Chemical exposures and Parkinson's disease: a population-based case-control study.
Identifieur interne : 000012 ( Hal/Curation ); précédent : 000011; suivant : 000013Chemical exposures and Parkinson's disease: a population-based case-control study.
Auteurs : Roberta Frigerio [États-Unis] ; Kevin Sanft [États-Unis] ; Brandon Grossardt [États-Unis] ; Brett Peterson [États-Unis] ; Alexis Elbaz [France] ; James Bower [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Mariza De Andrade [États-Unis] ; Demetrius Maraganore [États-Unis] ; Walter Rocca [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Abstract
The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.
Url:
DOI: 10.1002/mds.21009
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<front><div type="abstract" xml:lang="en">The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.</div>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Chemical exposures and Parkinson's disease: a population-based case-control study.</title>
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<author role="aut"><persName><forename type="first">Mariza</forename>
<surname>De Andrade</surname>
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<author role="aut"><persName><forename type="first">Demetrius</forename>
<forename type="middle">M.</forename>
<surname>Maraganore</surname>
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<author role="crp"><persName><forename type="first">Walter</forename>
<forename type="middle">A.</forename>
<surname>Rocca</surname>
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<email>rocca@mayo.edu</email>
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<title level="j">Movement Disorders</title>
<imprint><publisher>Wiley</publisher>
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<biblScope unit="issue">10</biblScope>
<biblScope unit="pp">1688-92</biblScope>
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<textClass><keywords scheme="author"><term xml:lang="es">chemical exposures</term>
<term xml:lang="es">pesticides</term>
<term xml:lang="es">Parkinson's disease</term>
<term xml:lang="es">case– control study</term>
<term xml:lang="es">sex differences</term>
</keywords>
<classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="mesh">Minnesota</classCode>
<classCode scheme="mesh">Parkinson Disease</classCode>
<classCode scheme="mesh">Parkinsonian Disorders</classCode>
<classCode scheme="mesh">Pesticides</classCode>
<classCode scheme="mesh">Risk Factors</classCode>
<classCode scheme="mesh">Smoking</classCode>
<classCode scheme="mesh">Aged, 80 and over</classCode>
<classCode scheme="mesh">Agriculture</classCode>
<classCode scheme="mesh">Case-Control Studies</classCode>
<classCode scheme="mesh">Causality</classCode>
<classCode scheme="mesh">Educational Status</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Health Surveys</classCode>
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<abstract xml:lang="en">The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.</abstract>
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