Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure.
Identifieur interne : 000013 ( Hal/Curation ); précédent : 000012; suivant : 000014Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure.
Auteurs : Jean-Philippe Galanaud [France] ; Alexis Elbaz [France] ; Jacqueline Clavel [France] ; Jean-Sébastien Vidal [France] ; Jean-René Corrèze [France] ; Annick Alpérovitch [France] ; Christophe Tzourio [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-02.
English descriptors
Abstract
Epidemiological studies have been consistent in showing that cigarette smoking is inversely associated with Parkinson's disease (PD), whereas pesticide use is positively associated with PD. However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case-control study was carried out among subjects enrolled in the Mutualite Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in-person interviews. Pesticide exposure was assessed using a case-by-case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4-0.9). The strength of this association increased with the number of pack-years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3-0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides.
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DOI: 10.1002/mds.20307
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However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case-control study was carried out among subjects enrolled in the Mutualite Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in-person interviews. Pesticide exposure was assessed using a case-by-case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4-0.9). The strength of this association increased with the number of pack-years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3-0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure.</title><author role="aut"><persName><forename type="first">Jean-Philippe</forename><surname>Galanaud</surname></persName><email></email><idno type="halauthor">214236</idno><affiliation ref="#struct-42754"></affiliation></author><author role="crp"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halauthor">214201</idno><affiliation ref="#struct-42754"></affiliation></author><author role="aut"><persName><forename type="first">Jacqueline</forename><surname>Clavel</surname></persName><email></email><idno type="halauthor">112257</idno><affiliation ref="#struct-17135"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Sébastien</forename><surname>Vidal</surname></persName><email></email><idno type="halauthor">214237</idno><affiliation ref="#struct-16622"></affiliation></author><author role="aut"><persName><forename type="first">Jean-René</forename><surname>Corrèze</surname></persName><email></email><idno type="halauthor">214238</idno><affiliation ref="#struct-45585"></affiliation></author><author role="aut"><persName><forename type="first">Annick</forename><surname>Alpérovitch</surname></persName><email></email><idno type="halauthor">154461</idno><affiliation ref="#struct-42754"></affiliation></author><author role="aut"><persName><forename type="first">Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email><idno type="halauthor">183676</idno><affiliation ref="#struct-42754"></affiliation></author><editor role="depositor"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2007-10-05 12:56:34</date><date type="whenModified">2015-01-19 11:49:49</date><date type="whenReleased">2007-10-05 13:55:04</date><date type="whenProduced">2005-02</date><date type="whenEndEmbargoed">9999-12-31</date><ref type="file" target="http://www.hal.inserm.fr/inserm-00177072/document"><date notBefore="9999-12-31"></date></ref><ref type="file" n="1" target="http://www.hal.inserm.fr/inserm-00177072/file/4.pdf"><date notBefore="9999-12-31"></date></ref></edition><respStmt><resp>contributor</resp><name key="118702"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00177072</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00177072</idno><idno type="halBibtex">galanaud:inserm-00177072</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2005, 20 (2), pp.181-9. <10.1002/mds.20307></idno><idno type="halRef">Movement Disorders, Wiley, 2005, 20 (2), pp.181-9. <10.1002/mds.20307></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="IFR69" p="INSERM">IFR69</idno><idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno><idno type="stamp" n="APHP" p="INSERM">AP-HP</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure.</title><author role="aut"><persName><forename type="first">Jean-Philippe</forename><surname>Galanaud</surname></persName><idno type="halAuthorId">214236</idno><affiliation ref="#struct-42754"></affiliation></author><author role="crp"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halAuthorId">214201</idno><affiliation ref="#struct-42754"></affiliation></author><author role="aut"><persName><forename type="first">Jacqueline</forename><surname>Clavel</surname></persName><idno type="halAuthorId">112257</idno><affiliation ref="#struct-17135"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Sébastien</forename><surname>Vidal</surname></persName><idno type="halAuthorId">214237</idno><affiliation ref="#struct-16622"></affiliation></author><author role="aut"><persName><forename type="first">Jean-René</forename><surname>Corrèze</surname></persName><idno type="halAuthorId">214238</idno><affiliation ref="#struct-45585"></affiliation></author><author role="aut"><persName><forename type="first">Annick</forename><surname>Alpérovitch</surname></persName><idno type="halAuthorId">154461</idno><affiliation ref="#struct-42754"></affiliation></author><author role="aut"><persName><forename type="first">Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email><idno type="halAuthorId">183676</idno><affiliation ref="#struct-42754"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">20</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="pp">181-9</biblScope><date type="datePub">2005-02</date></imprint></monogr><idno type="doi">10.1002/mds.20307</idno><idno type="pubmed">15468111</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Parkinson's disease</term><term xml:lang="en">smoking</term><term xml:lang="en">case– control</term><term xml:lang="en">epidemiology</term></keywords><classCode scheme="mesh">Adult</classCode><classCode scheme="mesh">Age of Onset</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Pesticides</classCode><classCode scheme="mesh">Prevalence</classCode><classCode scheme="mesh">Risk Factors</classCode><classCode scheme="mesh">Sex Factors</classCode><classCode scheme="mesh">Smoking</classCode><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Case-Control Studies</classCode><classCode scheme="mesh">Confidence Intervals</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="mesh">Odds Ratio</classCode><classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode><classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Epidemiological studies have been consistent in showing that cigarette smoking is inversely associated with Parkinson's disease (PD), whereas pesticide use is positively associated with PD. However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case-control study was carried out among subjects enrolled in the Mutualite Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in-person interviews. Pesticide exposure was assessed using a case-by-case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4-0.9). The strength of this association increased with the number of pack-years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3-0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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