Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.
Identifieur interne : 000045 ( Hal/Curation ); précédent : 000044; suivant : 000046Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.
Auteurs : Marwan Hariz [Royaume-Uni] ; Stig Rehncrona [Suède] ; Niall Quinn [Royaume-Uni] ; Johannes Speelman [Pays-Bas] ; Carin Wensing [Pays-Bas] ; Multicentre Advanced Parkinson'S Disease Deep Brain Stimulation GroupSource :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Abstract
Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.
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DOI: 10.1002/mds.21888
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type="datePub">2008-02-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.</title><author role="aut"><persName><forename type="first">Marwan</forename><forename type="middle">I.</forename><surname>Hariz</surname></persName><email></email><idno type="halauthor">410284</idno><affiliation ref="#struct-95900"></affiliation><affiliation ref="#struct-95901"></affiliation></author><author role="aut"><persName><forename type="first">Stig</forename><surname>Rehncrona</surname></persName><email></email><idno type="halauthor">410285</idno><affiliation ref="#struct-95902"></affiliation></author><author role="aut"><persName><forename type="first">Niall</forename><forename type="middle">P.</forename><surname>Quinn</surname></persName><email></email><idno type="halauthor">410286</idno><affiliation ref="#struct-95900"></affiliation></author><author role="aut"><persName><forename type="first">Johannes</forename><forename type="middle">D.</forename><surname>Speelman</surname></persName><email></email><idno type="halauthor">410287</idno><affiliation ref="#struct-95903"></affiliation></author><author role="aut"><persName><forename type="first">Carin</forename><surname>Wensing</surname></persName><email></email><idno type="halauthor">410288</idno><affiliation ref="#struct-95904"></affiliation></author><author role="aut"><persName><forename type="first">Multicentre Advanced Parkinson'S Disease</forename><surname>Deep Brain Stimulation Group</surname></persName><email></email><idno type="halauthor">410289</idno></author><editor role="depositor"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2009-06-04 10:18:17</date><date type="whenModified">2009-06-12 15:08:17</date><date type="whenReleased">2009-06-12 15:08:17</date><date type="whenProduced">2008-02-15</date></edition><respStmt><resp>contributor</resp><name key="140382"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00391487</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00391487</idno><idno type="halBibtex">hariz:inserm-00391487</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2008, 23 (3), pp.416-21. <10.1002/mds.21888></idno><idno type="halRef">Movement Disorders, Wiley, 2008, 23 (3), pp.416-21. <10.1002/mds.21888></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.</title><author role="aut"><persName><forename type="first">Marwan</forename><forename type="middle">I.</forename><surname>Hariz</surname></persName><idno type="halAuthorId">410284</idno><affiliation ref="#struct-95900"></affiliation><affiliation ref="#struct-95901"></affiliation></author><author role="aut"><persName><forename type="first">Stig</forename><surname>Rehncrona</surname></persName><idno type="halAuthorId">410285</idno><affiliation ref="#struct-95902"></affiliation></author><author role="aut"><persName><forename type="first">Niall</forename><forename type="middle">P.</forename><surname>Quinn</surname></persName><idno type="halAuthorId">410286</idno><affiliation ref="#struct-95900"></affiliation></author><author role="aut"><persName><forename type="first">Johannes</forename><forename type="middle">D.</forename><surname>Speelman</surname></persName><idno type="halAuthorId">410287</idno><affiliation ref="#struct-95903"></affiliation></author><author role="aut"><persName><forename type="first">Carin</forename><surname>Wensing</surname></persName><idno type="halAuthorId">410288</idno><affiliation ref="#struct-95904"></affiliation></author><author role="aut"><persName><forename type="first">Multicentre Advanced Parkinson'S Disease</forename><surname>Deep Brain Stimulation Group</surname></persName><idno type="halAuthorId">410289</idno></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="pp">416-21</biblScope><date type="datePub">2008-02-15</date></imprint></monogr><idno type="doi">10.1002/mds.21888</idno><idno type="pubmed">18067188</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Case-Control Studies</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="mesh">Neurologic Examination</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Subthalamic Nucleus</classCode><classCode scheme="mesh">Deep Brain Stimulation</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Gait Disorders, Neurologic</classCode><classCode scheme="mesh">Globus Pallidus</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Longitudinal Studies</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Mental Disorders</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.</abstract><particDesc><org type="consortium">Collaboration</org></particDesc></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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