Hospital, Veszprém, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="HU" type="organization"><unparsedAffiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, University of Naples, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af18" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af19" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af20" countryCode="AT" type="organization"><unparsedAffiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af21" countryCode="BE" type="organization"><unparsedAffiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="af22" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af23" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af24" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af25" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af26" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af27" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af28" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">spinocerebellar ataxia</keyword><keyword xml:id="kwd2">depression</keyword><keyword xml:id="kwd3">cerebellum</keyword><keyword xml:id="kwd4">prevalence studies</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23698:MDS_23698_sm_authorroles"></mediaResource><caption>Author Roles and Disclosures</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn4"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn5"><p>The study was supported by grant EUROSCA/LSHM‐CT‐2004‐503304 from the European Union (to T. Schmitz‐Hübsch, S. Tezenas du Montcel, P. Giunti, L. Schöls, M. Rakowicz, R. Rola, E. Zdzienicka, R. Fancellu, C. Mariotti, B. Melegh, A. Filla, B.P.C. van de Warrenburg, J. Infante, S. Boesch, C. Depondt, J.‐S. Kang, J. Schulz, T. Klockgether), grant GeneMove/01 GM 0503 from the German Ministry of Education and Research (to D. Timmann, L. Schöls, J.‐S. Kang, J. Schulz, T. Klopstock, T. Klockgether), and grant 3 PO5B 019 24 from the Polish Ministry of Scientific Research and Information Technology (to R. Rola).</p></note><note xml:id="fn6"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Depression comorbidity in spinocerebellar ataxia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Depression In SCA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Depression comorbidity in spinocerebellar ataxia</title></titleInfo><name type="personal"><namePart type="given">Tanja</namePart><namePart type="family">Schmitz‐Hübsch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</affiliation><description>Correspondence: Department of Neurology, University Hospital of Bonn, Sigmund‐Freud‐Str. 25, D‐53105 Bonn, Germany</description><role><roleTerm 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Cytogenetics, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascale</namePart><namePart type="family">Ribai</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Perrine</namePart><namePart type="family">Charles</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Linnemann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ludger</namePart><namePart type="family">Schöls</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maryla</namePart><namePart type="family">Rakowicz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rafal</namePart><namePart type="family">Rola</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elszbieta</namePart><namePart type="family">Zdzienicka</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Fancellu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caterina</namePart><namePart type="family">Mariotti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lazlo</namePart><namePart type="family">Baliko</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bela</namePart><namePart type="family">Melegh</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Filla</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Naples, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Salvatore</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University of Naples, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bart P.C.</namePart><namePart type="family">van de Warrenburg</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandra</namePart><namePart type="family">Szymanski</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jon</namePart><namePart type="family">Infante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dagmar</namePart><namePart type="family">Timmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvia</namePart><namePart type="family">Boesch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chantal</namePart><namePart type="family">Depondt</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jun‐Suk</namePart><namePart type="family">Kang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jörg B.</namePart><namePart type="family">Schulz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Klopstock</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicole</namePart><namePart type="family">Lossnitzer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernd</namePart><namePart type="family">Löwe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caroline</namePart><namePart type="family">Frick</namePart><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Rottländer</namePart><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas E.</namePart><namePart type="family">Schlaepfer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</affiliation><affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Klockgether</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-04</dateIssued><dateCaptured encoding="w3cdtf">2010-07-16</dateCaptured><dateValid encoding="w3cdtf">2011-02-07</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">41</extent><extent unit="words">6801</extent></physicalDescription><abstract lang="en">This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</abstract><note type="additional physical form">Author Roles and Disclosures</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*The study was supported by grant EUROSCA/LSHM‐CT‐2004‐503304 from the European Union (to T. Schmitz‐Hübsch, S. Tezenas du Montcel, P. Giunti, L. Schöls, M. Rakowicz, R. Rola, E. Zdzienicka, R. Fancellu, C. Mariotti, B. Melegh, A. Filla, B.P.C. van de Warrenburg, J. Infante, S. Boesch, C. Depondt, J.‐S. Kang, J. Schulz, T. Klockgether), grant GeneMove/01 GM 0503 from the German Ministry of Education and Research (to D. Timmann, L. Schöls, J.‐S. Kang, J. Schulz, T. Klopstock, T. Klockgether), and grant 3 PO5B 019 24 from the Polish Ministry of Scientific Research and Information Technology (to R. Rola).</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>spinocerebellar ataxia</topic><topic>depression</topic><topic>cerebellum</topic><topic>prevalence studies</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>870</start><end>876</end><total>7</total></extent></part></relatedItem><identifier type="istex">50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</identifier><identifier type="DOI">10.1002/mds.23698</identifier><identifier type="ArticleID">MDS23698</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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