Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.
Identifieur interne : 000037 ( Hal/Checkpoint ); précédent : 000036; suivant : 000038Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.
Auteurs : David Devos [France] ; Kathy Dujardin ; Isabelle Poirot ; Caroline Moreau [France] ; Olivier Cottencin [France] ; Pierre Thomas [France] ; Alain Destée [France] ; Regis Bordet [France] ; Luc DefebvreSource :
- Movement Disorders [ 0885-3185 ] ; 2008-04-30.
Abstract
Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short-term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double-blind, randomized, placebo- controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage.
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DOI: 10.1002/mds.21966
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Droit et santé</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-301886" type="direct"><org type="institution" xml:id="struct-301886" status="VALID"><orgName>CRLCC Oscar Lambret</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name></author></analytic><idno type="DOI">10.1002/mds.21966</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2008-04-30</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short-term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double-blind, randomized, placebo- controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title><author role="aut"><persName><forename type="first">David</forename><surname>Devos</surname></persName><email></email><idno type="halauthor">365640</idno><affiliation ref="#struct-1296"></affiliation></author><author role="aut"><persName><forename type="first">Kathy</forename><surname>Dujardin</surname></persName><email></email><idno type="halauthor">365641</idno></author><author role="aut"><persName><forename type="first">Isabelle</forename><surname>Poirot</surname></persName><email></email><idno type="halauthor">365642</idno></author><author role="aut"><persName><forename type="first">Caroline</forename><forename type="middle">C.</forename><surname>Moreau</surname></persName><email></email><idno type="halauthor">113337</idno><affiliation ref="#struct-94723"></affiliation><affiliation ref="#struct-581"></affiliation><affiliation ref="#struct-11037"></affiliation></author><author role="aut"><persName><forename type="first">Olivier</forename><surname>Cottencin</surname></persName><email></email><idno type="halauthor">362835</idno><affiliation ref="#struct-11323"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Thomas</surname></persName><email></email><idno type="halauthor">165345</idno><affiliation ref="#struct-11323"></affiliation></author><author role="aut"><persName><forename type="first">Alain</forename><surname>Destée</surname></persName><email></email><idno type="halauthor">365643</idno><affiliation ref="#struct-58976"></affiliation></author><author role="aut"><persName><forename type="first">Regis</forename><surname>Bordet</surname></persName><email></email><idno type="halauthor">365644</idno><affiliation ref="#struct-2775"></affiliation><affiliation ref="#struct-2904"></affiliation><affiliation ref="#struct-199397"></affiliation></author><author role="aut"><persName><forename type="first">Luc</forename><surname>Defebvre</surname></persName><email></email><idno type="halauthor">365645</idno></author><editor role="depositor"><persName><forename>Anny</forename><surname>Wartel</surname></persName><email>a-wartel@chru-lille.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2008-11-05 15:53:33</date><date type="whenModified">2008-11-05 15:53:33</date><date type="whenReleased">2008-11-05 15:53:33</date><date type="whenProduced">2008-04-30</date></edition><respStmt><resp>contributor</resp><name key="132183"><persName><forename>Anny</forename><surname>Wartel</surname></persName><email>a-wartel@chru-lille.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-00336977</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00336977</idno><idno type="halBibtex">devos:hal-00336977</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2008, 23 (6), pp.850-7. <10.1002/mds.21966></idno><idno type="halRef">Movement Disorders, Wiley, 2008, 23 (6), pp.850-7. <10.1002/mds.21966></idno></publicationStmt><seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="UNIV-LILLE1">Université des Sciences et Technologie de Lille - Lille I</idno><idno type="stamp" n="UNIV-LILLE2">Université du Droit et de la Santé - Lille II</idno><idno type="stamp" n="UNIV-VALENCIENNES">Université de Valenciennes et du Hainaut-Cambresis</idno><idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno><idno type="stamp" n="RIIP_LILLE">Institut Pasteur de Lille</idno><idno type="stamp" n="FNCLCC" p="INSERM">UNICANCER</idno><idno type="stamp" n="LAMBRET" p="FNCLCC">Centre Oscar Lambret</idno><idno type="stamp" n="UNIV-AMU">HAL - Aix Marseille Université</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title><author role="aut"><persName><forename type="first">David</forename><surname>Devos</surname></persName><idno type="halAuthorId">365640</idno><affiliation ref="#struct-1296"></affiliation></author><author role="aut"><persName><forename type="first">Kathy</forename><surname>Dujardin</surname></persName><idno type="halAuthorId">365641</idno></author><author role="aut"><persName><forename type="first">Isabelle</forename><surname>Poirot</surname></persName><idno type="halAuthorId">365642</idno></author><author role="aut"><persName><forename type="first">Caroline</forename><forename type="middle">C.</forename><surname>Moreau</surname></persName><idno type="halAuthorId">113337</idno><affiliation ref="#struct-94723"></affiliation><affiliation ref="#struct-581"></affiliation><affiliation ref="#struct-11037"></affiliation></author><author role="aut"><persName><forename type="first">Olivier</forename><surname>Cottencin</surname></persName><idno type="halAuthorId">362835</idno><affiliation ref="#struct-11323"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Thomas</surname></persName><idno type="halAuthorId">165345</idno><affiliation ref="#struct-11323"></affiliation></author><author role="aut"><persName><forename type="first">Alain</forename><surname>Destée</surname></persName><idno type="halAuthorId">365643</idno><affiliation ref="#struct-58976"></affiliation></author><author role="aut"><persName><forename type="first">Regis</forename><surname>Bordet</surname></persName><idno type="halAuthorId">365644</idno><affiliation ref="#struct-2775"></affiliation><affiliation ref="#struct-2904"></affiliation><affiliation ref="#struct-199397"></affiliation></author><author role="aut"><persName><forename type="first">Luc</forename><surname>Defebvre</surname></persName><idno type="halAuthorId">365645</idno></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="pp">850-7</biblScope><date type="datePub">2008-04-30</date></imprint></monogr><idno type="doi">10.1002/mds.21966</idno><idno type="pubmed">18311826</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Antidepressive Agents</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Placebos</classCode><classCode scheme="mesh">Prevalence</classCode><classCode scheme="mesh">Psychiatric Status Rating Scales</classCode><classCode scheme="mesh">Citalopram</classCode><classCode scheme="mesh">Depression</classCode><classCode scheme="mesh">Desipramine</classCode><classCode scheme="mesh">Double-Blind Method</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short-term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double-blind, randomized, placebo- controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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