Chemical exposures and Parkinson's disease: a population-based case-control study.
Identifieur interne : 000012 ( Hal/Corpus ); précédent : 000011; suivant : 000013Chemical exposures and Parkinson's disease: a population-based case-control study.
Auteurs : Roberta Frigerio ; Kevin Sanft ; Brandon Grossardt ; Brett Peterson ; Alexis Elbaz ; James Bower ; J. Eric Ahlskog ; Mariza De Andrade ; Demetrius Maraganore ; Walter RoccaSource :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Abstract
The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.
Url:
DOI: 10.1002/mds.21009
Links to Exploration step
Hal:inserm-00180017Le document en format XML
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Eric Ahlskog</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-45572" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="US"></country></address></desc><listRelation><relation active="#struct-310852" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310852" type="direct"><org type="institution" xml:id="struct-310852" status="INCOMING"><orgName>Mayo Clinic College of Medicine, Rochester, Minnesota, USA</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-46399" status="INCOMING"><orgName>Division of Biostatistics, Department of Health Sciences Research</orgName><desc><address><country key="US"></country></address></desc><listRelation><relation active="#struct-310989" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310989" type="direct"><org type="institution" xml:id="struct-310989" status="INCOMING"><orgName>Mayo College of Medicine, Rochester</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius" sort="Maraganore, Demetrius" uniqKey="Maraganore D" first="Demetrius" last="Maraganore">Demetrius Maraganore</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-45572" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="US"></country></address></desc><listRelation><relation active="#struct-310852" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310852" type="direct"><org type="institution" xml:id="struct-310852" status="INCOMING"><orgName>Mayo Clinic College of Medicine, Rochester, Minnesota, USA</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rocca, Walter" sort="Rocca, Walter" uniqKey="Rocca W" first="Walter" last="Rocca">Walter Rocca</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-46397" status="INCOMING"><orgName>Division of Epidemiology, Departments of Health Sciences Research</orgName><desc><address><country key="US"></country></address></desc><listRelation><relation active="#struct-310852" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310852" type="direct"><org type="institution" xml:id="struct-310852" status="INCOMING"><orgName>Mayo Clinic College of Medicine, Rochester, Minnesota, USA</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1002/mds.21009</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2006-10</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="es"><term>Parkinson's disease</term><term>case– control study</term><term>chemical exposures</term><term>pesticides</term><term>sex differences</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Chemical exposures and Parkinson's disease: a population-based case-control study.</title><author role="aut"><persName><forename type="first">Roberta</forename><surname>Frigerio</surname></persName><email></email><idno type="halauthor">214232</idno><affiliation ref="#struct-46397"></affiliation></author><author role="aut"><persName><forename type="first">Kevin</forename><forename type="middle">R.</forename><surname>Sanft</surname></persName><email></email><idno type="halauthor">214233</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Brandon</forename><forename type="middle">R.</forename><surname>Grossardt</surname></persName><email></email><idno type="halauthor">214234</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Brett</forename><forename type="middle">J.</forename><surname>Peterson</surname></persName><email></email><idno type="halauthor">214214</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halauthor">214201</idno><affiliation ref="#struct-3066"></affiliation></author><author role="aut"><persName><forename type="first">James</forename><forename type="middle">H.</forename><surname>Bower</surname></persName><email></email><idno type="halauthor">214216</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">J. Eric</forename><surname>Ahlskog</surname></persName><email></email><idno type="halauthor">214219</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Mariza</forename><surname>De Andrade</surname></persName><email></email><idno type="halauthor">214235</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Demetrius</forename><forename type="middle">M.</forename><surname>Maraganore</surname></persName><email></email><idno type="halauthor">214217</idno><affiliation ref="#struct-45572"></affiliation></author><author role="crp"><persName><forename type="first">Walter</forename><forename type="middle">A.</forename><surname>Rocca</surname></persName><email>rocca@mayo.edu</email><idno type="halauthor">214220</idno><affiliation ref="#struct-46397"></affiliation><affiliation ref="#struct-45572"></affiliation></author><editor role="depositor"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2007-10-17 14:39:15</date><date type="whenModified">2015-01-19 11:49:49</date><date type="whenReleased">2007-10-17 14:58:41</date><date type="whenProduced">2006-10</date><date type="whenEndEmbargoed">9999-12-31</date><ref type="file" target="http://www.hal.inserm.fr/inserm-00180017/document"><date notBefore="9999-12-31"></date></ref><ref type="file" n="1" target="http://www.hal.inserm.fr/inserm-00180017/file/7.pdf"><date notBefore="9999-12-31"></date></ref></edition><respStmt><resp>contributor</resp><name key="118702"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00180017</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00180017</idno><idno type="halBibtex">frigerio:inserm-00180017</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2006, 21 (10), pp.1688-92. <10.1002/mds.21009></idno><idno type="halRef">Movement Disorders, Wiley, 2006, 21 (10), pp.1688-92. <10.1002/mds.21009></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chemical exposures and Parkinson's disease: a population-based case-control study.</title><author role="aut"><persName><forename type="first">Roberta</forename><surname>Frigerio</surname></persName><idno type="halAuthorId">214232</idno><affiliation ref="#struct-46397"></affiliation></author><author role="aut"><persName><forename type="first">Kevin</forename><forename type="middle">R.</forename><surname>Sanft</surname></persName><idno type="halAuthorId">214233</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Brandon</forename><forename type="middle">R.</forename><surname>Grossardt</surname></persName><idno type="halAuthorId">214234</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Brett</forename><forename type="middle">J.</forename><surname>Peterson</surname></persName><idno type="halAuthorId">214214</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halAuthorId">214201</idno><affiliation ref="#struct-3066"></affiliation></author><author role="aut"><persName><forename type="first">James</forename><forename type="middle">H.</forename><surname>Bower</surname></persName><idno type="halAuthorId">214216</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">J. Eric</forename><surname>Ahlskog</surname></persName><idno type="halAuthorId">214219</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Mariza</forename><surname>De Andrade</surname></persName><idno type="halAuthorId">214235</idno><affiliation ref="#struct-46399"></affiliation></author><author role="aut"><persName><forename type="first">Demetrius</forename><forename type="middle">M.</forename><surname>Maraganore</surname></persName><idno type="halAuthorId">214217</idno><affiliation ref="#struct-45572"></affiliation></author><author role="crp"><persName><forename type="first">Walter</forename><forename type="middle">A.</forename><surname>Rocca</surname></persName><email>rocca@mayo.edu</email><idno type="halAuthorId">214220</idno><affiliation ref="#struct-46397"></affiliation><affiliation ref="#struct-45572"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="pp">1688-92</biblScope><date type="datePub">2006-10</date></imprint></monogr><idno type="doi">10.1002/mds.21009</idno><idno type="pubmed">16773614</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><keywords scheme="author"><term xml:lang="es">chemical exposures</term><term xml:lang="es">pesticides</term><term xml:lang="es">Parkinson's disease</term><term xml:lang="es">case– control study</term><term xml:lang="es">sex differences</term></keywords><classCode scheme="mesh">Adult</classCode><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="mesh">Minnesota</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Parkinsonian Disorders</classCode><classCode scheme="mesh">Pesticides</classCode><classCode scheme="mesh">Risk Factors</classCode><classCode scheme="mesh">Smoking</classCode><classCode scheme="mesh">Aged, 80 and over</classCode><classCode scheme="mesh">Agriculture</classCode><classCode scheme="mesh">Case-Control Studies</classCode><classCode scheme="mesh">Causality</classCode><classCode scheme="mesh">Educational Status</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Health Surveys</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode><classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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